Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning (Q36496591)

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English	Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning	scientific article

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14 August 2017

Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning (English)

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14 August 2017

Alexander van Oudenaarden

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Alexander van Oudenaarden

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15 November 2018

Timothy L. Bailey

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15 November 2018

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Andrew Paul McMahon

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Andrew P McMahon

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14 August 2017

Tarjei S Mikkelsen

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Tarjei Mikkelsen

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14 August 2017

Bradley Bernstein

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Bradley E Bernstein

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14 August 2017

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Martha L Bulyk

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14 August 2017

author name string

Kevin A Peterson

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14 August 2017

Yuichi Nishi

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14 August 2017

Wenxiu Ma

3

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14 August 2017

Anastasia Vedenko

4

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14 August 2017

Leila Shokri

5

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14 August 2017

Xiaoxiao Zhang

6

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14 August 2017

Matthew McFarlane

7

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14 August 2017

José-Manuel Baizabal

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14 August 2017

Jan Philipp Junker

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14 August 2017

Wing H Wong

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14 August 2017

publication date

1 December 2012

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14 August 2017

Genes & Development

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14 August 2017

26

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14 August 2017

24

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14 August 2017

2802-2816

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14 August 2017

An integrated encyclopedia of DNA elements in the human genome

1 reference

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30 September 2017

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube

1 reference

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30 September 2017

Sequentially acting Sox transcription factors in neural lineage development

1 reference

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30 September 2017

Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Pluripotency factors in embryonic stem cells regulate differentiation into germ layers

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30 September 2017

The cis-regulatory logic of Hedgehog gradient responses: key roles for gli binding affinity, competition, and cooperativity

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30 September 2017

The analysis of ChIP-Seq data

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30 September 2017

A unique chromatin signature uncovers early developmental enhancers in humans

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30 September 2017

Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog

1 reference

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30 September 2017

Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube

1 reference

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30 September 2017

Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity.

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30 September 2017

Universal protein-binding microarrays for the comprehensive characterization of the DNA-binding specificities of transcription factors

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30 September 2017

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

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30 September 2017

Imaging individual mRNA molecules using multiple singly labeled probes

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30 September 2017

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

1 reference

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30 September 2017

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

1 reference

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30 September 2017

Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Gas1 extends the range of Hedgehog action by facilitating its signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity

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30 September 2017

Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing

1 reference

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30 September 2017

Quantitative analysis of binding motifs mediating diverse spatial readouts of the Dorsal gradient in the Drosophila embryo

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

The floor plate: multiple cells, multiple signals

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

SOX genes and neural progenitor identity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Vertebrate neurogenesis is counteracted by Sox1-3 activity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

Identification of Cis-regulatory Elements in the Mouse Pax9/Nkx2-9 Genomic Region: Implication for Evolutionary Conserved Synteny

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30 September 2017

SOX2 functions to maintain neural progenitor identity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

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30 September 2017

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3533082

30 September 2017

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord

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30 September 2017

Small molecule modulation of Smoothened activity

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30 September 2017

Directed differentiation of embryonic stem cells into motor neurons

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30 September 2017

Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4.

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30 September 2017

The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides

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Neuronal specification in the spinal cord: inductive signals and transcriptional codes

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30 September 2017

A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

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30 September 2017

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

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30 September 2017

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

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30 September 2017

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice

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30 September 2017

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

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30 September 2017

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

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30 September 2017

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30 September 2017

Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants.

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30 September 2017

Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

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30 September 2017

The GLI gene encodes a nuclear protein which binds specific sequences in the human genome

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30 September 2017

Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS.

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28 June 2018

Mechanistic differences in the transcriptional interpretation of local and long-range Shh morphogen signaling.

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21 September 2018

An embryonic stem cell-based system for rapid analysis of transcriptional enhancers

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21 September 2018

Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity.

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21 September 2018

Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2.

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21 September 2018

Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms.

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21 September 2018

Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

1 reference

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A Requirement for Retinoic Acid-Mediated Transcriptional Activation in Ventral Neural Patterning and Motor Neuron Specification

1 reference

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