Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M (Q57006811)

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12 February 2020

title

Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M (English)

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Frank J Dekker

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Gemma Triola

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Herbert Waldmann

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author name string

Marion Rusch

1

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Kristina Görmer

5

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Andreas Brockmeyer

7

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Petra Janning

8

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Thomas Böttcher

9

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Christian Hedberg

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Tobias J Zimmermann

2

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Stephan A Sieber

10

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Ingrid R Vetter

11

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language of work or name

English

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publication date

9 September 2011

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Angewandte Chemie International Edition

12 February 2020

published in

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volume

50

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issue

42

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page(s)

9838-9842

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Ras proteins: different signals from different locations

12 February 2020

cites work

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Ras-MAPK pathway as a therapeutic target in cancer--emphasis on bladder cancer.

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An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

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Small-molecule inhibition of APT1 affects Ras localization and signaling

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Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus

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Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.

21 January 2018

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Activity-based proteome profiling of potential cellular targets of Orlistat--an FDA-approved drug with anti-tumor activities

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Profiling enzyme activities in vivo using click chemistry methods

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Bioorthogonal organic chemistry in living cells: novel strategies for labeling biomolecules

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Thematic review series: lipid posttranslational modifications. Lysosomal metabolism of lipid-modified proteins

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The antiproliferative agent didemnin B uncompetitively inhibits palmitoyl protein thioesterase

21 January 2018

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A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS)

21 January 2018

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Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein alpha subunit deacylation in vivo

21 January 2018

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Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca(2+)-calmodulin

21 January 2018

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Bioorganic synthesis of lipid-modified proteins for the study of signal transduction.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201102967

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12 February 2020

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