Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase (Q33519130)

27 July 2017

title

Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase (English)

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27 July 2017

6

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12

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Christopher P Austin

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27 July 2017

Craig J Thomas

14

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ORCID Public Data File 2021

Douglas S Auld

13

object named as

Douglas S Auld

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27 July 2017

2

Jian-kang Jiang

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27 July 2017

Matthew G Vander Heiden

3

object named as

Matthew G Vander Heiden

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27 July 2017

Amanda P Skoumbourdis

5

object named as

Amanda P Skoumbourdis

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27 July 2017

7

Henrike Veith

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27 July 2017

Matthew B Boxer

1

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27 July 2017

Min Shen

4

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27 July 2017

William Leister

8

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27 July 2017

Hee Won Park

10

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27 July 2017

James Inglese

11

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27 July 2017

language of work or name

English

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publication date

1 February 2010

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Journal of Medicinal Chemistry

27 July 2017

published in

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27 July 2017

volume

53

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27 July 2017

issue

3

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27 July 2017

page(s)

1048-1055

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Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening

27 July 2017

cites work

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 June 2018

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A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution

21 June 2018

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Brick by brick: metabolism and tumor cell growth

21 June 2018

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

21 June 2018

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

21 June 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 June 2018

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Bioluminescent assays for high-throughput screening

21 June 2018

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Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries

21 June 2018

1 reference

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Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis

21 June 2018

1 reference

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Pyruvate kinase type M2 and its role in tumor growth and spreading

21 June 2018

1 reference

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Nanoliter dispensing for uHTS using pin tools

21 June 2018

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Piezo- and solenoid valve-based liquid dispensing for miniaturized assays

21 June 2018

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NIH Molecular Libraries Initiative

21 June 2018

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On respiratory impairment in cancer cells

21 June 2018

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On the Origin of Cancer Cells

21 June 2018

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The putative effector-binding site of Leishmania mexicana pyruvate kinase studied by site-directed mutagenesis

21 June 2018

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Expression of pyruvate kinase M2 in preneoplastic hepatic foci of N-nitrosomorpholine-treated rats

21 June 2018

1 reference

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Regulation of pyruvate kinase M gene expression

21 June 2018

1 reference

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Alternative splicing of the pyruvate kinase M gene in a minigene system

21 June 2018

1 reference

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Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat

21 June 2018

1 reference

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The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters

21 June 2018

1 reference

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The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing

21 June 2018

1 reference

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Isolation and characterization of the human pyruvate kinase M gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818804

Identification of kinase inhibitors by an ATP depletion method

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818804

31 October 2018

Identifiers

DOI

10.1021/JM901577G

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27 July 2017

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27 July 2017

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