Development of novel therapeutic strategies that target HIF-1. (Q36425968)

14 August 2017

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title

Development of novel therapeutic strategies that target HIF-1. (English)

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14 August 2017

1

Gregg L Semenza

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14 August 2017

language of work or name

English

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publication date

1 April 2006

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Expert Opinion on Therapeutic Targets

14 August 2017

published in

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14 August 2017

volume

10

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14 August 2017

issue

2

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14 August 2017

page(s)

267-280

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Hypoxia inducible factor-1: a novel target for cancer therapy

14 August 2017

cites work

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Targeting HIF-1 for cancer therapy

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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Purification and characterization of hypoxia-inducible factor 1

21 January 2018

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

21 January 2018

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Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

21 January 2018

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Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

21 January 2018

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Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

21 January 2018

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Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

21 January 2018

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

21 January 2018

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Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.267

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.267

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

A conserved family of prolyl-4-hydroxylases that modify HIF

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.267

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Functional analysis of hypoxia-inducible factor-1 alpha-mediated transactivation. Identification of amino acid residues critical for transcriptional activation and/or interaction with CREB-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Role of CBP in regulating HIF-1-mediated activation of transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Tumor hypoxia and malignant progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Role of VHL gene mutation in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Expression of hypoxia-inducible factor 1? in brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Mutation analysis of the HIF-1alpha oxygen-dependent degradation domain in invasive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

HIF-1-mediated activation of telomerase in cervical cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Genetic instabilities in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Why do cancers have high aerobic glycolysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

HIF-1alpha is essential for myeloid cell-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Regulation of the chemokine receptor CXCR4 by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Tumour biology: herceptin acts as an anti-angiogenic cocktail.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Phosphoinositide 3-kinases as drug targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Phosphoinositide 3-kinase: from viral oncoprotein to drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

AKT crystal structure and AKT-specific inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

An expanding role for mTOR in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

The biology and clinical relevance of the PTEN tumor suppressor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Cyclooxygenase regulates angiogenesis induced by colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

21 January 2018

Heat shock protein 90.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hsp90 as a therapeutic target in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1alpha (HIF-1alpha): structural requirement of bisphenol A for degradation of HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Redox regulation of cellular activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Schedule-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation, angiogenesis, and tumor growth by topotecan in U251-HRE glioblastoma xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

GL331 inhibits HIF-1alpha expression in a lung cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

DNA methylation and gene silencing in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Natural products as sources of new drugs over the period 1981-2002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Maximizing clinical benefit with trastuzumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Cancer genes and the pathways they control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hypoxia-inducible factor 1alpha/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Evaluation of hypoxia-inducible factor 1alpha overexpression as a predictor of tumour recurrence and progression in superficial urothelial bladder carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Significant correlation of hypoxia-inducible factor-1alpha with treatment outcome in cervical cancer treated with radical radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Prostaglandin E2 induces hypoxia-inducible factor-1alpha stabilization and nuclear localization in a human prostate cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

ERK activation upon hypoxia: involvement in HIF-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Rac1 activity is required for the activation of hypoxia-inducible factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Endostatin's antiangiogenic signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF-1alpha protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Laurenditerpenol, a new diterpene from the tropical marine alga Laurenciaintricata that potently inhibits HIF-1 mediated hypoxic signaling in breast tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Saururus cernuus lignans--potent small molecule inhibitors of hypoxia-inducible factor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.267

Glycobiology and cancer: meeting summary and future diections

21 January 2018

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/14728222.10.2.267

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/14728222.10.2.267

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/14728222.10.2.267

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/14728222.10.2.267

Induction of HIF-1alpha in response to hypoxia is instantaneous

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/14728222.10.2.267

Induction of hypoxia-inducible factor-1alpha by transcriptional and translational mechanisms

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/14728222.10.2.267

Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1517/14728222.10.2.267

Identifiers

DOI

10.1517/14728222.10.2.267

1 reference

14 August 2017

1 reference