Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines (Q38576762)

4 September 2017

1 reference

8 February 2021

Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines (English)

1 reference

antineoplastic antibiotics

4 September 2017

anthracycline polyketide

1 reference

18 November 2019

1 reference

8 February 2021

1 reference

PubMed publication ID

26321196

author name string

Derek W Edwardson

1

1 reference

4 September 2017

Rashmi Narendrula

2

1 reference

4 September 2017

Simon Chewchuk

3

1 reference

4 September 2017

Kyle Mispel-Beyer

4

1 reference

4 September 2017

Jonathan P J Mapletoft

5

1 reference

4 September 2017

Amadeo M Parissenti

6

1 reference

4 September 2017

language of work or name

English

0 references

publication date

31 August 2015

1 reference

4 September 2017

Current Drug Metabolism

6 references

4 September 2017

3 April 2019

7 November 2019

13 November 2019

18 November 2019

8 February 2021

16

1 reference

4 September 2017

6

1 reference

4 September 2017

412-426

1 reference

Creative Commons Attribution-NonCommercial

4 September 2017

5 references

3 April 2019

7 November 2019

13 November 2019

18 November 2019

8 February 2021

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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6 September 2017

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Identification of the molecular basis of doxorubicin-induced cardiotoxicity

6 September 2017

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Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization.

6 September 2017

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Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies

6 September 2017

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Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.

6 September 2017

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NADPH oxidase-dependent oxidative stress in the failing heart: From pathogenic roles to therapeutic approach

6 September 2017

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Cardioprotective effect of ascorbic acid on doxorubicin-induced myocardial toxicity in rats

6 September 2017

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A switching mechanism in doxorubicin bioactivation can be exploited to control doxorubicin toxicity

6 September 2017

1 reference

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Functional characterization of drug uptake and metabolism in the heart

6 September 2017

1 reference

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Anthracyclines and ellipticines as DNA-damaging anticancer drugs: recent advances

6 September 2017

1 reference

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NAD(P)H: quinone oxidoreductase 1 and its potential protective role in cardiovascular diseases and related conditions

6 September 2017

1 reference

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Long-term toxic effects of adjuvant chemotherapy in breast cancer.

6 September 2017

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Dexrazoxane as a cardioprotectant in children receiving anthracyclines

6 September 2017

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Nox2 NADPH oxidase promotes pathologic cardiac remodeling associated with Doxorubicin chemotherapy

6 September 2017

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Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin

6 September 2017

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Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?

6 September 2017

1 reference

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Discovery of the negative regulator of Nrf2, Keap1: a historical overview

6 September 2017

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The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor

6 September 2017

1 reference

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Different dosage schedules for reducing cardiotoxicity in cancer patients receiving anthracycline chemotherapy

6 September 2017

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Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron

6 September 2017

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Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro

6 September 2017

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Expert opinion on the use of anthracyclines in patients with advanced breast cancer at cardiac risk

6 September 2017

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Re: Therapy Insight: anthracyclines and trastuzumab--the optimal management of cardiotoxic side effects.

6 September 2017

1 reference

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Cellular mechanisms of resistance to anthracyclines and taxanes in cancer: intrinsic and acquired

6 September 2017

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The effect of monohydroxyethylrutoside on doxorubicin-induced cardiotoxicity in patients treated for metastatic cancer in a phase II study

6 September 2017

1 reference

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Role of anthracyclines in the era of targeted therapy

6 September 2017

1 reference

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Aldo-keto reductases and bioactivation/detoxication.

6 September 2017

1 reference

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Preventing the cardiotoxic effects of anthracyclins. From basic concepts to clinical data

6 September 2017

1 reference

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Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness

6 September 2017

1 reference

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Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors

6 September 2017

1 reference

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Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity

6 September 2017

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The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage

6 September 2017

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Energy metabolism in heart failure

6 September 2017

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Microsomal triphosphopyridine nucleotide-cytochrome c reductase of liver.

6 September 2017

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Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase

6 September 2017

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The proton-translocating NADH-quinone oxidoreductase in the respiratory chain: the secret unlocked

6 September 2017

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Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

6 September 2017

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NQO1 stabilizes p53 through a distinct pathway

6 September 2017

1 reference

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A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: distribution and efficacy in experimental human ovarian cancer

6 September 2017

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A guide to 17beta-hydroxysteroid dehydrogenases

6 September 2017

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Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1.

6 September 2017

1 reference

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Human carbonyl reductase overexpression in the heart advances the development of doxorubicin-induced cardiotoxicity in transgenic mice.

6 September 2017

1 reference

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Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members

6 September 2017

1 reference

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A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin

6 September 2017

1 reference

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Presence of a heterozygous substitution and its relationship to DT-diaphorase activity

6 September 2017

1 reference

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The L-arginine-nitric oxide pathway

6 September 2017

1 reference

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Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components

6 September 2017

1 reference

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A clinicopathologic analysis of adriamycin cardiotoxicity

6 September 2017

1 reference

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Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6

6 September 2017

1 reference

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Ferritin, lipid peroxidation and redox-cycling xenobiotics

6 September 2017

1 reference

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The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-κB.

