Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). (Q40654202)

22 September 2017

title

Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). (English)

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22 September 2017

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multiple drug resistance

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3

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22 September 2017

8

Jan H M Schellens

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22 September 2017

Noam Zelcer

1

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22 September 2017

Maarten T Huisman

2

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22 September 2017

Peter Wielinga

4

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22 September 2017

Pauline Breedveld

5

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22 September 2017

Annemieke Kuil

6

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22 September 2017

Puck Knipscheer

7

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22 September 2017

Alfred H Schinkel

9

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22 September 2017

Piet Borst

10

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22 September 2017

language of work or name

English

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publication date

17 April 2003

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Journal of Biological Chemistry

22 September 2017

published in

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22 September 2017

volume

278

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22 September 2017

issue

26

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22 September 2017

page(s)

23538-23544

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Mammalian ABC transporters in health and disease

22 September 2017

cites work

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Transport of leukotriene C4 and structurally related conjugates

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Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters.

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Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

21 January 2018

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Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

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Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

21 January 2018

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Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein

21 January 2018

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Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

21 January 2018

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Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export

21 January 2018

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Transport of the beta -O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1). Requirement for glutathione or a non-sulfur-containing analog

21 January 2018

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Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs

21 January 2018

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Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

21 January 2018

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Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).

21 January 2018

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Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport

21 January 2018

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Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump

21 January 2018

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Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats.

21 January 2018

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ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids

21 January 2018

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Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter

21 January 2018

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Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.

21 January 2018

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Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2.

21 January 2018

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Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport

21 January 2018

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

21 January 2018

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Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).

21 January 2018

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Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport

21 January 2018

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Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1.

21 January 2018

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Structure-activity studies of verapamil analogs that modulate transport of leukotriene C(4) and reduced glutathione by multidrug resistance protein MRP1.

21 January 2018

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Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

21 January 2018

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Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity

21 January 2018

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Solute modulation of conformational equilibria in intrinsic membrane proteins: apparent "cooperativity" without binding

21 January 2018

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Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).

21 January 2018

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Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells

21 January 2018

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Differential Modulation of the Human Liver Conjugate Transporters MRP2 and MRP3 by Bile Acids and Organic Anions

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M303504200

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release_5v35d2eid5fn5aow3jx7wcw63i

22 September 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5v35d2eid5fn5aow3jx7wcw63i

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference