Immortalization and transformation of primary human airway epithelial cells by gene transfer. (Q40722115)

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10 November 2019

title

Immortalization and transformation of primary human airway epithelial cells by gene transfer (English)

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10 November 2019

7

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William C Hahn

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10 November 2019

author name string

Ante S Lundberg

1

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10 November 2019

Scott H Randell

2

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10 November 2019

Sheila A Stewart

3

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10 November 2019

Brian Elenbaas

4

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10 November 2019

Kimberly A Hartwell

5

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10 November 2019

Mary W Brooks

6

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10 November 2019

John C Olsen

8

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10 November 2019

Scott W Miller

9

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10 November 2019

Robert A Weinberg

10

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10 November 2019

language of work or name

English

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publication date

1 July 2002

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10 November 2019

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10 November 2019

volume

21

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10 November 2019

issue

29

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10 November 2019

page(s)

4577-4586

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Extension of life-span by introduction of telomerase into normal human cells

10 November 2019

cites work

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Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

21 January 2018

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

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Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation

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Predisposition to neoplastic transformation caused by gene replacement of H-ras1.

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Creation of human tumour cells with defined genetic elements

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Enumeration of the simian virus 40 early region elements necessary for human cell transformation

21 January 2018

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Telomerase activity is sufficient to allow transformed cells to escape from crisis

21 January 2018

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Transfection of the EJ rasHa gene into keratinocytes derived from carcinogen-induced mouse papillomas causes malignant progression

21 January 2018

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The serial cultivation of human diploid cell strains

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Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

21 January 2018

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

21 January 2018

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Expression and localization of epithelial aquaporins in the adult human lung

21 January 2018

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Clonal growth of normal adult human bronchial epithelial cells in a serum-free medium.

21 January 2018

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Crisis intervention: the role of telomerase

21 January 2018

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Human Colon Carcinoma Ki-ras2 Oncogene and Its Corresponding Proto-Oncogene

21 January 2018

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Cell number and distribution in human and rat airways

21 January 2018

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A series of mammalian expression vectors and characterisation of their expression of a reporter gene in stably and transiently transfected cells

21 January 2018

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Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

21 January 2018

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Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

21 January 2018

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Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses

21 January 2018

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Senescence as a mode of tumor suppression

21 January 2018

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Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells

21 January 2018

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Cellular senescence: mitotic clock or culture shock?

21 January 2018

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Expression of SV40 large T antigen, but not small t antigen, is required for the induction of chromosomal aberrations in transformed human cells

21 January 2018

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Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase.

21 January 2018

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Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures

21 January 2018

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The two-stage mechanism controlling cellular senescence and immortalization

21 January 2018

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Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene.

21 January 2018

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Critical role for SV40 small-t antigen in human cell transformation

21 January 2018

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Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

21 January 2018

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Mucin gene expression during differentiation of human airway epithelia in vitro. Muc4 and muc5b are strongly induced

21 January 2018

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7 January 2021

Increased expression of mutated Ha-ras during premalignant progression in SENCAR mouse skin

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7 January 2021

Chapter 2 Identification and Culture of Human Bronchial Epithelial Cells

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7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205550

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12085236%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 November 2019

1036778178

0 references

1 reference