Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs (Q38550011)

4 September 2017

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title

Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs (English)

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4 September 2017

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R J Reid

1

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4 September 2017

P Benedetti

series ordinal

2

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4 September 2017

M A Bjornsti

series ordinal

3

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4 September 2017

language of work or name

English

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publication date

1 October 1998

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Biochimica et Biophysica Acta

4 September 2017

published in

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4 September 2017

volume

1400

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4 September 2017

issue

1-3

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4 September 2017

page(s)

289-300

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SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I

4 September 2017

cites work

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7 January 2021

Yeast Saccharomyces cerevisiae as a model system to study the cytotoxic activity of the antitumor drug camptothecin

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7 January 2021

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7 January 2021

A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase

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7 January 2021

Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II.

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7 January 2021

A novel family of TRF (DNA topoisomerase I-related function) genes required for proper nuclear segregation

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7 January 2021

DNA topoisomerases: essential enzymes and lethal targets

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7 January 2021

Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism

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7 January 2021

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

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7 January 2021

Camptothecin sensitivity is mediated by the pleiotropic drug resistance network in yeast.

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7 January 2021

Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy

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7 January 2021

Study of yeast DNA topoisomerase II and its truncation derivatives by transmission electron microscopy

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7 January 2021

Structure and mechanism of DNA topoisomerase II

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7 January 2021

Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

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7 January 2021

A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

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7 January 2021

A mutation in yeast TOP2 homologous to a quinolone-resistant mutation in bacteria. Mutation of the amino acid homologous to Ser83 of Escherichia coli gyrA alters sensitivity to eukaryotic topoisomerase inhibitors

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7 January 2021

Increased drug affinity as the mechanistic basis for drug hypersensitivity of a mutant type II topoisomerase

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7 January 2021

Complementation of temperature-sensitive topoisomerase II mutations in Saccharomyces cerevisiae by a human TOP2 beta construct allows the study of topoisomerase II beta inhibitors in yeast

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7 January 2021

Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms

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7 January 2021

Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.

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7 January 2021

A camptothecin-resistant DNA topoisomerase I mutant exhibits altered sensitivities to other DNA topoisomerase poisons

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7 January 2021

A 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications

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7 January 2021

A model for the mechanism of human topoisomerase I

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7 January 2021

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

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7 January 2021

Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli

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7 January 2021

Purification and characterization of human topoisomerase I mutants

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7 January 2021

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death

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7 January 2021

The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae

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7 January 2021

Yeast multidrug resistance: The PDR network

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7 January 2021

10.1016/S0167-4781(98)00142-0

Identifiers

DOI

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4 September 2017

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