DPP-4 Inhibitors as Therapeutic Modulators of Immune Cell Function and Associated Cardiovascular and Renal Insulin Resistance in Obesity and Diabetes (Q37095161)

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scientific article published on 16 March 2013

Language	Label	Description	Also known as
English	DPP-4 Inhibitors as Therapeutic Modulators of Immune Cell Function and Associated Cardiovascular and Renal Insulin Resistance in Obesity and Diabetes	scientific article published on 16 March 2013

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

DPP-4 Inhibitors as Therapeutic Modulators of Immune Cell Function and Associated Cardiovascular and Renal Insulin Resistance in Obesity and Diabetes (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

0 references

circulatory system

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

insulin resistance

1 reference

based on heuristic

inferred from title

0 references

author name string

Annayya Aroor

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Susan McKarns

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Ravi Nistala

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Vincent Demarco

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Michael Gardner

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Mariana Garcia-Touza

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Adam Whaley-Connell

7

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

James R Sowers

8

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

publication date

16 March 2013

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Cardiorenal medicine

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

48-56

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Obesity-related alterations in cardiac lipid profile and nondipping blood pressure pattern during transition to diastolic dysfunction in male db/db mice

1 reference

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29 September 2017

Application of IL-2 therapy to target T regulatory cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Renal and cardiac effects of DPP4 inhibitors--from preclinical development to clinical research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Use of dipeptidyl peptidase-4 inhibitors for the treatment of patients with type 2 diabetes mellitus and chronic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Obesity and metabolic syndrome: an inflammatory condition

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo

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29 September 2017

Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome

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29 September 2017

The dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice

1 reference

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29 September 2017

Mechanisms of inflammatory responses in obese adipose tissue

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29 September 2017

Angiotensin receptor blockade increases pancreatic insulin secretion and decreases glucose intolerance during glucose supplementation in a model of metabolic syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Epidemiology of obesity, the metabolic syndrome, and chronic kidney disease

1 reference

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29 September 2017

The link between the renin-angiotensin-aldosterone system and renal injury in obesity and the metabolic syndrome

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

The Role of Overweight and Obesity in the Cardiorenal Syndrome

1 reference

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29 September 2017

Immunity as a link between obesity and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation

1 reference

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29 September 2017

Metabolic syndrome, insulin resistance and kidney function in non-diabetic individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Insulin resistance: the link between obesity and cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Inflammatory concepts of obesity

1 reference

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29 September 2017

Interleukin-10 released by CD4(+)CD25(+) natural regulatory T cells improves microvascular endothelial function through inhibition of NADPH oxidase activity in hypertensive mice

1 reference

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29 September 2017

New insights into insulin resistance in the diabetic heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Cardiovascular effects of DPP-4 inhibition: beyond GLP-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Obesity, metabolic syndrome and diabetic nephropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Transcriptional regulation of the Na⁺/H⁺ exchanger NHE3 by chronic exposure to angiotensin II in renal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Obesity and susceptibility to autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Epidemiology of the metabolic syndrome in the USA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

National Kidney Foundation consensus conference on cardiovascular and kidney diseases and diabetes risk: an integrated therapeutic approach to reduce events

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29 September 2017

Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Glucagon-like peptide-1 receptor signalling selectively regulates murine lymphocyte proliferation and maintenance of peripheral regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Macrophages, inflammation, and insulin resistance

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Prevalence and trends in obesity among US adults, 1999-2008

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

Relation between Childhood Obesity and Adult Cardiovascular Risk

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29 September 2017

Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?

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29 September 2017

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

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29 September 2017

S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2

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29 September 2017

High body mass index for age among US children and adolescents, 2003-2006

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29 September 2017

Insulin signalling in the heart

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29 September 2017

Insulin-resistant cardiomyopathy clinical evidence, mechanisms, and treatment options

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29 September 2017

Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.

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29 September 2017

Obesity cardiomyopathy: pathogenesis and pathophysiology

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29 September 2017

Cardiovascular actions of insulin

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29 September 2017

Prevalence of overweight and obesity in the United States, 1999-2004

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

29 September 2017

A causal role for uric acid in fructose-induced metabolic syndrome

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29 September 2017

Insulin treatment enhances AT1 receptor function in OK cells.

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29 September 2017

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29 September 2017

Obesity as a cardiovascular risk factor

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29 September 2017

Dysglycemia predicts cardiovascular and kidney disease in the Kidney Early Evaluation Program

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27 June 2018

DPP-4 inhibition on top of angiotensin receptor blockade offers a new therapeutic approach for diabetic nephropathy.

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3 September 2018

A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Combined treatment with a dipeptidyl peptidase-IV inhibitor (sitagliptin) and an angiotensin II type 1 receptor blocker (losartan) promotes islet regeneration via enhanced differentiation of pancreatic progenitor cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Effects of DPP-4 inhibition on cardiac metabolism and function in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Interleukin 10 inhibits interferon gamma- and tumor necrosis factor alpha-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Differential macrophage polarization in male and female BALB/c mice infected with coxsackievirus B3 defines susceptibility to viral myocarditis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Regulatory T cells ameliorate angiotensin II-induced cardiac damage

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Abdominal obesity and the spectrum of global cardiometabolic risks in US adults

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Dipeptidyl peptidase IV inhibition downregulates Na+ - H+ exchanger NHE3 in rat renal proximal tubule.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3743398

3 September 2018

Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance

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3 September 2018

Role of PI3-kinase in isoproterenol and IGF-1 induced ecNOS activity

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3 September 2018

Dipeptidyl Peptidase 4 Inhibitor Sitagliptin Protects Endothelial Function in Hypertension Through a Glucagon–Like Peptide 1–Dependent Mechanism

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4 December 2018

Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin

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12 December 2020

based on heuristic

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Th17 response promotes angiotensin II-induced atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23946724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23946724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase-4 modulates left ventricular dysfunction in chronic heart failure via angiogenesis-dependent and -independent actions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23946724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory T cells expressing PPAR-γ control inflammation in obesity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23946724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl peptidase IV inhibitor attenuates kidney injury in streptozotocin-induced diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23946724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic risk factors and renal disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23946724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T regulatory lymphocytes prevent aldosterone-induced vascular injury

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https://pubmed.ncbi.nlm.nih.gov/23946724

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1159/000348756

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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