Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo (Q46189582)

20 December 2017

title

Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo (English)

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20 December 2017

Tobias B Dansen

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Jonathan Whitfield

object named as

Jonathan Whitfield

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author name string

Fanya Rostker

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20 December 2017

Lamorna Brown-Swigart

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20 December 2017

Gerard I Evan

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20 December 2017

language of work or name

English

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publication date

7 February 2006

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20 December 2017

Journal of Biological Chemistry

published in

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20 December 2017

volume

281

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20 December 2017

issue

16

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20 December 2017

page(s)

10890-10895

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20 December 2017

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

c-Myc target genes involved in cell growth, apoptosis, and metabolism

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

c-MYC: more than just a matter of life and death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

Myc potentiates apoptosis by stimulating Bax activity at the mitochondria

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

MYC oncogenes and human neoplastic disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513655200

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513655200

c-Myc functionally cooperates with Bax to induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513655200

Bim is a suppressor of Myc-induced mouse B cell leukemia

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513655200

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513655200

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513655200

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M513655200

Intrinsic tumour suppression

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M513655200

21 January 2018

Identifiers

DOI

10.1074/JBC.M513655200

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20 December 2017

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20 December 2017