The immunobiology of prion diseases (Q38159911)

30 August 2017

title

The immunobiology of prion diseases (English)

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30 August 2017

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Mario Nuvolone

2

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Adriano Aguzzi

series ordinal

1

object named as

Adriano Aguzzi

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30 August 2017

Caihong Zhu

3

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30 August 2017

language of work or name

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5 November 2013

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Nature Reviews Immunology

30 August 2017

published in

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30 August 2017

volume

13

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30 August 2017

issue

12

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30 August 2017

page(s)

888-902

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Degenerative disease of the central nervous system in New Guinea; the endemic occurrence of kuru in the native population

30 August 2017

cites work

1 reference

A new variant of Creutzfeldt-Jakob disease in the UK.

31 March 2020

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Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion

31 March 2020

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Prion infectivity in the spleen of a PRNP heterozygous individual with subclinical variant Creutzfeldt-Jakob disease

31 March 2020

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Novel proteinaceous infectious particles cause scrapie

31 March 2020

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An analytical solution to the kinetics of breakable filament assembly

31 March 2020

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Normal host prion protein necessary for scrapie-induced neurotoxicity

31 March 2020

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Physiology of the prion protein

31 March 2020

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Microglia: scapegoat, saboteur, or something else?

31 March 2020

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Antiprion immunotherapy: to suppress or to stimulate?

31 March 2020

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Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

31 March 2020

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Axonal prion protein is required for peripheral myelin maintenance

31 March 2020

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Prion protein expression regulates embryonic stem cell pluripotency and differentiation

31 March 2020

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Requirement of cellular prion protein for intestinal barrier function and mislocalization in patients with inflammatory bowel disease

31 March 2020

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Cutting Edge: Brucella abortus Exploits a Cellular Prion Protein on Intestinal M Cells as an Invasive Receptor

31 March 2020

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SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells

31 March 2020

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The cellular prion protein modulates phagocytosis and inflammatory response

31 March 2020

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Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

31 March 2020

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Generating a prion with bacterially expressed recombinant prion protein

31 March 2020

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Pathogenesis of scrapie in mice after intragastric infection

31 March 2020

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Oral prion infection requires normal numbers of Peyer's patches but not of enteric lymphocytes

31 March 2020

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Bacterial colitis increases susceptibility to oral prion disease

31 March 2020

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Transepithelial prion transport by M cells

31 March 2020

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M cell-depletion blocks oral prion disease pathogenesis.

31 March 2020

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Prion uptake in the gut: identification of the first uptake and replication sites

31 March 2020

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In vitro interaction of scrapie agent and mouse peritoneal macrophages

31 March 2020

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Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis

31 March 2020

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Migrating intestinal dendritic cells transport PrP(Sc) from the gut.

31 March 2020

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In Vivo Depletion of CD11c+ Cells Impairs Scrapie Agent Neuroinvasion from the Intestine

31 March 2020

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Transmission of BSE by blood transfusion in sheep

31 March 2020

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Infectious prions in the saliva and blood of deer with chronic wasting disease

31 March 2020

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Surgical treatment and risk of sporadic Creutzfeldt-Jakob disease: a case-control study

31 March 2020

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Transmission of scrapie by oral route: effect of gingival scarification

31 March 2020

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Scrapie transmission following exposure through the skin is dependent on follicular dendritic cells in lymphoid tissues

31 March 2020

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Role of the draining lymph node in scrapie agent transmission from the skin

31 March 2020

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Aerosol transmission of chronic wasting disease in white-tailed deer.

31 March 2020

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Aerosols transmit prions to immunocompetent and immunodeficient mice

31 March 2020

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Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay

31 March 2020

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Rapid transepithelial transport of prions following inhalation

31 March 2020

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Further Observations on the Experimental Production of Scrapie in Goats and Sheep

31 March 2020

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Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus)

31 March 2020

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Prion immunoreactivity in appendix before clinical onset of variant Creutzfeldt-Jakob disease

31 March 2020

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Lack of effect of thymus and spleen on the incubation period of Creutzfeldt-Jakob disease in mice

31 March 2020

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Facilitated cross-species transmission of prions in extraneural tissue.

