The roles of K(+) channels in cancer (Q38171243)

30 August 2017

title

The roles of K(+) channels in cancer (English)

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30 August 2017

Luis A Pardo

1

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author name string

Walter Stühmer

series ordinal

2

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30 August 2017

language of work or name

English

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publication date

12 December 2013

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30 August 2017

published in

Nature Reviews Cancer

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30 August 2017

volume

14

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30 August 2017

issue

1

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30 August 2017

page(s)

39-48

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Voltage-gated potassium channels as therapeutic targets

30 August 2017

cites work

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Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors

31 March 2020

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A voltage-driven switch for ion-independent signaling by ether-à-go-go K+ channels

31 March 2020

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International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels

31 March 2020

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Non-conducting functions of voltage-gated ion channels

31 March 2020

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K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension

31 March 2020

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HERG K+ channels activation during beta(1) integrin-mediated adhesion to fibronectin induces an up-regulation of alpha(v)beta(3) integrin in the preosteoclastic leukemia cell line FLG 29.1.

31 March 2020

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Stimulation of HERG channel activity by β-catenin

31 March 2020

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p38 MAPK regulates the expression of ether à go-go potassium channel in human osteosarcoma cells

31 March 2020

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The two-pore domain potassium channel KCNK5: induction by estrogen receptor alpha and role in proliferation of breast cancer cells.

31 March 2020

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Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas

31 March 2020

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A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3.

31 March 2020

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Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels

31 March 2020

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Deregulation of 2 potassium channels in pancreas adenocarcinomas: implication of KV1.3 gene promoter methylation.

31 March 2020

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DNA methylation of K(v)1.3 potassium channel gene promoter is associated with poorly differentiated breast adenocarcinoma.

31 March 2020

1 reference

DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients

31 March 2020

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Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel

31 March 2020

1 reference

Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implications.

31 March 2020

1 reference

Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation

31 March 2020

1 reference

Transcriptional and post-transcriptional mechanisms for oncogenic overexpression of ether à go-go K+ channel

31 March 2020

1 reference

Estrogens and human papilloma virus oncogenes regulate human ether-à-go-go-1 potassium channel expression.

31 March 2020

1 reference

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

31 March 2020

1 reference

Human papillomavirus type 16 E7 binds to E2F1 and activates E2F1-driven transcription in a retinoblastoma protein-independent manner

31 March 2020

1 reference

IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation

31 March 2020

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Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

31 March 2020

1 reference

MiR-296-3p regulates cell growth and multi-drug resistance of human glioblastoma by targeting ether-à-go-go (EAG1).

31 March 2020

1 reference

MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region

31 March 2020

1 reference

Expression of Voltage-Gated Potassium Channels in Human and Mouse Colonic Carcinoma

31 March 2020

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Oncogenic potential of EAG K(+) channels

31 March 2020

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Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice

31 March 2020

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Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain

31 March 2020

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Overexpression of Eag1 potassium channels in clinical tumours.

31 March 2020

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Ether à go-go potassium channel expression in soft tissue sarcoma patients

31 March 2020

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The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia

31 March 2020

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The Eag potassium channel as a new prognostic marker in ovarian cancer

31 March 2020

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Aberrant expression of Eag1 potassium channels in gastric cancer patients and cell lines

31 March 2020

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Aberrant expression of ether à go-go potassium channel in colorectal cancer patients and cell lines

31 March 2020

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Differential expression of potassium ion channels in human renal cell carcinoma

31 March 2020

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Monoclonal Antibody Blockade of the Human Eag1 Potassium Channel Function Exerts Antitumor Activity

31 March 2020

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Tumor cell-selective apoptosis induction through targeting of K(V)10.1 via bifunctional TRAIL antibody.

31 March 2020

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Role of ion channels and transporters in cell migration

31 March 2020

1 reference

Focal adhesion kinase pp125FAK interacts with the large conductance calcium-activated hSlo potassium channel in human osteoblasts: potential role in mechanotransduction.

31 March 2020

1 reference

Formation of Kv2.1-FAK complex as a mechanism of FAK activation, cell polarization and enhanced motility

31 March 2020

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Cortactin is required for N-cadherin regulation of Kv1.5 channel function

31 March 2020

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Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin

31 March 2020

1 reference

The TASK1 channel inhibitor A293 shows efficacy in a mouse model of multiple sclerosis

31 March 2020

1 reference

A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin

31 March 2020

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An essential role for cortactin in the modulation of the potassium channel Kv1.2.

31 March 2020

1 reference

Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins

31 March 2020

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Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling

31 March 2020

1 reference

VEGFR-1 (FLT-1), beta1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome

31 March 2020

1 reference

The role of hERG1 K+ channels and a functional link between hERG1 K+ channels and SDF-1 in acute leukemic cell migration

31 March 2020

1 reference

Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration

31 March 2020

1 reference

Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells

31 March 2020

1 reference

A novel inward-rectifying K+ current with a cell-cycle dependence governs the resting potential of mammalian neuroblastoma cells

31 March 2020

1 reference

HERG- and IRK-like inward rectifier currents are sequentially expressed during neuronal development of neural crest cells and their derivatives

31 March 2020

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HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors.

