Antioxidants N-acetyl-L-cysteine and manganese(III)tetrakis (4-benzoic acid)porphyrin do not prevent beta-cell dysfunction in rat islets cultured in high glucose for 1 wk. (Q46933169)

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scientific article published on 7 February 2006

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English	Antioxidants N-acetyl-L-cysteine and manganese(III)tetrakis (4-benzoic acid)porphyrin do not prevent beta-cell dysfunction in rat islets cultured in high glucose for 1 wk.	scientific article published on 7 February 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16464909

Antioxidants N-acetyl-L-cysteine and manganese(III)tetrakis (4-benzoic acid)porphyrin do not prevent beta-cell dysfunction in rat islets cultured in high glucose for 1 wk. (English)

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Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16464909

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Jean-Christophe Jonas

5

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Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16464909

author name string

M Z Khaldi

1

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26 December 2017

http://europepmc.org/abstract/MED/16464909

H Elouil

2

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26 December 2017

http://europepmc.org/abstract/MED/16464909

Y Guiot

3

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26 December 2017

http://europepmc.org/abstract/MED/16464909

J C Henquin

4

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26 December 2017

http://europepmc.org/abstract/MED/16464909

publication date

7 February 2006

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26 December 2017

http://europepmc.org/abstract/MED/16464909

American Journal of Physiology - Endocrinology and Metabolism

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26 December 2017

http://europepmc.org/abstract/MED/16464909

291

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http://europepmc.org/abstract/MED/16464909

1

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26 December 2017

http://europepmc.org/abstract/MED/16464909

E137-46

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Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16464909

Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets

1 reference

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Visualizing superoxide production in normal and diabetic rat islets of Langerhans

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Biochemistry and molecular cell biology of diabetic complications

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A radical explanation for glucose-induced beta cell dysfunction

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

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High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB.

1 reference

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Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

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Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?

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Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes

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Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines.

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Determination of total serum insulin (IRI) in insulin-treated diabetic patients

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Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

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Antioxidant alpha-tocopherol ameliorates glycemic control of GK rats, a model of type 2 diabetes.

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Haeme-oxygenase 1 expression in rat pancreatic beta cells is stimulated by supraphysiological glucose concentrations and by cyclic AMP.

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21 January 2018

Glucotoxicity and beta-cell failure in type 2 diabetes mellitus

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Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00145.2005

21 January 2018

Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00145.2005

21 January 2018

Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose

1 reference

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21 January 2018

Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes

1 reference

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21 January 2018

Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment.

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21 January 2018

Protein kinase C activation and the development of diabetic complications

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A simple, rapid, and sensitive DNA assay procedure

1 reference

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21 January 2018

Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00145.2005

21 January 2018

Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00145.2005

21 January 2018

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00145.2005

21 January 2018

Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells

1 reference

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21 January 2018

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

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21 January 2018

Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion

1 reference

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21 January 2018

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00145.2005

21 January 2018

Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress.

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00145.2005

21 January 2018

Evidence that increased 12-lipoxygenase expression impairs pancreatic beta cell function and viability

1 reference

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21 January 2018

Dose-dependent cysteine-mediated protection of insulin-producing cells from damage by hydrogen peroxide

1 reference

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21 January 2018

Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

1 reference

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21 January 2018

Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection

1 reference

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21 January 2018

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00145.2005

21 January 2018

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

1 reference

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21 January 2018

Vascular targets of redox signalling in diabetes mellitus

1 reference

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D-Glyceraldehyde causes production of intracellular peroxide in pancreatic islets, oxidative stress, and defective beta cell function via non-mitochondrial pathways

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00145.2005

21 January 2018

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

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A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

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Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

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Mitogen-activated protein kinases as glucose transducers for diabetic complications

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The U.K. Prospective Diabetes Study. A review.

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Astaxanthin protects beta-cells against glucose toxicity in diabetic db/db mice

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Oxidative stress in the pathogenesis of diabetic neuropathy

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Beta-cell adaptation and decompensation during the progression of diabetes.

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Oxidative stress as a therapeutic target in diabetes: revisiting the controversy

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Identifiers

10.1152/AJPENDO.00145.2005

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16464909

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 December 2017

http://europepmc.org/abstract/MED/16464909

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