31 March 2020

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Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy

31 March 2020

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Pathogenesis of Scrapie in the Mouse: the Role of the Spleen

31 March 2020

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The role of the spleen in the neuroinvasion of scrapie in mice

31 March 2020

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Severely combined immunodeficient (SCID) mice resist infection with bovine spongiform encephalopathy

31 March 2020

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Pathogenesis of mouse scrapie: distribution of agent in the pulp and stroma of infected spleens

31 March 2020

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Ionising radiation has no influence on scrapie incubation period in mice

31 March 2020

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A crucial role for B cells in neuroinvasive scrapie.

31 March 2020

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Mice devoid of PrP are resistant to scrapie

31 March 2020

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PrP expression in B lymphocytes is not required for prion neuroinvasion

31 March 2020

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B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice

31 March 2020

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PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain

31 March 2020

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Efficient lymphoreticular prion propagation requires PrP(c) in stromal and hematopoietic cells.

31 March 2020

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Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells

31 March 2020

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Prion replication in the hematopoietic compartment is not required for neuroinvasion in scrapie mouse model.

31 March 2020

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Follicular dendritic cells emerge from ubiquitous perivascular precursors

31 March 2020

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Impaired prion replication in spleens of mice lacking functional follicular dendritic cells

31 March 2020

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Temporary inactivation of follicular dendritic cells delays neuroinvasion of scrapie

31 March 2020

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Temporary blockade of the tumor necrosis factor receptor signaling pathway impedes the spread of scrapie to the brain

31 March 2020

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Follicular dendritic cell dedifferentiation by treatment with an inhibitor of the lymphotoxin pathway dramatically reduces scrapie susceptibility

31 March 2020

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Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells

31 March 2020

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Complement facilitates early prion pathogenesis

31 March 2020

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Temporary depletion of complement component C3 or genetic deficiency of C1q significantly delays onset of scrapie.

31 March 2020

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Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis

31 March 2020

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Follicular dendritic cell-specific prion protein (PrP) expression alone is sufficient to sustain prion infection in the spleen

31 March 2020

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Chronic Lymphocytic Inflammation Specifies the Organ Tropism of Prions

31 March 2020

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Coincident scrapie infection and nephritis lead to urinary prion excretion

31 March 2020

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Abnormal prion protein in ectopic lymphoid tissue in a kidney of an asymptomatic white-tailed deer experimentally inoculated with the agent of chronic wasting disease

31 March 2020

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PrPSc in mammary glands of sheep affected by scrapie and mastitis

31 March 2020

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Prions in milk from ewes incubating natural scrapie

31 March 2020

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Evidence of effective scrapie transmission via colostrum and milk in sheep

31 March 2020

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Sheep with scrapie and mastitis transmit infectious prions through the milk

31 March 2020

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Lymphotoxin, but not TNF, is required for prion invasion of lymph nodes

31 March 2020

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Lymphotoxin-Dependent Prion Replication in Inflammatory Stromal Cells of Granulomas

31 March 2020

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Pathogenesis of mouse scrapie: dynamics of vacuolation in brain and spinal cord after intraperitoneal infection

31 March 2020

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Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie

31 March 2020

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Disease-associated PrP in the enteric nervous system of scrapie-affected Suffolk sheep

31 March 2020

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Sympathetic innervation of lymphoreticular organs is rate limiting for prion neuroinvasion

31 March 2020

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PrP(CWD) in the myenteric plexus, vagosympathetic trunk and endocrine glands of deer with chronic wasting disease

31 March 2020

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The sympathetic nervous system is involved in variant Creutzfeldt-Jakob disease

31 March 2020

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Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion

31 March 2020

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Cells release prions in association with exosomes

31 March 2020

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Prions hijack tunnelling nanotubes for intercellular spread

31 March 2020

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The most infectious prion protein particles.

