Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function. (Q40658225)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12676955%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

title

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function (English)

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2 November 2019

1

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2 November 2019

Nitish Thakor

series ordinal

3

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2 November 2019

author name string

Paul S Fishman

series ordinal

2

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2 November 2019

George A Oyler

series ordinal

4

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2 November 2019

language of work or name

English

0 references

publication date

3 April 2003

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Journal of Biological Chemistry

2 November 2019

number of pages

12

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based on heuristic

inferred from page(s)

published in

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2 November 2019

volume

278

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2 November 2019

issue

24

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2 November 2019

page(s)

22044-22055

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

2 November 2019

cites work

1 reference

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

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Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

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Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate

21 January 2018

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Dissociation from BiP and retrotranslocation of unassembled immunoglobulin light chains are tightly coupled to proteasome activity

21 January 2018

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Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

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Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

21 January 2018

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Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation

21 January 2018

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CREB-binding protein sequestration by expanded polyglutamine

21 January 2018

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Poly-L-glutamine forms cation channels: relevance to the pathogenesis of the polyglutamine diseases

21 January 2018

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Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

21 January 2018

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Proteasomal function is impaired in substantia nigra in Parkinson's disease

21 January 2018

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

21 January 2018

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

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Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

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Identification of genes that modify ataxin-1-induced neurodegeneration.

21 January 2018

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Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

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Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in Drosophila

21 January 2018

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Genetic suppression of polyglutamine toxicity in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M212235200

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Proteasome subunit Rpn1 binds ubiquitin-like protein domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Identification of ubiquitin-like protein-binding subunits of the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Multiple associated proteins regulate proteasome structure and function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M212235200

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

21 January 2018

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Alpha-synuclein and neurodegenerative diseases

21 January 2018

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Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M212235200

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

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Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

21 January 2018

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Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila

21 January 2018

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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

21 January 2018

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Rad23 provides a link between the Png1 deglycosylating enzyme and the 26 S proteasome in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Physical association of ubiquitin ligases and the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Caspase-12 processing and fragment translocation into nuclei of tunicamycin-treated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Pathologic and biochemical studies of juvenile parkinsonism linked to chromosome 6q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Familial juvenile parkinsonism: clinical and pathologic study in a family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Lewy bodies and parkinsonism in families with parkin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212235200

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M212235200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12676955%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

1 reference