Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease (Q30482741)

16 August 2017

Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease (English)

1 reference

16 August 2017

0 references

Giovanna R Mallucci

6

1 reference

ORCID Public Data File 2021

author name string

Melanie D White

1

1 reference

16 August 2017

Michael Farmer

2

1 reference

16 August 2017

Ilaria Mirabile

3

1 reference

16 August 2017

Sebastian Brandner

4

1 reference

16 August 2017

John Collinge

5

1 reference

16 August 2017

language of work or name

English

0 references

publication date

16 July 2008

1 reference

Proceedings of the National Academy of Sciences of the United States of America

16 August 2017

1 reference

16 August 2017

105

1 reference

16 August 2017

29

1 reference

16 August 2017

10238-10243

1 reference

Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter.

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Lentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAi

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

AAV2-mediated gene delivery to monkey putamen: evaluation of an infusion device and delivery parameters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Efficient and specific down-regulation of prion protein expression by RNAi

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Specific inhibition of pathological prion protein accumulation by small interfering RNAs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Impaired recognition memory in rats after damage to the hippocampus.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Mice devoid of PrP are resistant to scrapie

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

No propagation of prions in mice devoid of PrP.

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Differences in transductional tropism of adenoviral and lentiviral vectors in the rat brainstem

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Burrowing into prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Comparison of the neuropathological characteristics of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Efficient gene transfer via retrograde transport in rodent and primate brains using a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Differential characteristics of HIV-based versus SIV-based lentiviral vector systems: Gene delivery to neurons and axonal transport of expressed gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

A Requirement for the Immediate Early Gene zif268 in Reconsolidation of Recognition Memory after Retrieval

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0802759105

Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2474561

Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18632556

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0802759105

1 reference

16 August 2017

0 references

1 reference

16 August 2017

PubMed publication ID

18632556

1 reference