6 September 2017

1 reference

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Micro-PET imaging of beta-glucuronidase activity by the hydrophobic conversion of a glucuronide probe

14 September 2017

1 reference

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Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Neutropenia and febrile neutropenia in patients with Hodgkin's lymphoma treated with doxorubicin (Adriamycin), bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy.

14 September 2017

1 reference

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Inactivation of anthracyclines by cellular peroxidase.

14 September 2017

1 reference

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The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines.

14 September 2017

1 reference

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Pronounced antitumor efficacy by extracellular activation of a doxorubicin-glucuronide prodrug after adenoviral vector-mediated expression of a human antibody-enzyme fusion protein

14 September 2017

1 reference

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Interactions of adriamycin aglycones with mitochondria may mediate adriamycin cardiotoxicity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase. Effect of antiapoptotic antioxidants and calcium

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Proteasome is a carrier to translocate doxorubicin from cytoplasm into nucleus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Nitric oxide: a physiologic messenger

27 September 2017

1 reference

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Cardiac toxicity 4 to 20 years after completing anthracycline therapy

27 September 2017

1 reference

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Anthracyclines and their C-13 alcohol metabolites: growth inhibition and DNA damage following incubation with human tumor cells in culture

27 September 2017

1 reference

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An alternative concept for the molecular nature of the peroxidating ability of anthracycline anti-tumor antibiotics and anthracenodiones

27 September 2017

1 reference

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Chronic heart damage following doxorubicin treatment is alleviated by lovastatin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

23 June 2018

1 reference

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Bacterial inactivation of the anticancer drug doxorubicin.

23 June 2018

1 reference

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Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor

23 June 2018

1 reference

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Secreted human beta-glucuronidase: a novel tool for gene-directed enzyme prodrug therapy

23 June 2018

1 reference

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The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines.

23 June 2018

1 reference

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The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

23 June 2018

1 reference

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Anthracyclines in the treatment of cancer. An overview

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Thiol-dependent DNA damage produced by anthracycline-iron complexes. The structure-activity relationships and molecular mechanisms.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Free radicals induced by adriamycin-sensitive and adriamycin-resistant cells: a spin-trapping study.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Microsomal iron-dependent NADPH oxidation: evidence for the involvement of membrane-bound nonheme iron in NADPH oxidation by rat heart microsomes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Induction and potential biological relevance of a Ca(2+)-independent nitric oxide synthase in the myocardium

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Anthracycline antibiotic pharmacology and metabolism

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Phase I and pharmacokinetic study of the novel anthracycline derivative 5-imino-13-deoxydoxorubicin (GPX-150) in patients with advanced solid tumors

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

The decrease of NAD(P)H:quinone oxidoreductase 1 activity and increase of ROS production by NADPH oxidases are early biomarkers in doxorubicin cardiotoxicity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Effect of statin therapy on the risk for incident heart failure in patients with breast cancer receiving anthracycline chemotherapy: an observational clinical cohort study

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Chronic anthracycline cardiotoxicity: molecular and functional analysis with focus on nuclear factor erythroid 2-related factor 2 and mitochondrial biogenesis pathways.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2-mediated cellular defense response

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Fullerenol C60(OH)24 prevents doxorubicin-induced acute cardiotoxicity in rats.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Cardioprotective effect of metoprolol and enalapril in doxorubicin‐treated lymphoma patients: A prospective, parallel‐group, randomized, controlled study with 36‐month follow‐up

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

In vitro and in vivo study on the antioxidant activity of dexrazoxane

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

NADPH oxidases participate to doxorubicin-induced cardiac myocyte apoptosis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Acute doxorubicin pulmotoxicity in rats with malignant neoplasm is effectively treated with fullerenol C60(OH)24 through inhibition of oxidative stress.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

ACE inhibition and protection from doxorubicin-induced cardiotoxicity in the rat.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Acute doxorubicin nephrotoxicity in rats with malignant neoplasm can be successfully treated with fullerenol C60(OH)24 via suppression of oxidative stress

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Mechanism of DNA damage and apoptosis induced by anticancer drugs through generation of reactive oxygen species

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Multicenter randomized phase III study of the cardioprotective effect of dexrazoxane (Cardioxane) in advanced/metastatic breast cancer patients treated with anthracycline-based chemotherapy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Long-term cardiac toxicity after adjuvant epirubicin-based chemotherapy in early breast cancer: French Adjuvant Study Group results

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Localization and altered expression of AKR1C family members in human ovarian tissues

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

The effect of new lipophilic chelators on the activities of cytosolic reductases and P450 cytochromes involved in the metabolism of anthracycline antibiotics: studies in vitro.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Human neuronal nitric oxide synthase can catalyze one-electron reduction of adriamycin: role of flavin domain

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Protection from doxorubicin-induced cardiac toxicity in mice with a null allele of carbonyl reductase 1