31 March 2020

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Retrograde transport of transmissible mink encephalopathy within descending motor tracts

31 March 2020

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Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice

31 March 2020

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Protective role of interferon regulatory factor 3-mediated signaling against prion infection.

31 March 2020

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Prion pathogenesis in the absence of Toll-like receptor signalling

31 March 2020

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Murine scrapie infection causes an abnormal germinal centre reaction in the spleen

31 March 2020

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Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie

31 March 2020

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Germinal center B cells are dispensable in prion transport and neuroinvasion

31 March 2020

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Immunohistochemical study of microglia in the Creutzfeldt-Jakob diseased brain

31 March 2020

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Characterization of the microglial response in murine scrapie

31 March 2020

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Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures.

31 March 2020

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A versatile prion replication assay in organotypic brain slices

31 March 2020

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Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner

31 March 2020

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Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation.

31 March 2020

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Heightened intrathecal release of proinflammatory cytokines in Creutzfeldt-Jakob disease

31 March 2020

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Heightened expression of tumor necrosis factor alpha, interleukin 1 alpha, and glial fibrillary acidic protein in experimental Creutzfeldt-Jakob disease in mice

31 March 2020

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Absence of detectable IL-1beta production in murine prion disease: a model of chronic neurodegeneration

31 March 2020

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Interleukin 4 and interleukin 10 levels are elevated in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease

31 March 2020

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Role of interleukin-1 in prion disease-associated astrocyte activation

31 March 2020

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Genes contributing to prion pathogenesis

31 March 2020

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Sod1 deficiency reduces incubation time in mouse models of prion disease

31 March 2020

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Accelerated prion disease in the absence of interleukin-10.

31 March 2020

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MCP-1 and murine prion disease: separation of early behavioural dysfunction from overt clinical disease

31 March 2020

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Investigation of mcp1 as a quantitative trait gene for prion disease incubation time in mouse

31 March 2020

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Role of Erk1/2 activation in prion disease pathogenesis: absence of CCR1 leads to increased Erk1/2 activation and accelerated disease progression

31 March 2020

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Identification of upregulated genes in scrapie-infected brain tissue

31 March 2020

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Accelerated prion replication in, but prolonged survival times of, prion-infected CXCR3-/- mice

31 March 2020

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Microglia from Creutzfeldt-Jakob disease-infected brains are infectious and show specific mRNA activation profiles

31 March 2020

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Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

31 March 2020

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Abnormal activation of microglia accompanied with disrupted CX3CR1/CX3CL1 pathway in the brains of the hamsters infected with scrapie agent 263K.

31 March 2020

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Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice

31 March 2020

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Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein

31 March 2020

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Prion propagation in mice lacking central nervous system NF- B signalling

31 March 2020

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Repetitive immunization enhances the susceptibility of mice to peripherally administered prions

31 March 2020

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Genetic depletion of complement receptors CD21/35 prevents terminal prion disease in a mouse model of chronic wasting disease

31 March 2020

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Postexposure prophylaxis against prion disease with a stimulator of innate immunity

31 March 2020

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Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

31 March 2020

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Immunoaffinity purification and neutralization of scrapie prion infectivity

31 March 2020

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Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody

31 March 2020

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Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

31 March 2020

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

31 March 2020

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Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies

31 March 2020

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Modulation of proteinase-K resistant prion protein by prion peptide immunization.

31 March 2020

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Immunization delays the onset of prion disease in mice.

31 March 2020

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Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.

