A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. (Q36908567)

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31 January 2020

title

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations (English)

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31 January 2020

1

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31 January 2020

Sonia Martinez

6

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31 January 2020

Julen Oyarzabal

7

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31 January 2020

Joaquín Pastor

8

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Óscar Fernández-Capetillo

31 January 2020

10

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4

Rebeca Soria

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31 January 2020

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2

Matilde Murga

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31 January 2020

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Rafal Zur

3

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31 January 2020

Antonio Rodriguez

5

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31 January 2020

James R Bischoff

9

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publication date

8 May 2011

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Nature Structural & Molecular Biology

31 January 2020

published in

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volume

18

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issue

6

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31 January 2020

page(s)

721-727

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Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

31 January 2020

cites work

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29 September 2017

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Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations

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Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53.

29 September 2017

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Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases

29 September 2017

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Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response

29 September 2017

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A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

29 September 2017

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ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress

29 September 2017

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

29 September 2017

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ATR: an essential regulator of genome integrity

29 September 2017

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Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

29 September 2017

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An oncogene-induced DNA damage model for cancer development

29 September 2017

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ATR signaling can drive cells into senescence in the absence of DNA breaks

29 September 2017

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DNA damage signalling guards against activated oncogenes and tumour progression

29 September 2017

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

29 September 2017

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

29 September 2017

1 reference

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TopBP1 activates the ATR-ATRIP complex

29 September 2017

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ATM regulates ATR chromatin loading in response to DNA double-strand breaks

29 September 2017

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

29 September 2017

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Second-generation shRNA libraries covering the mouse and human genomes

29 September 2017

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Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

29 September 2017

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

29 September 2017

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

29 September 2017

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

29 September 2017

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

29 September 2017

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29 September 2017

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

29 September 2017

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Deregulation of cyclin E in human cells interferes with prereplication complex assembly

29 September 2017

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

29 September 2017

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A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

29 September 2017

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

29 September 2017

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

29 September 2017

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Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

29 September 2017

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

29 September 2017

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

29 September 2017

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

29 September 2017

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Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

29 September 2017

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

29 September 2017

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Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

29 September 2017

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Atm-deficient mice: a paradigm of ataxia telangiectasia

29 September 2017

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

29 September 2017

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The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

29 September 2017

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In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase

27 June 2018

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Deregulated cyclin E induces chromosome instability

27 June 2018

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Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells

27 June 2018

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Dual roles of ATM in the cellular response to radiation and in cell growth control.

4 September 2018

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNSMB.2076

21 January 2018

Identifiers

DOI

10.1038/NSMB.2076

1 reference

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31 January 2020

1 reference

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31 January 2020

PubMed publication ID

21552262

1 reference