Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity. (Q40515168)

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1 January 2020

title

Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15371500%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

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Ali Khoshnan

1

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1 January 2020

Jan Ko

2

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1 January 2020

Erin E Watkin

3

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1 January 2020

Lisa A Paige

4

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1 January 2020

Peter H Reinhart

5

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1 January 2020

Paul H Patterson

6

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1 January 2020

language of work or name

English

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publication date

1 September 2004

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1 January 2020

published in

Journal of Neuroscience

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1 January 2020

volume

24

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1 January 2020

issue

37

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1 January 2020

page(s)

7999-8008

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Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum

1 January 2020

cites work

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12 December 2020

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1 reference

12 December 2020

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

1 reference

12 December 2020

Cellular survival: a play in three Akts

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12 December 2020

Activators and target genes of Rel/NF-kappaB transcription factors

1 reference

12 December 2020

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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12 December 2020

Glutamine repeats and neurodegeneration

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12 December 2020

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

1 reference

12 December 2020

Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis

1 reference

12 December 2020

The early cellular pathology of Huntington's disease

1 reference

12 December 2020

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

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12 December 2020

Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization

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12 December 2020

NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells.

1 reference

12 December 2020

Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations

1 reference

12 December 2020

Huntington's disease: the challenge for cell biologists

1 reference

12 December 2020

FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis

1 reference

12 December 2020

Neurological abnormalities in a knock-in mouse model of Huntington's disease

1 reference

12 December 2020

NF-kappaB in neuronal plasticity and neurodegenerative disorders

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12 December 2020

Loss of normal huntingtin function: new developments in Huntington's disease research

1 reference

12 December 2020

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

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12 December 2020

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

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12 December 2020

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

1 reference

12 December 2020

New anti-huntingtin monoclonal antibodies: implications for huntingtin conformation and its binding proteins

1 reference

12 December 2020

Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity

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12 December 2020

Differential sensitivity of medium- and large-sized striatal neurons to NMDA but not kainate receptor activation in the rat.

1 reference

12 December 2020

NF-kappaB at the crossroads of life and death

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12 December 2020

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

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12 December 2020

The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

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12 December 2020

Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice

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12 December 2020

Missing pieces in the NF-kappaB puzzle

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12 December 2020

Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100

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12 December 2020

Akt is a downstream target of NF-kappa B.

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12 December 2020

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

1 reference

12 December 2020

Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

1 reference

12 December 2020

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

1 reference

12 December 2020

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

1 reference

12 December 2020

Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function

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12 December 2020

IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.

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12 December 2020

Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation

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12 December 2020

From calcium to NF-kappa B signaling pathways in neurons

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12 December 2020

Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

1 reference

12 December 2020

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

1 reference

12 December 2020

Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

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12 December 2020

A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

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12 December 2020

Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation

1 reference

12 December 2020

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

1 reference

12 December 2020

Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases

1 reference

12 December 2020

Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells

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12 December 2020

Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression

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12 December 2020

Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis

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12 December 2020

CRE-mediated transcription is increased in Huntington's disease transgenic mice.

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12 December 2020

Neuronal transfection in brain slices using particle-mediated gene transfer.

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12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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12 December 2020

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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12 December 2020

Huntingtin interacts with a family of WW domain proteins

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12 December 2020

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

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12 December 2020

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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12 December 2020

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

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12 December 2020

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

1 reference

12 December 2020

10.1523/JNEUROSCI.2675-04.2004

Identifiers

DOI

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1 January 2020

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1 January 2020

PubMed publication ID

15371500

1 reference