Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway (Q48022280)

7 February 2018

title

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway (English)

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7 February 2018

author

Albert J Fornace

8

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author name string

Dmitry V Bulavin

1

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Crissy Phillips

2

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Bonnie Nannenga

3

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Oleg Timofeev

4

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Larry A Donehower

5

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Carl W Anderson

6

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Ettore Appella

7

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language of work or name

English

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publication date

29 February 2004

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7 February 2018

published in

Nature Genetics

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volume

36

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issue

4

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page(s)

343-350

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7 February 2018

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

cites work

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 January 2018

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Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

21 January 2018

1 reference

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

21 January 2018

1 reference

Osmotic stress regulates the stability of cyclin D1 in a p38SAPK2-dependent manner

21 January 2018

1 reference

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

21 January 2018

1 reference

Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint

21 January 2018

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

21 January 2018

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

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Mechanism of p38 MAP kinase activation in vivo.

21 January 2018

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Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

21 January 2018

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Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

21 January 2018

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Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

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Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

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Suppression of Neu-induced mammary tumor growth in cyclin D1 deficient mice is compensated for by cyclin E.

21 January 2018

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Specific protection against breast cancers by cyclin D1 ablation

21 January 2018

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p16(MTS-1/CDKN2/INK4a) in cancer progression

21 January 2018

1 reference

p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials

21 January 2018

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The structure and expression of the murine wildtype p53-induced phosphatase 1 (Wip1) gene

21 January 2018

1 reference

Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer

21 January 2018

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Genetic alterations in breast cancer.

21 January 2018

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p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony

21 January 2018

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Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

21 January 2018

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Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

21 January 2018

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Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

21 January 2018

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Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

21 January 2018

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p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB.

21 January 2018

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

21 January 2018

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Cyclin D1 protein expression and function in human breast cancer

21 January 2018

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Methylation of the p16(Ink4a) tumor suppressor gene 5'-CpG island in breast cancer

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Deregulation of p53/p21Cip1/Waf1 pathway contributes to polyploidy and apoptosis of E1A+cHa-ras transformed cells after gamma-irradiation

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Estimation of relative mRNA content by filter hybridization to a polyuridylic probe

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NG1317

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7 February 2018

Dimensions Publication ID

1037400245

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Fatcat ID

release_qwg65e4hqjfvphlycwvkzq2zlu

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7 February 2018