Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. (Q44286601)

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17 December 2019

title

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders (English)

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17 December 2019

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1

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17 December 2019

author name string

Christian Mahlke

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Junying Yuan

series ordinal

3

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17 December 2019

language of work or name

English

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publication date

1 January 2003

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17 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

volume

421

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17 December 2019

issue

6921

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17 December 2019

page(s)

373-379

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

17 December 2019

cites work

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Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

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Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

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Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

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Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

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Polar zippers: their role in human disease

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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7 January 2021

Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation

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A model for structure-dependent binding of Congo red to Alzheimer beta-amyloid fibrils.

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Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy

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Chrysamine-G binding to Alzheimer and control brain: autopsy study of a new amyloid probe

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Caspase-8 is required for cell death induced by expanded polyglutamine repeats.

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Do defecs in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

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Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

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Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.

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7 January 2021

Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

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7 January 2021

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

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7 January 2021

Genetic suppression of polyglutamine toxicity in Drosophila

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7 January 2021

Formic acid dissolves aggregates of an N-terminal huntingtin fragment containing an expanded polyglutamine tract: applying to quantification of protein components of the aggregates

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7 January 2021

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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7 January 2021

Impairment of the ubiquitin-proteasome system by protein aggregation

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7 January 2021

Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

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7 January 2021

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

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7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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7 January 2021

Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells

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7 January 2021

Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.

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7 January 2021

Identifiers

DOI

10.1038/NATURE01301

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12540902%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 December 2019

1017653700

0 references

1 reference