Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation (Q40587895)

21 September 2017

title

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation (English)

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21 September 2017

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2

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21 September 2017

Alessandra Fragale

1

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Bruce D. Gelb

series ordinal

4

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author name string

Jie Wu

series ordinal

3

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21 September 2017

publication date

1 March 2004

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21 September 2017

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21 September 2017

volume

23

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21 September 2017

issue

3

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21 September 2017

page(s)

267-277

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Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

21 September 2017

cites work

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Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase

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Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.

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Gab1 and SHP-2 promote Ras/MAPK regulation of epidermal growth and differentiation

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A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis

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Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

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Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor

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7 January 2021

Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

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Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

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Shp-2 tyrosine phosphatase: signaling one cell or many

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SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

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Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew

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Crystal structure of the tyrosine phosphatase SHP-2

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7 January 2021

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Mapping a gene for Noonan syndrome to the long arm of chromosome 12

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Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts

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7 January 2021

PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome

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7 January 2021

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7 January 2021

PTPN11 mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13.

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Congenital heart diseases in children with Noonan syndrome: An expanded cardiac spectrum with high prevalence of atrioventricular canal

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7 January 2021

The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase

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7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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7 January 2021

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

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7 January 2021

Non-radioactive method to measure CD45 protein tyrosine phosphatase activity isolated directly from cells

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7 January 2021

Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

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7 January 2021

Phosphorylated synthetic peptides as tools for studying protein phosphatases

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7 January 2021

Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development

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7 January 2021

The phosphotyrosine phosphatase PTP1D, but not PTP1C, is an essential mediator of fibroblast proliferation induced by tyrosine kinase and G protein-coupled receptors

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7 January 2021

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

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7 January 2021

Mutagenesis reveals a role for epidermal growth factor receptor extracellular subdomain IV in ligand binding

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7 January 2021

The SH2 tyrosine phosphatase shp2 is required for mammalian limb development.

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7 January 2021

PTPN11 mutation in a large family with Noonan syndrome and dizygous twinning

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7 January 2021

The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases

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7 January 2021

Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

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7 January 2021

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development

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7 January 2021

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

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7 January 2021

PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity

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7 January 2021

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

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7 January 2021

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1 reference

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7 January 2021

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

1 reference

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7 January 2021

Altered expression of protein-tyrosine phosphatase 2C in 293 cells affects protein tyrosine phosphorylation and mitogen-activated protein kinase activation

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7 January 2021

Identifiers

DOI

10.1002/HUMU.20005

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21 September 2017

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