BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer (Q33252066)

24 July 2017

title

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer (English)

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24 July 2017

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10

Funda Meric-Bernstam

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24 July 2017

5

Koei Chin

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24 July 2017

9

Gordon B Mills

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24 July 2017

6

Joe Gray

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24 July 2017

Rekha Rai

1

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24 July 2017

Hui Dai

2

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24 July 2017

Asha S Multani

3

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24 July 2017

Kaiyi Li

4

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24 July 2017

John P Lahad

7

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24 July 2017

Jiyong Liang

8

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24 July 2017

Shiaw-Yih Lin

11

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24 July 2017

publication date

27 July 2006

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24 July 2017

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24 July 2017

volume

10

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24 July 2017

issue

2

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24 July 2017

page(s)

145-157

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Regulation of mitotic entry by microcephalin and its overlap with ATR signalling

24 July 2017

cites work

1 reference

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BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly

21 June 2018

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Genomic instability and cancer: networks involved in response to DNA damage

21 June 2018

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Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

21 June 2018

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

21 June 2018

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 June 2018

1 reference

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 June 2018

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 June 2018

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NFBD1/Mdc1 mediates ATR-dependent DNA damage response

21 June 2018

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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

21 June 2018

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Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression

21 June 2018

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Mechanisms leading to chromosomal instability.

21 June 2018

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Cell-cycle checkpoints and cancer

21 June 2018

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Replication protein A and gamma-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks

21 June 2018

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Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

21 June 2018

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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

21 June 2018

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Chk1 is haploinsufficient for multiple functions critical to tumor suppression

21 June 2018

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

21 June 2018

1 reference

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 June 2018

1 reference

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DNA damage tumor suppressor genes and genomic instability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Replication protein A-mediated recruitment and activation of Rad17 complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

The BRCT Domain Is a Phospho-Protein Binding Domain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

The MRN complex: coordinating and mediating the response to broken chromosomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

The role of DNA breaks in genomic instability and tumorigenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Multiple tumor suppressor pathways negatively regulate telomerase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Genomic instability and endoreduplication triggered by RAD17 deletion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Pathological and molecular aspects of prostate cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

MDC1 is a mediator of the mammalian DNA damage checkpoint

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

MDC1 is required for the intra-S-phase DNA damage checkpoint

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

ATR Regulates Fragile Site Stability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

The relationship between the roles of BRCA genes in DNA repair and cancer predisposition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Checking on the fork: the DNA-replication stress-response pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Toward maintaining the genome: DNA damage and replication checkpoints

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

53BP1, a mediator of the DNA damage checkpoint

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Invasive micropapillary carcinoma of the breast is associated with chromosome 8 abnormalities detected by comparative genomic hybridization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Interfaces between the detection, signaling, and repair of DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Identification of microcephalin, a protein implicated in determining the size of the human brain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Preferential binding of ATR protein to UV-damaged DNA.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Genomic instability in mice lacking histone H2AX

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Gene expression profiling predicts clinical outcome of breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

DNA damage by the enediyne C-1027 results in the inhibition of DNA replication by loss of replication protein A function and activation of DNA-dependent protein kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Assembly of microarrays for genome-wide measurement of DNA copy number

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

ATM and ATR: networking cellular responses to DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

The DNA damage response: putting checkpoints in perspective

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

High frequency of allelic imbalance at regions of chromosome arm 8p in ovarian carcinoma.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

High-density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1557410

Genome-wide allelotype analysis of sporadic primary nasopharyngeal carcinoma from southern China

31 October 2018

1 reference

12 December 2020

Comparison of serous and mucinous ovarian carcinomas: distinct pattern of allelic loss at distal 8p and expression of transcription factor GATA-4

1 reference

12 December 2020

Atm haploinsufficiency results in increased sensitivity to sublethal doses of ionizing radiation in mice

1 reference

12 December 2020

NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells

1 reference

12 December 2020

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

1 reference

12 December 2020

The cellular response to DNA double-strand breaks: defining the sensors and mediators

1 reference

12 December 2020

10.1016/J.CCR.2006.07.002

Identifiers

DOI

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24 July 2017

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24 July 2017

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