Small molecule probes for cellular death machines (Q39383323)

11 September 2017

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title

Small molecule probes for cellular death machines (English)

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11 September 2017

Ying Li

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC5581716&resulttype=core&format=json

14 May 2020

Lihui Qian

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC5581716&resulttype=core&format=json

14 May 2020

Junying Yuan

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC5581716&resulttype=core&format=json

14 May 2020

publication date

16 June 2017

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28628894

Current Opinion in Chemical Biology

11 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC5581716&resulttype=core&format=json

14 May 2020

volume

39

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC5581716&resulttype=core&format=json

14 May 2020

page(s)

74-82

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC5581716&resulttype=core&format=json

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

14 May 2020

cites work

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12 December 2020

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.

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12 December 2020

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

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12 December 2020

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

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12 December 2020

Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

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12 December 2020

HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.

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12 December 2020

Resistance to cisplatin.

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12 December 2020

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.

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12 December 2020

Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells

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12 December 2020

Ferroptosis: an iron-dependent form of nonapoptotic cell death

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12 December 2020

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

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12 December 2020

Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo.

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12 December 2020

Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

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12 December 2020

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

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12 December 2020

Regulated necrosis: disease relevance and therapeutic opportunities

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12 December 2020

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

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12 December 2020

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

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12 December 2020

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12 December 2020

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

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12 December 2020

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

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12 December 2020

SnapShot: Necroptosis.

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12 December 2020

Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1.

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12 December 2020

Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

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12 December 2020

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

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12 December 2020

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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12 December 2020

Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis.

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12 December 2020

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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12 December 2020

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

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12 December 2020

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

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12 December 2020

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

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12 December 2020

Ferroptosis and cell death mechanisms in Parkinson's disease.

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12 December 2020

DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.

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12 December 2020

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

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12 December 2020

Regulation of ferroptotic cancer cell death by GPX4

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12 December 2020

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

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12 December 2020

A novel role for RIP1 kinase in mediating TNFα production

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12 December 2020

Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease

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12 December 2020

Glutathione peroxidase 4 is required for maturation of photoreceptor cells

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12 December 2020

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.

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12 December 2020

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

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12 December 2020

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

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12 December 2020

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

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12 December 2020

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

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12 December 2020

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

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12 December 2020

Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones

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12 December 2020

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

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12 December 2020

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

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12 December 2020

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.

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12 December 2020

Glutathione redox system in oxidative lung injury

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12 December 2020

Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation

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12 December 2020

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

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12 December 2020

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

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12 December 2020

Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model

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12 December 2020

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis

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12 December 2020

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

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12 December 2020

Identification of RIP1 kinase as a specific cellular target of necrostatins

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12 December 2020

Herpes Simplex Virus 1 (HSV-1) and HSV-2 Mediate Species-Specific Modulations of Programmed Necrosis through the Viral Ribonucleotide Reductase Large Subunit R1

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12 December 2020

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

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12 December 2020

Cell membrane permeabilization and cellular collapse, followed by loss of dehydrogenase activity: early events in tumour necrosis factor-induced cytotoxicity

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12 December 2020

Necroptosis in health and diseases

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12 December 2020

Apoptosis and glutathione: beyond an antioxidant.

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12 December 2020

The role of iron and reactive oxygen species in cell death

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12 December 2020

Structural basis of RIP1 inhibition by necrostatins

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12 December 2020

Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis

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12 December 2020

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

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12 December 2020

Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase

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12 December 2020

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

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12 December 2020

Glutaminolysis and Transferrin Regulate Ferroptosis

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12 December 2020

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

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12 December 2020

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

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12 December 2020

RIP3 induces apoptosis independent of pronecrotic kinase activity

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12 December 2020

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

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12 December 2020

Synchronized renal tubular cell death involves ferroptosis.

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12 December 2020

Activation of necroptosis in multiple sclerosis

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12 December 2020

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

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12 December 2020

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

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12 December 2020

Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.

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12 December 2020

K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo.

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12 December 2020

Glutathione, iron and Parkinson's disease

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12 December 2020

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

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12 December 2020

DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors

1 reference

12 December 2020

10.1016/J.CBPA.2017.05.007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC5581716&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC5581716&resulttype=core&format=json

14 May 2020

28628894

1 reference