Huntington disease: new insights into the relationship between CAG expansion and disease (Q41170305)

27 September 2017

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title

Huntington disease: new insights into the relationship between CAG expansion and disease (English)

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27 September 2017

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Nasir J

1

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27 September 2017

Goldberg YP

series ordinal

2

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27 September 2017

Hayden MR

series ordinal

3

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27 September 2017

publication date

1 January 1996

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27 September 2017

published in

Human Molecular Genetics

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27 September 2017

volume

5 Spec No

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27 September 2017

page(s)

1431-1435

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

27 September 2017

cites work

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Widespread expression of Huntington's disease gene (IT15) protein product

21 January 2018

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Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

21 January 2018

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Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

21 January 2018

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Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

21 January 2018

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Evidence from antibody studies that the CAG repeat in the Huntington disease gene is expressed in the protein

21 January 2018

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A huntingtin-associated protein enriched in brain with implications for pathology

21 January 2018

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Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH.

21 January 2018

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Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript

21 January 2018

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Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

21 January 2018

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SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

21 January 2018

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

21 January 2018

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Inactivation of the mouse Huntington's disease gene homolog Hdh

21 January 2018

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Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

21 January 2018

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Homozygotes for Huntington's disease

21 January 2018

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Meiotic stability and genotype-phenotype correlation of the trinucleotide repeat in X-linked spinal and bulbar muscular atrophy

21 January 2018

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DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

21 January 2018

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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

21 January 2018

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

21 January 2018

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Transcriptional activation modulated by homopolymeric glutamine and proline stretches

21 January 2018

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Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase

21 January 2018

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The combined use of positron emission tomography and DNA polymorphisms for preclinical detection of Huntington's disease

21 January 2018

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Serial changes of cerebral glucose metabolism and caudate size in persons at risk for Huntington's disease.

21 January 2018

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Rat brain glyceraldehyde-3-phosphate dehydrogenase interacts with the recombinant cytoplasmic domain of Alzheimer's beta-amyloid precursor protein

21 January 2018

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Ubiquitin-reactive neurites in cerebral cortex of subjects with Huntington's chorea: a pathological correlate of dementia?

21 January 2018

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Cerebral soluble ubiquitin is increased in patients with Alzheimer's disease

21 January 2018

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Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin

21 January 2018

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The cytomegalovirus enhancer: a pan-active control element in transgenic mice

21 January 2018

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5′‐flanking sequences of the human HPRT gene direct neuronal expression in the brain of transgenic mice

21 January 2018

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Tissue- and site-specific DNA recombination in transgenic mice

21 January 2018

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10.1093/HMG/5.SUPPLEMENT_1.1431

21 January 2018

Identifiers

DOI

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27 September 2017

1 reference