Intrinsically disordered proteins: from sequence and conformational properties toward drug discovery (Q38002804)

26 August 2017

title

Intrinsically disordered proteins: from sequence and conformational properties toward drug discovery (English)

1 reference

26 August 2017

1 reference

3

Markus Zweckstetter

1 reference

26 August 2017

Nasrollah Rezaei-Ghaleh

series ordinal

1

object named as

Nasrollah Rezaei-Ghaleh

1 reference

26 August 2017

2

Martin Blackledge

1 reference

26 August 2017

publication date

13 April 2012

1 reference

26 August 2017

1 reference

26 August 2017

volume

13

1 reference

26 August 2017

issue

7

1 reference

26 August 2017

page(s)

930-950

1 reference

Proteins with weakly funneled energy landscapes challenge the classical structure-function paradigm

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Polymer principles and protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

1H nuclear-magnetic-resonance studies of the molecular conformation of monomeric glucagon in aqueous solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Intrinsically unstructured proteins and their functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

DisProt: the Database of Disordered Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Comparing and combining predictors of mostly disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The interplay between structure and function in intrinsically unstructured proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Linking folding and binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Coupling of folding and binding for unstructured proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Flexible nets. The roles of intrinsic disorder in protein interaction networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The intermembrane space domain of Tim23 is intrinsically disordered with a distinct binding region for presequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Intrinsically disordered protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Natively unfolded proteins: a point where biology waits for physics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Intrinsic disorder and functional proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Protein flexibility and intrinsic disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Sequence complexity of disordered protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The Ka/Ks ratio: diagnosing the form of sequence evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Rapid sequence evolution of the mammalian sex-determining gene SRY.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Intrinsically unstructured proteins evolve by repeat expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Predicting intrinsic disorder from amino acid sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Length-dependent prediction of protein intrinsic disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Protein disorder prediction: implications for structural proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The DISOPRED server for the prediction of protein disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

GlobPlot: Exploring protein sequences for globularity and disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NORSp: Predictions of long regions without regular secondary structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Predicting intrinsic disorder in proteins: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Prediction of disordered regions in proteins based on the meta approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

PONDR-FIT: a meta-predictor of intrinsically disordered amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Archaic chaos: intrinsically disordered proteins in Archaea

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Natively unfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Preformed structural elements feature in partner recognition by intrinsically unstructured proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Analysis of molecular recognition features (MoRFs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Coupled folding and binding with alpha-helix-forming molecular recognition elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The interaction of eIF4E with 4E-BP1 is an induced fit to a completely disordered protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Characterization of molecular recognition features, MoRFs, and their binding partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Mining alpha-helix-forming molecular recognition features with cross species sequence alignments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Prediction of protein binding regions in disordered proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

ELM: the status of the 2010 eukaryotic linear motif resource

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Unstructural biology coming of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

SLiMFinder: a web server to find novel, significantly over-represented, short protein motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Intrinsically disordered proteins are potential drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Biophysical characterization of intrinsically disordered proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Low-resolution structure of a vesicle disrupting α-synuclein oligomer that accumulates during fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Small-angle scattering for structural biology--expanding the frontier while avoiding the pitfalls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural characterization of proteins and complexes using small-angle X-ray solution scattering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural analysis of intrinsically disordered proteins by small-angle X-ray scattering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural characterization of flexible proteins using small-angle X-ray scattering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Multidomain assembled states of Hck tyrosine kinase in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

SAXS ensemble refinement of ESCRT-III CHMP3 conformational transitions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient α-helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Proline-rich salivary proteins have extended conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Tail-Mediated Collapse of HMGB1 Is Dynamic and Occurs via Differential Binding of the Acidic Tail to the A and B Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Improved structural characterizations of the drkN SH3 domain unfolded state suggest a compact ensemble with native-like and non-native structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structure and disorder in an unfolded state under nondenaturing conditions from ensemble models consistent with a large number of experimental restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Unfolded proteins and protein folding studied by NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural polymorphism of 441-residue tau at single residue resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Sequence-specific resonance assignment of soluble nonglobular proteins by 7D APSY-NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Automatic assignment of the intrinsically disordered protein Tau with 441-residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift data

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Atomic-level characterization of disordered protein ensembles

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NMR structural and dynamic characterization of the acid-unfolded state of apomyoglobin provides insights into the early events in protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Characteristics of human lysozyme and its disease-related mutants in their unfolded states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Analysis of main chain torsion angles in proteins: prediction of NMR coupling constants for native and random coil conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Sequence-specific random coil chemical shifts of intrinsically disordered proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Random coil chemical shift for intrinsically disordered proteins: effects of temperature and pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Sequence-dependent correction of random coil NMR chemical shifts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Linear analysis of carbon-13 chemical shift differences and its application to the detection and correction of errors in referencing and spin system identifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Interpreting protein chemical shift data

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Aromatic and methyl NOEs highlight hydrophobic clustering in the unfolded state of an SH3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Calculation of residual dipolar couplings from disordered state ensembles using local alignment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Short-range, long-range and transition state interactions in the denatured state of ACBP from residual dipolar couplings

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural characterization of unfolded states of apomyoglobin using residual dipolar couplings

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Statistical coil model of the unfolded state: resolving the reconciliation problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