31 March 2020

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Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells

31 March 2020

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herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells.

31 March 2020

1 reference

Expression and significance of HERG protein in gastric cancer

31 March 2020

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Prognostic significance of hERG1 expression in gastric cancer.

31 March 2020

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HERG1 gene expression as a specific tumor marker in colorectal tissues

31 March 2020

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Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cells

31 March 2020

1 reference

Role of HERG1 potassium channel in both malignant transformation and disease progression in head and neck carcinomas.

31 March 2020

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hERG1 channels in human esophagus: evidence for their aberrant expression in the malignant progression of Barrett's esophagus.

31 March 2020

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hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines

31 March 2020

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Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells

31 March 2020

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The potent inhibitory effects of cisapride, a specific blocker for human ether-a-go-go-related gene (HERG) channel, on gastric cancer cells

31 March 2020

1 reference

Silencing of herg gene by shRNA inhibits SH-SY5Y cell growth in vitro and in vivo

31 March 2020

1 reference

hERG K(+) channels: structure, function, and clinical significance

31 March 2020

1 reference

Identification of a posttranslational mechanism for the regulation of hERG1 K+ channel expression and hERG1 current density in tumor cells

31 March 2020

1 reference

Oscillating activity of a Ca(2+)-sensitive K+ channel. A prerequisite for migration of transformed Madin-Darby canine kidney focus cells

31 March 2020

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Migrating transformed MDCK cells are able to structurally polarize a voltage-activated K+ channel

31 March 2020

1 reference

K(+) channel-dependent migration of fibroblasts and human melanoma cells

31 March 2020

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Migration of transformed renal epithelial cells is regulated by K+ channel modulation of actin cytoskeleton and cell volume

31 March 2020

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Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release

31 March 2020

1 reference

Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cells

31 March 2020

1 reference

CXCL12-induced glioblastoma cell migration requires intermediate conductance Ca2+-activated K+ channel activity

31 March 2020

1 reference

The inhibition of KCa3.1 channels activity reduces cell motility in glioblastoma derived cancer stem cells.

31 March 2020

1 reference

Ionizing radiation induces migration of glioblastoma cells by activating BK K(+) channels

31 March 2020

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Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells

31 March 2020

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KCa2.3 channel-dependent hyperpolarization increases melanoma cell motility.

31 March 2020

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Identification of SK3 channel as a new mediator of breast cancer cell migration

31 March 2020

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New alkyl-lipid blockers of SK3 channels reduce cancer cell migration and occurrence of metastasis.

31 March 2020

1 reference

Human ether à-gogo K(+) channel 1 (hEag1) regulates MDA-MB-231 breast cancer cell migration through Orai1-dependent calcium entry

31 March 2020

1 reference

Pivotal role of the lipid Raft SK3-Orai1 complex in human cancer cell migration and bone metastases.

31 March 2020

1 reference

Cell volume homeostatic mechanisms: effectors and signalling pathways

31 March 2020

1 reference

Ion channels involved in cell volume regulation: effects on migration, proliferation, and programmed cell death in non adherent EAT cells and adherent ELA cells

31 March 2020

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Involvement of K+ channels in the quercetin-induced inhibition of neuroblastoma cell growth.

31 March 2020

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Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics

31 March 2020

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Rat aortic smooth muscle cells expressing charybdotoxin-sensitive potassium channels exhibit enhanced proliferative responses

31 March 2020

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Blockade of Ca2+-activated K+ channels inhibits proliferation of human endothelial cells induced by basic fibroblast growth factor

31 March 2020

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Vascular endothelial growth factor-A activates Ca2+ -activated K+ channels in human endothelial cells in culture

31 March 2020

1 reference

Potassium channels and vascular proliferation

31 March 2020

1 reference

Cell cycle-dependent expression of Kv3.4 channels modulates proliferation of human uterine artery smooth muscle cells

31 March 2020

1 reference

Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers

31 March 2020

1 reference

Kv1.3 channels can modulate cell proliferation during phenotypic switch by an ion-flux independent mechanism.

31 March 2020

1 reference

The intermediate conductance calcium-activated potassium channel KCa3.1 regulates vascular smooth muscle cell proliferation via controlling calcium-dependent signaling

31 March 2020

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KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells

31 March 2020

1 reference

Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104

31 March 2020

1 reference

Hallmarks of Cancer: The Next Generation

31 March 2020

1 reference

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

31 March 2020

1 reference

Bioelectric controls of cell proliferation: ion channels, membrane voltage and the cell cycle

31 March 2020

1 reference

The functional network of ion channels in T lymphocytes

31 March 2020

1 reference

Intermediate Ca2+-sensitive K+ channels are necessary for prolactin-induced proliferation in breast cancer cells

31 March 2020

1 reference

Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry

31 March 2020

1 reference

Ion channels and the hallmarks of cancer

31 March 2020

1 reference

Controlling the cell cycle: the role of calcium/calmodulin-stimulated protein kinases I and II.

