Regulation of Mdm2-directed degradation by the C terminus of p53. (Q33779929)

29 July 2017

title

Regulation of Mdm2-directed degradation by the C terminus of p53. (English)

1 reference

29 July 2017

M H Kubbutat

1

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29 July 2017

R L Ludwig

series ordinal

2

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29 July 2017

M Ashcroft

series ordinal

3

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29 July 2017

K H Vousden

series ordinal

4

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29 July 2017

language of work or name

English

0 references

publication date

1 October 1998

1 reference

Molecular and Cellular Biology

29 July 2017

published in

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29 July 2017

volume

18

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29 July 2017

issue

10

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29 July 2017

page(s)

5690-5698

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Regulation of p53 function and stability by phosphorylation

29 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

4 July 2018

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Activation of p53 DNA binding activity by point mutation

4 July 2018

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

4 July 2018

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

4 July 2018

1 reference

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

4 July 2018

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

4 July 2018

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Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

4 July 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

4 July 2018

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Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation

4 July 2018

1 reference

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p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

4 July 2018

1 reference

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

4 July 2018

1 reference

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Participation of the human p53 3'UTR in translational repression and activation following gamma-irradiation

4 July 2018

1 reference

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Regulation of p53 stability by Mdm2

4 July 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

4 July 2018

1 reference

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bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

4 July 2018

1 reference

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The p53-deficient mouse: a model for basic and applied cancer studies

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Activation of p53 transcriptional activity by 1,10-phenanthroline, a metal chelator and redox sensitive compound

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

p53 in signaling checkpoint arrest or apoptosis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Discordance between accumulated p53 protein level and its transcriptional activity in response to u.v. radiation.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

4 July 2018

p53: puzzle and paradigm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Cell type-specific inhibition of p53-mediated apoptosis by mdm2.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

mdm2 expression is induced by wild type p53 activity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

The p53-mdm-2 autoregulatory feedback loop

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Oligomerisation of full length p53 contributes to the interaction with mdm2 but not HPV E6.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Mapping of the p53 and mdm-2 Interaction Domains

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein Kinases

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

p21 is necessary for the p53-mediated G1 arrest in human cancer cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Radiation-induced cell cycle arrest compromised by p21 deficiency

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Participation of p53 protein in the cellular response to DNA damage

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Cancer. p53, guardian of the genome

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

p53 function and dysfunction

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Regulation of the specific DNA binding function of p53

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Induction of apoptosis in HeLa cells by trans-activation-deficient p53

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Small peptides activate the latent sequence-specific DNA binding function of p53.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

High-frequency developmental abnormalities in p53-deficient mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109155

Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53

30 October 2018

1 reference

12 December 2020

The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain

1 reference

12 December 2020

Sensitivity of p53 lysine mutants to ubiquitin-directed degradation targeted by human papillomavirus E6

1 reference

12 December 2020

In vivo ubiquitination and proteasome-mediated degradation of p53(1)

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.18.10.5690

1 reference

29 July 2017

1 reference

29 July 2017

1 reference