Is TP53 dysfunction required for BRCA1-associated carcinogenesis? (Q33784155)

29 July 2017

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title

Is TP53 dysfunction required for BRCA1-associated carcinogenesis? (English)

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29 July 2017

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Schuyer M

1

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29 July 2017

Berns EM

series ordinal

2

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29 July 2017

publication date

1 September 1999

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Molecular and Cellular Endocrinology

29 July 2017

published in

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29 July 2017

volume

155

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29 July 2017

issue

1-2

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29 July 2017

page(s)

143-152

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Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation

29 July 2017

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The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter

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Transcriptional activation by BRCA1

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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

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p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

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Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination

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BRCA1 as a potential human prostate tumor suppressor: modulation of proliferation, damage responses and expression of cell regulatory proteins

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Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype–phenotype correlation

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Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

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BRCA1 required for transcription-coupled repair of oxidative DNA damage

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The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

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Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

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A somatic BRCA1 mutation in an ovarian tumour

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7 January 2021

Histoprognostic grade in BRCA1-associated breast cancer

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7 January 2021

BRCA1 is secreted and exhibits properties of a granin

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7 January 2021

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

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7 January 2021

Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains

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7 January 2021

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7 January 2021

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7 January 2021

Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage

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A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

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7 January 2021

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

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7 January 2021

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

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7 January 2021

Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage

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7 January 2021

BRCA1 expression is not directly responsive to estrogen

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7 January 2021

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

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7 January 2021

Inactivation of p53 results in high rates of homologous recombination

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7 January 2021

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.

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7 January 2021

Evidence for a transcriptional activation function of BRCA1 C-terminal region

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7 January 2021

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

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7 January 2021

Detailed deletion mapping of chromosome segment 17q12-21 in sporadic breast tumours

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7 January 2021

Preferential allelic expression can lead to reduced expression of BRCA1 in sporadic breast cancers

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7 January 2021

BRCA1 regulates p53-dependent gene expression

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7 January 2021

Frequency of p53 mutations in breast carcinomas from Ashkenazi Jewish carriers of BRCA1 mutations

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7 January 2021

Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells

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7 January 2021

BRCA-associated breast cancer in young women

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7 January 2021

Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations ofBRCA1

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7 January 2021

Identification of allelic losses in benign, borderline, and invasive epithelial ovarian tumors and correlation with clinical outcome

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7 January 2021

Does this have a familiar RING?

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7 January 2021

Loss of heterozygosity on chromosome 17q11-21 in cancers of women who have both breast and ovarian cancer

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

p53 mutations in BRCA1-associated familial breast cancer

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

High prevalence of codon 213Arg-->Stop mutations of the TP53 gene in human ovarian cancer in the southwestern part of The Netherlands

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Location of BRCA1 in human breast and ovarian cancer cells

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

BRCA1 is a component of the RNA polymerase II holoenzyme

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Association of BRCA1 with Rad51 in mitotic and meiotic cells

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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7 January 2021

A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening

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7 January 2021

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Genetic aberrations in hypodiploid breast cancer: frequent loss of chromosome 4 and amplification of cyclin D1 oncogene

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Localization of BRCA1 and a splice variant identifies the nuclear localization signal

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Survival and tumour characteristics of breast-cancer patients with germline mutations of BRCA1.

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Characterization of a carboxy-terminal BRCA1 interacting protein

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

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https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

BRCA1 physically associates with p53 and stimulates its transcriptional activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0303-7207%2899%2900117-3

7 January 2021

10.1016/S0303-7207(99)00117-3

Identifiers

DOI

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29 July 2017

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