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Rapid-onset endothelial dysfunction with adriamycin: evidence for a dysfunctional nitric oxide synthase

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Enzymatic oxidation of some non-phosphorylated derivatives of dihydronicotinamide.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Anthracycline secondary alcohol metabolite formation in human or rabbit heart: biochemical aspects and pharmacologic implications.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Differential Ability of Cytostatics From Anthraquinone Group to Generate Free Radicals in Three Enzymatic Systems: NADH Dehydrogenase, NADPH Cytochrome P450 Reductase, and Xanthine Oxidase

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Metabolic activation of adriamycin by NADPH-cytochrome P450 reductase; overview of its biological and biochemical effects.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Design and baseline characteristics for the ACE Inhibitor After Anthracycline (AAA) study of cardiac dysfunction in long-term pediatric cancer survivors

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Baroreflex sensitivity and oxidative stress in adriamycin-induced heart failure

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Abnormal cardiac and skeletal muscle mitochondrial function in pacing-induced cardiac failure

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Effects of doxorubicinol on excitation--contraction coupling in guinea pig ventricular myocytes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Mechanism of specific nuclear transport of adriamycin: the mode of nuclear translocation of adriamycin-proteasome complex

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Modulation of the calcium release channel of sarcoplasmic reticulum by adriamycin and other drugs.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5398089

Doxorubicin metabolism and toxicity in human myocardium: role of cytoplasmic deglycosidation and carbonyl reduction

31 August 2018

1 reference

12 December 2020

Pharmacokinetics and metabolism of iodo-doxorubicin and doxorubicin in humans

1 reference

12 December 2020

Doxorubicin-induced acute changes in cytotoxic aldehydes, antioxidant status and cardiac function in the rat

1 reference

12 December 2020

The quenching of singlet oxygen by amino acids and proteins

1 reference

12 December 2020

N-Benzyladriamycin-14-valerate (AD 198): a non-cardiotoxic anthracycline that is cardioprotective through PKC-epsilon activation

1 reference

12 December 2020

Release of iron from ferritin by cardiotoxic anthracycline antibiotics

1 reference

12 December 2020

DNA damage and cytotoxicity induced by metabolites of anthracycline antibiotics, doxorubicin and idarubicin

1 reference

12 December 2020

Alterations in expression of CYP1A1 and NADPH-cytochrome P450 reductase during lung tumor development in SWR/J mice

1 reference

12 December 2020

Tissue distribution of doxorubicin and doxorubicinol in rats receiving multiple doses of doxorubicin

1 reference

12 December 2020

Incidence and risk-factors of CHOP/R-CHOP-related cardiotoxicity in patients with aggressive non-Hodgkin's lymphoma

1 reference

12 December 2020

Comparative mammalian metabolism of adriamycin and daunorubicin

1 reference

12 December 2020

Role of iron in anthracycline cardiotoxicity: new tunes for an old song?

1 reference

12 December 2020

Anticancer derivative of butyric acid (Pivalyloxymethyl butyrate) specifically potentiates the cytotoxicity of doxorubicin and daunorubicin through the suppression of microsomal glycosidic activity

1 reference

12 December 2020

Nitric oxide synthase expressions in ADR-induced cardiomyopathy in rats

1 reference

12 December 2020

Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3

1 reference

12 December 2020

C(60) and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation

1 reference

12 December 2020

Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity

1 reference

12 December 2020

Daunorubicin cardiotoxicity: evidence for the importance of the quinone moiety in a free-radical-independent mechanism

1 reference

12 December 2020

The enzymology of doxorubicin quinone reduction in tumour tissue

1 reference

12 December 2020

Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia

1 reference

12 December 2020

Letter by Hammoud et al regarding article "Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition"

1 reference

12 December 2020

The consequences of doxorubicin quinone reduction in vivo in tumour tissue

1 reference

12 December 2020

Role of xanthine oxidase in the potentiation of doxorubicin-induced cardiotoxicity by mitomycin C

1 reference

12 December 2020

Single-nucleotide polymorphisms in aldo-keto and carbonyl reductase genes are not associated with acute cardiotoxicity after daunorubicin chemotherapy

1 reference

12 December 2020

Uptake and intracellular distribution of doxorubicin metabolites in B-lymphocytes of chronic lymphocytic leukemia

1 reference

12 December 2020

Anthracycline cardiotoxicity

1 reference

12 December 2020

Endothelial dysfunction does not require loss of endothelial nitric oxide synthase

1 reference

12 December 2020

Enhancement of doxorubicin toxicity following activation by NADPH cytochrome P450 reductase

1 reference

12 December 2020

Enhanced uptake of doxorubicin into bronchial carcinoma: beta-glucuronidase mediates release of doxorubicin from a glucuronide prodrug (HMR 1826) at the tumor site

1 reference

12 December 2020

1 reference

12 December 2020

10.2174/1389200216888150915112039

Identifiers

DOI

1 reference

4 September 2017

1 reference

4 September 2017

PubMed publication ID

26321196

1 reference