Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2. (Q33928616)

30 July 2017

title

Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2. (English)

1 reference

30 July 2017

4

Alan R Fersht

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30 July 2017

author name string

Sridharan Rajagopalan

series ordinal

1

1 reference

30 July 2017

Antonina Andreeva

series ordinal

2

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30 July 2017

Trevor J Rutherford

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

26 April 2010

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

volume

107

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30 July 2017

issue

19

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30 July 2017

page(s)

8587-8592

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The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange

30 July 2017

cites work

1 reference

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14-3-3 activation of DNA binding of p53 by enhancing its association into tetramers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Structural biology of the tumor suppressor p53.

5 July 2018

1 reference

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P53 promoter selection: choosing between life and death

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

BRCA2: a universal recombinase regulator.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

p53 in recombination and repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

p53: traffic cop at the crossroads of DNA repair and recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

The interaction of p53 with replication protein A mediates suppression of homologous recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2.

5 July 2018

1 reference

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p53's double life: transactivation-independent repression of homologous recombination.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

DNA substrate dependence of p53-mediated regulation of double-strand break repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Live or let die: the cell's response to p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

5 July 2018

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5 July 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Homologous and nonhomologous recombination resulting in deletion: effects of p53 status, microhomology, and repetitive DNA length and orientation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Cancer risks in BRCA2 mutation carriers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

The BRCA2 gene product functionally interacts with p53 and RAD51

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Involvement of Brca2 in DNA repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Interaction of p53 with the human Rad51 protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Brca2 is required for embryonic cellular proliferation in the mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Inactivation of p53 results in high rates of homologous recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

p53, the cellular gatekeeper for growth and division

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1003689107

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1003689107

Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1003689107

A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1003689107

Loss of Brca2 and p53 synergistically promotes genomic instability and deregulation of T-cell apoptosis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Germline mutations in BRCA1 and BRCA2 in breast-ovarian families from a breast cancer risk evaluation clinic

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2889359

Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

29 October 2018

1 reference

12 December 2020

BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability

1 reference

12 December 2020

Increased frequency ofTP53 mutations inBRCA1 andBRCA2 ovarian tumours

1 reference

12 December 2020

Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53

1 reference

12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1003689107

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference