Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins (Q37778022)

23 August 2017

1 reference

title

Permeabilization of the outer mitochondrial membrane by Bcl-2 proteins (English)

1 reference

23 August 2017

Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins (English)

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

17 June 2024

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687483

17 June 2024

1

Ana J. García-Sáez

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687483

17 June 2024

2

Gustavo Fuertes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687483

17 June 2024

4

Jesús Salgado

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20687483

17 June 2024

author name string

Jacob Suckale

3

1 reference

23 August 2017

language of work or name

English

0 references

publication date

1 January 2010

1 reference

full work available at URL

23 August 2017

http://link.springer.com/content/pdf/10.1007/978-1-4419-6327-7_8.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Advances in Experimental Medicine and Biology

17 June 2024

published in

1 reference

23 August 2017

volume

677

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23 August 2017

page(s)

91-105

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

23 August 2017

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

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Movement of Bax from the cytosol to mitochondria during apoptosis

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Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

17 June 2024

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Solution structure of BID, an intracellular amplifier of apoptotic signaling

17 June 2024

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Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

17 June 2024

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

17 June 2024

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Structure of Bax: coregulation of dimer formation and intracellular localization

17 June 2024

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Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

17 June 2024

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Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix

17 June 2024

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The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

17 June 2024

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The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

17 June 2024

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Solution structure of the antiapoptotic protein bcl-2

17 June 2024

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Structural biology of the Bcl-2 family of proteins

17 June 2024

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Anti-apoptotic Bcl-XL protein in complex with BH3 peptides of pro-apoptotic Bak, Bad, and Bim proteins: comparative molecular dynamics simulations.

17 June 2024

24

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Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

17 June 2024

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

17 June 2024

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Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim

17 June 2024

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BAX activation is initiated at a novel interaction site

17 June 2024

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Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

17 June 2024

29

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Why do regulators of apoptosis look like bacterial toxins?

17 June 2024

30

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https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

17 June 2024

31

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https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

17 June 2024

32

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex

17 June 2024

33

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Conformation of the Bax C-terminus regulates subcellular location and cell death

17 June 2024

34

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Membrane-insertion fragments of Bcl-xL, Bax, and Bid

17 June 2024

35

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https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

17 June 2024

36

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Involvement of the N-terminus of Bax in its intracellular localization and function.

17 June 2024

37

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Targeting of Bcl-2 to the mitochondrial outer membrane by a COOH-terminal signal anchor sequence.

17 June 2024

38

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Role of the C-terminal domain of Bax and Bcl-xL in their localization and function in yeast cells

17 June 2024

39

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The interaction of the Bax C-terminal domain with negatively charged lipids modifies the secondary structure and changes its way of insertion into membranes

17 June 2024

40

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Conformation of the C-terminal domain of the pro-apoptotic protein Bax and mutants and its interaction with membranes

17 June 2024

41

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Interaction of the C-terminal domain of Bcl-2 family proteins with model membranes.

17 June 2024

42

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How does the Bax-alpha1 targeting sequence interact with mitochondrial membranes? The role of cardiolipin

17 June 2024

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Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores.

17 June 2024

44

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Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins

17 June 2024

45

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

17 June 2024

46

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

17 June 2024

47

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

BID-dependent and BID-independent pathways for BAX insertion into mitochondria

17 June 2024

48

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

17 June 2024

50

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

17 June 2024

51

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2

17 June 2024

52

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

17 June 2024

53

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bcl-XL inhibits membrane permeabilization by competing with Bax.

17 June 2024

54

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

17 June 2024

55

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bax, along with lipid conspirators, allows cytochrome c to escape mitochondria

17 June 2024

56

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

17 June 2024

57

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

17 June 2024

58

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.

17 June 2024

59

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

17 June 2024

60

1 reference

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Analysis of endogenous Bax complexes during apoptosis using blue native PAGE: implications for Bax activation and oligomerization

17 June 2024

61

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

17 June 2024

62

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https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Contributions to Bax insertion and oligomerization of lipids of the mitochondrial outer membrane

17 June 2024

63

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https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes

17 June 2024

64

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Cholesterol effects on BAX pore activation

17 June 2024

65

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https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins

17 June 2024

66

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bcl-2 changes conformation to inhibit Bax oligomerization

17 June 2024

67

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria

17 June 2024

68

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Acid destabilization of the solution conformation of Bcl-xL does not drive its pH-dependent insertion into membranes

17 June 2024

69

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Evidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanism

17 June 2024

70

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NMR studies of the anti-apoptotic protein Bcl-xL in micelles

17 June 2024

71

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

17 June 2024

72

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

BCL-XL dimerization by three-dimensional domain swapping.