31 March 2020

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Regulation of cell cycle progression by calcium/calmodulin-dependent pathways

31 March 2020

1 reference

The 2P-domain K+ channels: role in apoptosis and tumorigenesis

31 March 2020

1 reference

Differential role of IK and BK potassium channels as mediators of intrinsic and extrinsic apoptotic cell death.

31 March 2020

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Intracellular K+ concentration decrease is not obligatory for apoptosis

31 March 2020

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Ion channel inhibitors block caspase activation by mechanisms other than restoring intracellular potassium concentration

31 March 2020

1 reference

Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect

31 March 2020

1 reference

Glibenclamide exerts an antitumor activity through reactive oxygen species-c-jun NH2-terminal kinase pathway in human gastric cancer cell line MGC-803.

31 March 2020

1 reference

The protective roles of mitochondrial ATP-sensitive potassium channels during hypoxia-ischemia-reperfusion in brain

31 March 2020

1 reference

Mitochondrial ROMK channel is a molecular component of mitoK(ATP)

31 March 2020

1 reference

TASK-3, a new member of the tandem pore K(+) channel family

31 March 2020

1 reference

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene

31 March 2020

1 reference

Reduction of breast cancer cell migration via up-regulation of TASK-3 two-pore domain K+ channel

31 March 2020

1 reference

Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function

31 March 2020

1 reference

K+-dependent cerebellar granule neuron apoptosis. Role of task leak K+ channels.

31 March 2020

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The two-pore domain potassium channel TASK3 functionally impacts glioma cell death.

31 March 2020

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Mitochondrial expression of the two-pore domain TASK-3 channels in malignantly transformed and non-malignant human cells.

31 March 2020

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Actinomycin D-induced apoptosis involves the potassium channel Kv1.3.

31 March 2020

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Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

31 March 2020

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Role of Kv1.3 mitochondrial potassium channel in apoptotic signalling in lymphocytes.

31 March 2020

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Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells

31 March 2020

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Induction of apoptosis in macrophages via Kv1.3 and Kv1.5 potassium channels.

31 March 2020

1 reference

An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca2+-activated K+ channel mtKCa3.1.

31 March 2020

1 reference

Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers.

31 March 2020

1 reference

Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: role for ATP-sensitive K+ channels and endoplasmic reticulum stress

31 March 2020

1 reference

State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy

31 March 2020

1 reference

HERG K+ channel expression-related chemosensitivity in cancer cells and its modulation by erythromycin

31 March 2020

1 reference

Eag and HERG potassium channels as novel therapeutic targets in cancer

31 March 2020

1 reference

An unexpected role for ion channels in brain tumor metastasis

31 March 2020

1 reference

A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

31 March 2020

1 reference

Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking

31 March 2020

1 reference

Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1.

31 March 2020

1 reference

Ether a go-go potassium channels as human cervical cancer markers

31 March 2020

1 reference

Human ether-à-go-go-related gene expression is essential for cisplatin to induce apoptosis in human gastric cancer

31 March 2020

1 reference

12 December 2020

BK channels in human glioma cells have enhanced calcium sensitivity

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12 December 2020

Physical and functional interaction between integrins and hERG1 channels in cancer cells

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12 December 2020

The influence of cell volume changes on tumour cell proliferation

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12 December 2020

Integrins and ion channels in cell migration: implications for neuronal development, wound healing and metastatic spread

1 reference

12 December 2020

HERG K+ channel related chemosensitivity to sparfloxacin in colon cancer cells.

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12 December 2020

Diazoxide preconditioning alleviates apoptosis of hippocampal neurons induced by anoxia-reoxygenation in vitro through up-regulation of Bcl-2/Bax protein ratio.

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12 December 2020

Potassium channels in cell cycle and cell proliferation.

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12 December 2020

Expression and prognostic significance of the oncogenic K2P potassium channel KCNK9 (TASK-3) in ovarian carcinoma

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12 December 2020

Cell volume regulation in renal cortical cells

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12 December 2020

Expression and Role of the Intermediate-Conductance Calcium-Activated Potassium Channel KCa3.1 in Glioblastoma.

1 reference

12 December 2020

Eag1 potassium channels as markers of cervical dysplasia.

1 reference

12 December 2020

Changes in the K+ current-density of MCF-7 cells during progression through the cell cycle: possible involvement of a h-ether.a-gogo K+ channel.

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12 December 2020

Potassium channels keep mobile cells on the go.

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12 December 2020

herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?

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12 December 2020

Identifiers

DOI

10.1038/NRC3635

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Dimensions Publication ID

30 August 2017

1042579945

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