Therapeutic potential of positive AMPA receptor modulators in the treatment of neuropsychiatric disorders (Q36418013)

14 August 2017

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title

Therapeutic potential of positive AMPA receptor modulators in the treatment of neuropsychiatric disorders (English)

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14 August 2017

2

Daniel R Weinberger

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14 August 2017

Stefano Marenco

1

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14 August 2017

publication date

1 January 2006

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14 August 2017

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14 August 2017

volume

20

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14 August 2017

issue

3

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14 August 2017

page(s)

173-185

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Diazoxide blocks glutamate desensitization and prolongs excitatory postsynaptic currents in rat hippocampal neurons

14 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.2165%2F00023210-200620030-00001

Intra- and interstrain differences in models of "behavioral despair".

21 January 2018

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12 December 2020

LY392098, a novel AMPA receptor potentiator: electrophysiological studies in prefrontal cortical neurons

1 reference

12 December 2020

Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset

1 reference

12 December 2020

An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study

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12 December 2020

Influence of AMPA/kainate receptors on extracellular 5-hydroxytryptamine in rat midbrain raphe and forebrain

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12 December 2020

Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus

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12 December 2020

A drug that facilitates glutamatergic transmission reduces exploratory activity and improves performance in a learning-dependent task

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12 December 2020

Effects of 5'-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responses

1 reference

12 December 2020

Facilitation of glutamate receptors enhances memory

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12 December 2020

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

1 reference

12 December 2020

Aniracetam for treatment of patients with progressive supranuclear palsy

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12 December 2020

Modulation of AMPA/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus.

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12 December 2020

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam

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12 December 2020

Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model

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12 December 2020

A desensitization-selective potentiator of AMPA-type glutamate receptors

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12 December 2020

Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's disease

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12 December 2020

Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents.

1 reference

12 December 2020

Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: a case series

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12 December 2020

Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain

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12 December 2020

Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer's disease in Italy.

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12 December 2020

AMPA receptor potentiators as novel antidepressants

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12 December 2020

AMPA receptor modulators as cognitive enhancers

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12 December 2020

Activation of non-NMDA receptors stimulates acetylcholine and GABA release from dorsal hippocampus: a microdialysis study in the rat.

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12 December 2020

Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus

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12 December 2020

Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography.

1 reference

12 December 2020

Enhancement by an ampakine of memory encoding in humans.

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12 December 2020

Effects of the novel compound aniracetam (Ro 13-5057) upon impaired learning and memory in rodents

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12 December 2020

Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

1 reference

12 December 2020

Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear

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12 December 2020

Association between the BDNF 196 A/G polymorphism and sporadic Alzheimer's disease.

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12 December 2020

AMPA receptor facilitation accelerates fear learning without altering the level of conditioned fear acquired.

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12 December 2020

Chronic elevation of brain-derived neurotrophic factor by ampakines

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12 December 2020

AMPA receptor desensitization modulates synaptic responses induced by repetitive afferent stimulation in hippocampal slices

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12 December 2020

Facilitative effects of the ampakine CX516 on short-term memory in rats: correlations with hippocampal neuronal activity.

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12 December 2020

The effects of aniracetam (Ro 13-5057) on the enhancement and protection of memory.

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12 December 2020

Ampakines reduce methamphetamine-driven rotation and activate neocortex in a regionally selective fashion

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12 December 2020

4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propion

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12 December 2020

Long-term potentiation and cognitive drug discovery

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12 December 2020

Neurotrophic factors in Alzheimer's and Parkinson's disease brain

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12 December 2020

Effects of an AMPA receptor modulator on methamphetamine-induced hyperactivity in rats

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12 December 2020

Current perspectives on the development of non-biogenic amine-based antidepressants

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12 December 2020

A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E epsilon4 allele

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12 December 2020

7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys

1 reference

12 December 2020

Facilitation of olfactory learning by a modulator of AMPA receptors

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12 December 2020

Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors

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12 December 2020

Effects of S 18986-1, a novel cognitive enhancer, on memory performances in an object recognition task in rats

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12 December 2020

Facilitative effects of the ampakine CX516 on short-term memory in rats: enhancement of delayed-nonmatch-to-sample performance.

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12 December 2020

Enhancement of antidepressant potency by a potentiator of AMPA receptors

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12 December 2020

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

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12 December 2020

Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data

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12 December 2020

AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate.

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12 December 2020

Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action

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12 December 2020

Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.

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12 December 2020

LY503430: pharmacology, pharmacokinetics, and effects in rodent models of Parkinson's disease.

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12 December 2020

Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators

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12 December 2020

Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator

1 reference

12 December 2020

Effects of aniracetam on delayed matching-to-sample performance of monkeys and pigeons.

1 reference

12 December 2020

A profile of the behavioral changes produced by facilitation of AMPA-type glutamate receptors

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12 December 2020

Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants

1 reference

12 December 2020

Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance.

1 reference

12 December 2020

Antidepressant-like actions of an AMPA receptor potentiator (LY392098).

1 reference

12 December 2020

5'-alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity

1 reference

12 December 2020

7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization.

1 reference

12 December 2020

Examining the neural targets of the AMPA receptor potentiator LY404187 in the rat brain using pharmacological magnetic resonance imaging

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12 December 2020

Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease

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12 December 2020

Effects of a memory-enhancing drug on DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor currents and synaptic transmission in hippocampus

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12 December 2020

Centrally active modulators of glutamate receptors facilitate the induction of long-term potentiation in vivo

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12 December 2020

Synergistic interactions between ampakines and antipsychotic drugs

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12 December 2020

Enhanced glutamatergic neurotransmission facilitates classical conditioning in the freely moving rat.

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12 December 2020

LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease.

1 reference

12 December 2020

Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans.

1 reference

12 December 2020

(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices

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12 December 2020

LY404187: a novel positive allosteric modulator of AMPA receptors

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12 December 2020

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

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12 December 2020

The mechanism of action of aniracetam at synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors: indirect and direct effects on desensitization

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12 December 2020

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors modulate dopamine release in rat hippocampus and striatum

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12 December 2020

Identification of a site in GluR1 and GluR2 that is important for modulation of deactivation and desensitization.

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12 December 2020

Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators have different impact on synaptic transmission in the thalamus and hippocampus.

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12 December 2020

The AMPA receptor potentiator LY404187 increases cerebral glucose utilization and c-fos expression in the rat.

1 reference

12 December 2020

Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates

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12 December 2020

A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease

1 reference

12 December 2020

Neurotrophic actions of the novel AMPA receptor potentiator, LY404187, in rodent models of Parkinson's disease.

1 reference

12 December 2020

Aniracetam improves radial maze performance in rats

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12 December 2020

Facilitation of glutamate receptors reverses an age-associated memory impairment in rats

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12 December 2020

A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia

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12 December 2020

Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro

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12 December 2020

Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency.

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12 December 2020

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors

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12 December 2020

Modulating excitatory synaptic neurotransmission: potential treatment for neurological disease?

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12 December 2020

Factors regulating the magnitude of long-term potentiation induced by theta pattern stimulation

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12 December 2020

Novel therapeutic approaches beyond the serotonin receptor

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12 December 2020

10.2165/00023210-200620030-00001

Identifiers

DOI

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Dimensions Publication ID

14 August 2017

1050189121

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