IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor (Q36617062)

15 August 2017

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title

IL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor (English)

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granulocyte-macrophage colony-stimulating factor signaling pathway

15 August 2017

main subject

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Gene Ontology release 2020-05-02

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James M Murphy

1

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author name string

Ian G Young

series ordinal

2

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15 August 2017

publication date

1 January 2006

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15 August 2017

published in

Vitamins and Hormones

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15 August 2017

volume

74

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15 August 2017

page(s)

1-30

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Three-dimensional structure of a genetically engineered variant of porcine growth hormone

15 August 2017

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7 January 2021

Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function.

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Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

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7 January 2021

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7 January 2021

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7 January 2021

Ligand-independent cell surface expression of the human soluble granulocyte-macrophage colony-stimulating factor receptor alpha subunit depends on co-expression of the membrane-associated receptor beta subunit

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7 January 2021

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7 January 2021

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7 January 2021

Saturation mutagenesis of human interleukin-3.

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7 January 2021

Functional replacement of cytokine receptor extracellular domains by leucine zippers

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7 January 2021

Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation

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7 January 2021

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region

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7 January 2021

Crucial role of the residue R280 at the F'-G' loop of the human granulocyte/macrophage colony-stimulating factor receptor alpha chain for ligand recognition

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7 January 2021

The structure of interleukin-2 complexed with its alpha receptor

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7 January 2021

Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation

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Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding

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7 January 2021

Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three recepto

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Reconstitution of the functional receptors for murine and human interleukin 5

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A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction

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7 January 2021

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

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7 January 2021

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist

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Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain

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7 January 2021

JAK2 is essential for activation of c-fos and c-myc promoters and cell proliferation through the human granulocyte-macrophage colony-stimulating factor receptor in BA/F3 cells.

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7 January 2021

The structure, organization, activation and plasticity of the erythropoietin receptor

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7 January 2021

Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF

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7 January 2021

A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all thr

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Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

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7 January 2021

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130

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7 January 2021

The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters

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7 January 2021

The hepatic interleukin-6 receptor Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand

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7 January 2021

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Identifiers

DOI

1 reference

15 August 2017

1 reference