Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons (Q40564428)

21 September 2017

title

Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons (English)

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Membrane metalloendopeptidase

21 September 2017

main subject

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amyloid-beta clearance by cellular catabolic process

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

Emi Hama

1

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21 September 2017

Keiro Shirotani

2

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21 September 2017

Nobuhisa Iwata

3

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21 September 2017

Takaomi C Saido

4

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21 September 2017

language of work or name

English

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publication date

20 April 2004

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Journal of Biological Chemistry

21 September 2017

published in

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21 September 2017

volume

279

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21 September 2017

issue

29

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21 September 2017

page(s)

30259-30264

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Amyloid, the presenilins and Alzheimer's disease

21 September 2017

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21 January 2018

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21 January 2018

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21 January 2018

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Clearance of extracellular and cell-associated amyloid beta peptide through viral expression of neprilysin in primary neurons

21 January 2018

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Endoplasmic reticulum localization of Sec12p is achieved by two mechanisms: Rer1p-dependent retrieval that requires the transmembrane domain and Rer1p-independent retention that involves the cytoplasmic domain.

21 January 2018

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21 January 2018

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21 January 2018

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Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

21 January 2018

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Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M401891200

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21 September 2017

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