A structural model for unfolded proteins from residual dipolar couplings and small-angle x-ray scattering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Paramagnetic relaxation enhancements in unfolded proteins: theory and application to drkN SH3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Transient structure formation in unfolded acyl-coenzyme A-binding protein observed by site-directed spin labelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural interpretation of paramagnetic relaxation enhancement-derived distances for disordered protein states

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NMR characterization of long-range order in intrinsically disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural and dynamical properties of a denatured protein. Heteronuclear 3D NMR experiments and theoretical simulations of lysozyme in 8 M urea

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Long-range interactions within a nonnative protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Effect of zinc binding on β-amyloid structure and dynamics: implications for Aβ aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

A study of protein side-chain dynamics from new 2H auto-correlation and 13C cross-correlation NMR experiments: application to the N-terminal SH3 domain from drk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

A Transient and Low-Populated Protein-Folding Intermediate at Atomic Resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Towards a robust description of intrinsic protein disorder using nuclear magnetic resonance spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Constructing ensembles for intrinsically disordered proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Rapid and accurate calculation of protein 1H, 13C and 15N chemical shifts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Automated prediction of 15N, 13Calpha, 13Cbeta and 13C' chemical shifts in proteins using a density functional database

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Protein backbone chemical shifts predicted from searching a database for torsion angle and sequence homology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Fast and accurate predictions of protein NMR chemical shifts from interatomic distances.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Refinement of ensembles describing unstructured proteins using NMR residual dipolar couplings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Ensemble calculations of unstructured proteins constrained by RDC and PRE data: a case study of urea-denatured ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Determination of the free energy landscape of alpha-synuclein using spin label nuclear magnetic resonance measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Tertiary contact formation in alpha-synuclein probed by electron transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Replica-exchange molecular dynamics method for protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

An exact formulation of hyperdynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The effect of a DeltaK280 mutation on the unfolded state of a microtubule-binding repeat in Tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Quantitative description of backbone conformational sampling of unfolded proteins at amino acid resolution from NMR residual dipolar couplings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Quantitative conformational analysis of partially folded proteins from residual dipolar couplings: application to the molecular recognition element of Sendai virus nucleoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Defining conformational ensembles of intrinsically disordered and partially folded proteins directly from chemical shifts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Protein folding at single-molecule resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Multiple conformations of full-length p53 detected with single-molecule fluorescence resonance energy transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Random-coil behavior and the dimensions of chemically unfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Interaction of urea with amino acids: implications for urea-induced protein denaturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

A self-consistent description of the conformational behavior of chemically denatured proteins from NMR and small angle scattering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NMR studies of unfolded states of an SH3 domain in aqueous solution and denaturing conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Urea promotes polyproline II helix formation: implications for protein denatured states

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Polyproline II conformation is one of many local conformational states and is not an overall conformation of unfolded peptides and proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Equilibrium collapse and the kinetic 'foldability' of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NOE data demonstrating a compact unfolded state for an SH3 domain under non-denaturing conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Proline-directed random-coil chemical shift values as a tool for the NMR assignment of the tau phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NMR analysis of a Tau phosphorylation pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NMR spectroscopy brings invisible protein states into focus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Exact distances and internal dynamics of perdeuterated ubiquitin from NOE buildups.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Speeding molecular recognition by using the folding funnel: the fly-casting mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Kinetics of folding and binding of an intrinsically disordered protein: the inhibitor of yeast aspartic proteinase YPrA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Fly-casting in protein-DNA binding: frustration between protein folding and electrostatics facilitates target recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Intrinsically disordered proteins: regulation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Proteasomal degradation of tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Enhanced alpha-synuclein expression in human neurodegenerative diseases: pathogenetic and therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The nanny model for IDPs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Intrinsic disorder in cell-signaling and cancer-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The N-terminal domain of p53 is natively unfolded.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Live or let die: the cell's response to p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NMR studies in aqueous solution fail to identify significant conformational differences between the monomeric forms of two Alzheimer peptides with widely different plaque-competence, A beta(1-40)(ox) and A beta(1-42)(ox).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Folding and misfolding of alpha-synuclein on membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Protein interaction networks from yeast to human

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Drugs for ‘protein clouds’: targeting intrinsically disordered transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Multiple independent binding sites for small-molecule inhibitors on the oncoprotein c-Myc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Substrate-targeting gamma-secretase modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Monomeric α-synuclein binds Congo Red micelles in a disordered manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Single-Step Determination of Protein Substructures Using Dipolar Couplings: Aid to Structural Genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Direct Observation of Dipolar Couplings and Hydrogen Bonds across a β-Hairpin in 8 M Urea

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Mapping the Conformational Landscape of Urea-Denatured Ubiquitin Using Residual Dipolar Couplings

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

13C-detected protonless NMR spectroscopy of proteins in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

The effects of guanidine hydrochloride on the 'random coil' conformations and NMR chemical shifts of the peptide series GGXGG

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Theoretical framework for NMR residual dipolar couplings in unfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

NMR determination of residual structure in a urea-denatured protein, the 434-repressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Characterization of the residual structure in the unfolded state of the Δ131Δ fragment of staphylococcal nuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

Defining Long-Range Order and Local Disorder in Native α-Synuclein Using Residual Dipolar Couplings

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200093

21 January 2018

Identifiers

DOI

10.1002/CBIC.201200093

1 reference

26 August 2017

1 reference