Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice. (Q54037114)

24 May 2018

title

Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice. (English)

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24 May 2018

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Flechsig E

1

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24 May 2018

Shmerling D

2

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24 May 2018

Hegyi I

3

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24 May 2018

Raeber AJ

4

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24 May 2018

Fischer M

5

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24 May 2018

Cozzio A

6

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24 May 2018

von Mering C

7

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24 May 2018

Aguzzi A

8

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24 May 2018

Weissmann C

9

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24 May 2018

language of work or name

English

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publication date

1 August 2000

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24 May 2018

published in

Neuron

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24 May 2018

volume

27

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24 May 2018

issue

2

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24 May 2018

page(s)

399-408

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24 May 2018

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

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Normal host prion protein necessary for scrapie-induced neurotoxicity

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Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

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Mice devoid of PrP are resistant to scrapie

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High prion and PrPSc levels but delayed onset of disease in scrapie-inoculated mice heterozygous for a disrupted PrP gene

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Encephalopathy in mice produced by inoculation with scrapie brain material

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Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

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Transmission of fatal familial insomnia to laboratory animals

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Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

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Self-replication and scrapie

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7 January 2021

Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein.

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Linkage of a prion protein missense variant to Gerstmann-Sträussler syndrome

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Pathogenesis of scrapie is faster when infection is intraspinal instead of intracerebral

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Temporary and permanent modifications to a single strain of mouse scrapie on transmission to rats and hamsters

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Prion (PrPSc)-specific epitope defined by a monoclonal antibody

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Prion disease associated with a novel nine octapeptide repeat insertion in the PRNP gene.

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Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

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A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy

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Evolution of a strain of CJD that induces BSE-like plaques

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A cellular gene encodes scrapie PrP 27-30 protein

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7 January 2021

Measurement of the scrapie agent using an incubation time interval assay

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7 January 2021

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.

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7 January 2021

Eight prion strains have PrP(Sc) molecules with different conformations

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7 January 2021

No propagation of prions in mice devoid of PrP.

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7 January 2021

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Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions

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Prion protein of 106 residues creates an artifical transmission barrier for prion replication in transgenic mice

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7 January 2021

Regional mapping of prion proteins in brain

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7 January 2021

Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice

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7 January 2021

Copper binding to the prion protein: structural implications of four identical cooperative binding sites

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7 January 2021

Prion encephalopathy with insertion of octapeptide repeats: the number of repeats determines the type of cerebellar deposits.

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7 January 2021

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7 January 2021

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7 January 2021

Genetic manipulation of mammals and its application in reproductive biology

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7 January 2021

Prion protein expression in different species: analysis with a panel of new mAbs

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7 January 2021

Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein

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7 January 2021

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Identifiers

DOI

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24 May 2018

release_it72jwp7kjcqloxnvtdqgmsld4

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24 November 2022

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24 May 2018