Molecular pathogenesis of T-cell leukaemia and lymphoma (Q37141761)

18 August 2017

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title

Molecular pathogenesis of T-cell leukaemia and lymphoma (English)

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18 August 2017

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1

Iannis Aifantis

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18 August 2017

Elizabeth Raetz

2

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18 August 2017

Silvia Buonamici

series ordinal

3

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18 August 2017

publication date

1 May 2008

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Nature Reviews Immunology

18 August 2017

published in

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18 August 2017

volume

8

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18 August 2017

issue

5

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18 August 2017

page(s)

380-390

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Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study

18 August 2017

cites work

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Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast

31 March 2020

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The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.

31 March 2020

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Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

31 March 2020

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

31 March 2020

1 reference

31 March 2020

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Zoned out: functional mapping of stromal signaling microenvironments in the thymus

31 March 2020

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A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus

31 March 2020

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Thymic selection revisited: how essential is it?

31 March 2020

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To be or not to be a pro-T?

31 March 2020

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Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus

31 March 2020

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The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila

31 March 2020

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SnapShot: notch signaling pathway

31 March 2020

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The Notch transcription activation complex makes its move

31 March 2020

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TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

31 March 2020

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An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

31 March 2020

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Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells.

31 March 2020

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Notch1 expression in early lymphopoiesis influences B versus T lineage determination

31 March 2020

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Immunology. Keeping a tight leash on Notch.

31 March 2020

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Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

31 March 2020

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

31 March 2020

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The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.

31 March 2020

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On the brink of becoming a T cell.

31 March 2020

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

31 March 2020

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Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

31 March 2020

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Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

31 March 2020

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Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor.

31 March 2020

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Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.

31 March 2020

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Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway

31 March 2020

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Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells

31 March 2020

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Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

31 March 2020

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Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT

31 March 2020

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Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia

31 March 2020

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Requirement for cyclin D3 in lymphocyte development and T cell leukemias

31 March 2020

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The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

31 March 2020

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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

31 March 2020

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Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia

31 March 2020

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The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice.

31 March 2020

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Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.

31 March 2020

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An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice

31 March 2020

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Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice

31 March 2020

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Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice

31 March 2020

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Deregulated expression of TCL1 causes T cell leukemia in mice

31 March 2020

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p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis

31 March 2020

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p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice

31 March 2020

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Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL

31 March 2020

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Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.

31 March 2020

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The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation

31 March 2020

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Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins

31 March 2020

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Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells

31 March 2020

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The Tal1 oncoprotein inhibits E47-mediated transcription. Mechanism of inhibition

31 March 2020

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TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB.

31 March 2020

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Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia

31 March 2020

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lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif

31 March 2020

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lyl-1 and tal-1/scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny.

31 March 2020

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Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice

31 March 2020

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Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia

31 March 2020

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The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13

31 March 2020

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

31 March 2020

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The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins

31 March 2020

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The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)

31 March 2020

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The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells

31 March 2020

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Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1

31 March 2020

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The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells

31 March 2020

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HOX and non-HOX homeobox genes in leukemic hematopoiesis

31 March 2020

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Homeodomain-DNA recognition

31 March 2020

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HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).

31 March 2020

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A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias

31 March 2020

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Oncogenic transcription factors in the human acute leukemias

31 March 2020

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Hox11 controls the genesis of the spleen

31 March 2020

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Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3.

31 March 2020

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TLX1/HOX11 transcription factor inhibits differentiation and promotes a non-haemopoietic phenotype in murine bone marrow cells

31 March 2020

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Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

31 March 2020

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Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

31 March 2020

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Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis

31 March 2020

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Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

31 March 2020

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Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

31 March 2020

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Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

31 March 2020

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

31 March 2020

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Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

31 March 2020

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

31 March 2020

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Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

31 March 2020

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sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins

31 March 2020

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Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

31 March 2020

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

31 March 2020

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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

31 March 2020

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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

31 March 2020

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Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

31 March 2020

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Alu elements mediate MYB gene tandem duplication in human T-ALL

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI2304

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18 August 2017

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