Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. (Q38085689)

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scientific article published on 19 March 2013

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English	Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.	scientific article published on 19 March 2013

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24 February 2020

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies (English)

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Tiago Fleming Outeiro

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Donato A Di Monte

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Stefan Schildknecht

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Hanne R Gerding

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Christiaan Karreman

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Malte Drescher

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Hilal A Lashuel

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Journal of Neurochemistry

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24 February 2020

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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21 January 2018

Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family

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21 January 2018

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

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21 January 2018

On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation

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21 January 2018

Genetic analysis of families with Parkinson disease that carry the Ala53Thr mutation in the gene encoding alpha-synuclein

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21 January 2018

Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

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21 January 2018

Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein

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21 January 2018

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

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21 January 2018

Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons

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21 January 2018

Mechanistic aspects of Parkinson's disease: alpha-synuclein and the biomembrane

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21 January 2018

Dopamine quinones interact with alpha-synuclein to form unstructured adducts.

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21 January 2018

Pathoanatomy of Parkinson's disease

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21 January 2018

Staging of brain pathology related to sporadic Parkinson's disease

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21 January 2018

Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

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21 January 2018

α-Synuclein phosphorylation as a therapeutic target in Parkinson's disease

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21 January 2018

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme

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21 January 2018

Localization of nitric oxide synthase indicating a neural role for nitric oxide

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21 January 2018

Α-synuclein misfolding and Parkinson's disease

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21 January 2018

Modulation of alpha-synuclein expression in transgenic animals for modelling synucleinopathies--is the juice worth the squeeze?

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21 January 2018

Chemical strategies for controlling protein folding and elucidating the molecular mechanisms of amyloid formation and toxicity

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21 January 2018

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

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21 January 2018

Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase.

1 reference

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21 January 2018

Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

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21 January 2018

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

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21 January 2018

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

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21 January 2018

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

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21 January 2018

Chemical model systems for cellular nitros(yl)ation reactions

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21 January 2018

Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson's disease.

1 reference

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21 January 2018

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

1 reference

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21 January 2018

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

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21 January 2018

Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

1 reference

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21 January 2018

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

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21 January 2018

Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity

1 reference

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21 January 2018

The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?

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21 January 2018

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes

1 reference

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21 January 2018

Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease

1 reference

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21 January 2018

Conformational properties of alpha-synuclein in its free and lipid-associated states

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

1 reference

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21 January 2018

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

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21 January 2018

The oxidant stress hypothesis in Parkinson's disease: evidence supporting it

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21 January 2018

Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein

1 reference

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21 January 2018

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

1 reference

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21 January 2018

May the evaluation of nitrosative stress through selective increase of 3-nitrotyrosine proteins other than nitroalbumin and dominant tyrosine-125/136 nitrosylation of serum α-synuclein serve for diagnosis of sporadic Parkinson's disease?

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The aggregation and fibrillation of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

In vivo autoxidation of dopamine in guinea pig striatum increases with age.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Lipid rafts mediate the synaptic localization of alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Redox regulation: a new challenge for pharmacology

1 reference

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21 January 2018

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease

1 reference

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21 January 2018

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

1 reference

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21 January 2018

100 years of Lewy pathology

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21 January 2018

Carbonate radical ion is the only observable intermediate in the reaction of peroxynitrite with CO(2).

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Über die Katalyse des Hydroperoxydes

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Beyond α-synuclein transfer: pathology propagation in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.

1 reference

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21 January 2018

Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Role of individual methionines in the fibrillation of methionine-oxidized alpha-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

alpha-synuclein promotes mitochondrial deficit and oxidative stress

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The reaction of no with superoxide

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21 January 2018

Protein tyrosine nitration--an update

1 reference

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21 January 2018

The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1 reference

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21 January 2018

Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Binding of alpha-synuclein affects the lipid packing in bilayers of small vesicles

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The Haber-Weiss reaction and mechanisms of toxicity

1 reference

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21 January 2018

Controlling the mass action of alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

A combinatorial code for the interaction of alpha-synuclein with membranes

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Neurodegenerative disease: amyloid pores from pathogenic mutations

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The many faces of α-synuclein: from structure and toxicity to therapeutic target

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Proteasomal inhibition by alpha-synuclein filaments and oligomers.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

A novel molecular mechanism for nitrated {alpha}-synuclein-induced cell death

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Lysosomal degradation of alpha-synuclein in vivo.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Impact of N-terminal acetylation of α-synuclein on its random coil and lipid binding properties

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Cellular oligomerization of alpha-synuclein is determined by the interaction of oxidized catechols with a C-terminal sequence

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Pathologic modifications of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated squirrel monkeys

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Methionine sulfoxide reductases: ubiquitous enzymes involved in antioxidant defense, protein regulation, and prevention of aging-associated diseases

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Membrane binding and self-association of alpha-synucleins.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Antibodies against alpha-synuclein reduce oligomerization in living cells

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

An introduction to the free radical hypothesis in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Yeast cells provide insight into alpha-synuclein biology and pathobiology

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Mitochondrial association of alpha-synuclein causes oxidative stress

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Effect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Locally resolved membrane binding affinity of the N-terminus of α-synuclein.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Mitochondrial dynamics and neuronal fate in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Peroxynitrite as regulator of vascular prostanoid synthesis

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Neuroprotection by minocycline caused by direct and specific scavenging of peroxynitrite

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Autocatalytic nitration of prostaglandin endoperoxide synthase-2 by nitrite inhibits prostanoid formation in rat alveolar macrophages

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Control of Aβ release from human neurons by differentiation status and RET signaling

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Structure and dynamics of micelle-bound human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

α-Synuclein elevation in human neurodegenerative diseases: experimental, pathogenetic, and therapeutic implications.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Effects of nitration on the structure and aggregation of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The first N-terminal amino acids of alpha-synuclein are essential for alpha-helical structure formation in vitro and membrane binding in yeast

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The sour side of neurodegenerative disorders: the effects of protein glycation.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Environmental toxins in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Tyrosine modification by reactive nitrogen species: a closer look

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

In vivo demonstration that alpha-synuclein oligomers are toxic

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Cytosolic proteins regulate alpha-synuclein dissociation from presynaptic membranes

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Nitration inhibits fibrillation of human α‐synuclein in vitro by formation of soluble oligomers

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Role of alpha-synuclein in presynaptic dopamine recruitment.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Mitochondrial fission, fusion, and stress

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Methionine oxidation stabilizes non-toxic oligomers of alpha-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Lipid binding inhibits alpha-synuclein fibril formation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12226

21 January 2018

Identifiers

10.1111/JNC.12226

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23452040%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

release_5ubudrji3zaxjadsnggbyzhszy

1 reference

https://api.fatcat.wiki/v0/release/5ubudrji3zaxjadsnggbyzhszy

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23452040%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

ResearchGate publication ID

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