The endless tale of non-homologous end-joining (Q37048174)

17 August 2017

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title

The endless tale of non-homologous end-joining (English)

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17 August 2017

Eric Weterings

1

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17 August 2017

David J Chen

series ordinal

2

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17 August 2017

publication date

1 January 2008

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17 August 2017

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17 August 2017

volume

18

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17 August 2017

issue

1

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17 August 2017

page(s)

114-124

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Genome maintenance mechanisms for preventing cancer

17 August 2017

cites work

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7 January 2021

Ageing or cancer: a review on the role of caretakers and gatekeepers

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7 January 2021

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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7 January 2021

DNA double-strand breaks: signaling, repair and the cancer connection

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7 January 2021

The two edges of the ATM sword: co-operation between repair and checkpoint functions

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7 January 2021

Chromosomal stability and the DNA double-stranded break connection

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7 January 2021

V(D)J recombination: RAG proteins, repair factors, and regulation

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7 January 2021

Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

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7 January 2021

Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

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7 January 2021

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

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7 January 2021

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

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7 January 2021

Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

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7 January 2021

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

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7 January 2021

A central region of Ku80 mediates interaction with Ku70 in vivo

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7 January 2021

The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit

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7 January 2021

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

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7 January 2021

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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7 January 2021

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

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7 January 2021

Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs

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7 January 2021

Electron microscopy reconstructions of DNA repair complexes

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7 January 2021

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

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7 January 2021

Synapsis of DNA ends by DNA-dependent protein kinase

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7 January 2021

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

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7 January 2021

The DNA-dependent protein kinase

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Repair of DNA double strand breaks by non-homologous end joining

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7 January 2021

Regulation of p53 in response to DNA damage

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DNA-dependent protein kinase-independent activation of p53 in response to DNA damage

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7 January 2021

DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

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7 January 2021

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

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7 January 2021

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

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7 January 2021

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

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7 January 2021

Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

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7 January 2021

The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain

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7 January 2021

DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

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7 January 2021

The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA

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7 January 2021

The role of DNA dependent protein kinase in synapsis of DNA ends.

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7 January 2021

Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

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7 January 2021

Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

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7 January 2021

trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining

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7 January 2021

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

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7 January 2021

Association of terminal deoxynucleotidyl transferase with Ku

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7 January 2021

Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair

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7 January 2021

Implication of DNA polymerase lambda in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts.

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7 January 2021

Functions and regulation of human artemis in double strand break repair

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7 January 2021

DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs

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7 January 2021

DNA-PK autophosphorylation facilitates Artemis endonuclease activity

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7 January 2021

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

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7 January 2021

Regulation and mechanisms of mammalian double-strand break repair

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7 January 2021

Processing of 3'-phosphoglycolate-terminated DNA double strand breaks by Artemis nuclease

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7 January 2021

Structure and function of mammalian DNA ligases

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7 January 2021

DNA ligases: structure, reaction mechanism, and function

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7 January 2021

Structure of an XRCC1 BRCT domain: a new protein-protein interaction module

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Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

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7 January 2021

DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains

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Crystal structure of an Xrcc4-DNA ligase IV complex

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7 January 2021

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining

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7 January 2021

Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive

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7 January 2021

Ku recruits the XRCC4-ligase IV complex to DNA ends

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7 January 2021

DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system

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7 January 2021

Defining interactions between DNA-PK and ligase IV/XRCC4.

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7 January 2021

Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK.

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7 January 2021

XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps

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7 January 2021

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

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7 January 2021

A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining

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7 January 2021

Processing of DNA for nonhomologous end-joining is controlled by kinase activity and XRCC4/ligase IV.

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7 January 2021

A biochemically defined system for mammalian nonhomologous DNA end joining

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7 January 2021

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

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7 January 2021

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

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7 January 2021

Nonhomologous end joining and V(D)J recombination require an additional factor

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7 January 2021

DNA double-strand break repair: a relentless hunt uncovers new prey.

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7 January 2021

Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence

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7 January 2021

Identifiers

DOI

10.1038/CR.2008.3

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17 August 2017

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