31 March 2020

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Immunization with recombinant prion protein leads to partial protection in a murine model of TSEs through a novel mechanism

31 March 2020

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DNA vaccination can break immunological tolerance to PrP in wild-type mice and attenuates prion disease after intracerebral challenge

31 March 2020

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Monoclonal antibodies inhibit prion replication and delay the development of prion disease

31 March 2020

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Anti-prion antibodies for prophylaxis following prion exposure in mice

31 March 2020

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Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo

31 March 2020

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Biological effects and use of PrPSc- and PrP-specific antibodies generated by immunization with purified full-length native mouse prions

31 March 2020

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Toxic effects of intracerebral PrP antibody administration during the course of BSE infection in mice

31 March 2020

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CNS delivery of vectored prion-specific single-chain antibodies delays disease onset

31 March 2020

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Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

31 March 2020

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The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

31 March 2020

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Turning off follicular dendritic cells

31 March 2020

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Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease

31 March 2020

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Mice with gene targetted prion protein alterations show that Prnp, Sinc and Prni are congruent

31 March 2020

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High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene

31 March 2020

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Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene

31 March 2020

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Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel

31 March 2020

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Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

31 March 2020

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Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

31 March 2020

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Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

31 March 2020

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Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques.

31 March 2020

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Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

31 March 2020

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Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions

31 March 2020

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De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis

31 March 2020

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

31 March 2020

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The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease

31 March 2020

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Memory impairment in transgenic Alzheimer mice requires cellular prion protein

31 March 2020

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

31 March 2020

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Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

31 March 2020

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Prion protein and Abeta-related synaptic toxicity impairment

31 March 2020

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The prion protein as a receptor for amyloid-beta.

31 March 2020

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Somatic mosaicism in a case of apparently sporadic Creutzfeldt-Jakob disease carrying a de novo D178N mutation in the PRNP gene

31 March 2020

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Immunisation with a synthetic prion protein-derived peptide prolongs survival times of mice orally exposed to the scrapie agent

31 March 2020

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High titers of mucosal and systemic anti-PrP antibodies abrogate oral prion infection in mucosal-vaccinated mice.

31 March 2020

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Intranasal immunization of Balb/c mice against prion protein attenuates orally acquired transmissible spongiform encephalopathy

31 March 2020

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Anti-prion activity generated by a novel vaccine formulation

31 March 2020

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Immunization with recombinant bovine but not mouse prion protein delays the onset of disease in mice inoculated with a mouse-adapted prion

31 March 2020

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Immunisation strategies against prion diseases: prime-boost immunisation with a PrP DNA vaccine containing foreign helper T-cell epitopes does not prevent mouse scrapie

31 March 2020

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Contribution of antibody and T cell-specific responses to the progression of 139A-scrapie in C57BL/6 mice immunized with prion protein peptides

31 March 2020

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Unswitched immunoglobulin M response prolongs mouse survival in prion disease.

31 March 2020

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Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie.

31 March 2020

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Mouse vaccination with dendritic cells loaded with prion protein peptides overcomes tolerance and delays scrapie

31 March 2020

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Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice

31 March 2020

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Immunotherapy in prion disease

31 March 2020

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Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute-phase response gene expression in scrapie

31 March 2020

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12 December 2020

Microglial activation varies in different models of Creutzfeldt-Jakob disease.

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12 December 2020

Temporal distribution of transmissible mink encephalopathy virus in mink inoculated subcutaneously

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12 December 2020

Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS

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12 December 2020

Multiplication of scrapie agent in mouse spleen

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12 December 2020

Isolation from Mouse Spleen of Cell Populations with High Specific Infectivity for Scrapie Virus

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12 December 2020

Evidence for normal cell-mediated immunity in scrapie-infected mice

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12 December 2020

Immune system-dependent and -independent replication of the scrapie agent

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12 December 2020

Failure to demonstrate a humoral immune response to scrapie infection in mice

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12 December 2020

Pathogenesis of natural scrapie in sheep

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12 December 2020

Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease

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12 December 2020

Letter: Possible person-to-person transmission of Creutzfeldt-Jakob disease

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12 December 2020

Identifiers

DOI

10.1038/NRI3553

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30 August 2017

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