17 June 2024

73

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6327-7_8

Heat-Induced Dimerization of BCL-xLthrough α-Helix Swapping†

17 June 2024

74

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Bcl-xL forms two distinct homodimers at non-ionic detergents: implications in the dimerization of Bcl-2 family proteins

17 June 2024

75

1 reference

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Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax

17 June 2024

76

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Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis

17 June 2024

77

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Proapoptotic Bid binds to monolysocardiolipin, a new molecular connection between mitochondrial membranes and cell death

17 June 2024

78

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tBid interaction with cardiolipin primarily orchestrates mitochondrial dysfunctions and subsequently activates Bax and Bak.

17 June 2024

79

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Role of cardiolipin on tBid and tBid/Bax synergistic effects on yeast mitochondria

17 June 2024

80

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Cardiolipin provides specificity for targeting of tBid to mitochondria

17 June 2024

81

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Conformation of membrane-associated proapoptotic tBid

17 June 2024

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Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway

17 June 2024

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Bcl-2 family proteins as ion-channels

17 June 2024

84

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Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

17 June 2024

85

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Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

17 June 2024

86

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Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature.

17 June 2024

87

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Transbilayer lipid diffusion promoted by Bax: implications for apoptosis.

17 June 2024

88

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Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores

17 June 2024

89

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Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

17 June 2024

90

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Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation

17 June 2024

91

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Bax directly induces release of cytochrome c from isolated mitochondria

17 June 2024

92

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Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells

17 June 2024

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Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6

17 June 2024

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The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL.

17 June 2024

95

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Cytoprotection by Bcl-2 requires the pore-forming alpha5 and alpha6 helices

17 June 2024

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The putative pore-forming domain of Bax regulates mitochondrial localization and interaction with Bcl-X(L).

17 June 2024

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Direct evidence for membrane pore formation by the apoptotic protein Bax

17 June 2024

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Effect of lipids with different spontaneous curvature on the channel activity of colicin E1: evidence in favor of a toroidal pore

17 June 2024

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Lipid dependence of the channel properties of a colicin E1-lipid toroidal pore

17 June 2024

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Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptides

17 June 2024

101

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Free energies of molecular bound states in lipid bilayers: lethal concentrations of antimicrobial peptides

17 June 2024

102

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Pore formation by a Bax-derived peptide: effect on the line tension of the membrane probed by AFM.

17 June 2024

103

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Bcl-x(L) forms an ion channel in synthetic lipid membranes.

17 June 2024

104

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The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner.

17 June 2024

105

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tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation

17 June 2024

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Sheng wu yi xue gong cheng xue za zhi

17 June 2024

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Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes

17 June 2024

108

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Conversion of Bcl-2 to a Bax-like death effector by caspases

17 June 2024

109

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Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminals

17 June 2024

110

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Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

17 June 2024

111

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

17 June 2024

113

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The apoptotic protein tBid promotes leakage by altering membrane curvature

17 June 2024

114

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The Destabilization of Lipid Membranes Induced by the C-terminal Fragment of Caspase 8-cleaved Bid Is Inhibited by the N-terminal Fragment

17 June 2024

115

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Ion channel activity of the BH3 only Bcl-2 family member, BID.

17 June 2024

116

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tBid forms a pore in the liposome membrane

17 June 2024

117

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The apoptotic protein tBid promotes leakage by altering membrane curvature

17 June 2024

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Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity.

17 June 2024

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17 June 2024

The roles of Bid

120

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Regulation of Bcl-xL: a little bit of this and a little bit of STAT.

17 June 2024

121

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Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

17 June 2024

122

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JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells

17 June 2024

123

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Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis.

17 June 2024

124

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

17 June 2024

125

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Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

17 June 2024

126

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Instant decisions: transcription-independent control of death-receptor-mediated apoptosis

17 June 2024

127

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

17 June 2024

128

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PUMA, a novel proapoptotic gene, is induced by p53

17 June 2024

129

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

17 June 2024

130

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

17 June 2024

131

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

17 June 2024

132

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Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

17 June 2024

133

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

17 June 2024

134

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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

17 June 2024

135

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Regulated targeting of BAX to mitochondria.

17 June 2024

136

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Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

17 June 2024

137

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Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release

17 June 2024

138

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

17 June 2024

139

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

17 June 2024

140

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Dynamics and structure of the Bax-Bak complex responsible for releasing mitochondrial proteins during apoptosis

17 June 2024

141

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

17 June 2024

144

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Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

17 June 2024

145

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Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice

17 June 2024

146

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

17 June 2024

147

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

17 June 2024

148

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Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

17 June 2024

149

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Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

17 June 2024

150

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Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

17 June 2024

151

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

17 June 2024

152

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

17 June 2024

153

1 reference

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BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes

17 June 2024

154

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Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

17 June 2024

155

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17 June 2024

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