Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice (Q33849632)

29 July 2017

title

Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice (English)

1 reference

29 July 2017

A Amrani

1

1 reference

29 July 2017

J Verdaguer

2

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29 July 2017

B Anderson

3

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29 July 2017

T Utsugi

4

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29 July 2017

S Bou

5

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29 July 2017

P Santamaria

6

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29 July 2017

language of work or name

English

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publication date

1 April 1999

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Journal of Clinical Investigation

29 July 2017

published in

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29 July 2017

volume

103

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29 July 2017

issue

8

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29 July 2017

page(s)

1201-1209

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Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement

29 July 2017

cites work

1 reference

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The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) mice

5 July 2018

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The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD.

5 July 2018

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Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice

5 July 2018

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Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice

5 July 2018

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Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice

5 July 2018

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Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus

5 July 2018

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Mouse islet cell lysis mediated by interleukin-1-induced Fas.

5 July 2018

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Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains

5 July 2018

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Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity

5 July 2018

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CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

5 July 2018

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

5 July 2018

1 reference

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A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity

5 July 2018

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Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.

5 July 2018

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Genetic and pathogenic basis of autoimmune diabetes in NOD mice

5 July 2018

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Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

5 July 2018

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Genetic control of autoimmune diabetes in the NOD mouse

5 July 2018

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Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice

5 July 2018

1 reference

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5 July 2018

The CTL's kiss of death

1 reference

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Immune function in mice lacking the perforin gene

5 July 2018

1 reference

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Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

5 July 2018

1 reference

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Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408282

Partial activation of CD8+ T cells by a self-derived peptide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408282

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408282

Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408282

Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408282

T cell receptor V gene usage of islet beta cell-reactive T cells is not restricted in non-obese diabetic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408282

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408282

Genetic absence of gamma-interferon delays but does not prevent diabetes in NOD mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408282

Analysis of the roles of CD4+ and CD8+ T cells in autoimmune diabetes of NOD mice using transfer to NOD athymic nude mice.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=408282

An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes

29 October 2018

1 reference

12 December 2020

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice

1 reference

12 December 2020

CD8 T cells are not required for islet destruction induced by a CD4+ islet-specific T-cell clone

1 reference

12 December 2020

Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors

1 reference

12 December 2020

Identification and quantification of a naturally presented peptide as recognized by cytotoxic T lymphocytes specific for an immunogenic tumor variant

1 reference

12 December 2020

Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice

1 reference

12 December 2020

Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes

1 reference

12 December 2020

Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant

1 reference

12 December 2020

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1 reference

12 December 2020

T helper cell subsets in insulin-dependent diabetes

1 reference

12 December 2020

Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro

1 reference

12 December 2020

Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones. Differential requirement for CD8 T-cells

1 reference

12 December 2020

Insulin-dependent diabetes mellitus

1 reference

12 December 2020

The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus

1 reference

12 December 2020

RIP-beta 2-microglobulin transgene expression restores insulitis, but not diabetes, in beta 2-microglobulin null nonobese diabetic mice

1 reference

12 December 2020

The role of Fas in autoimmune diabetes

1 reference

12 December 2020

Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI6266

1 reference

29 July 2017

1 reference

29 July 2017

1 reference