Ras proteins: different signals from different locations (Q35120159)

6 August 2017

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title

Ras proteins: different signals from different locations (English)

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6 August 2017

John F Hancock

1

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6 August 2017

publication date

1 May 2003

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Nature Reviews Molecular Cell Biology

6 August 2017

published in

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6 August 2017

volume

4

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6 August 2017

issue

5

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6 August 2017

page(s)

373-384

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Ras and relatives--job sharing and networking keep an old family together

6 August 2017

cites work

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The murine N-ras gene is not essential for growth and development

31 March 2020

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K-ras is an essential gene in the mouse with partial functional overlap with N-ras

31 March 2020

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K-ras is essential for the development of the mouse embryo

31 March 2020

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Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

31 March 2020

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Ras isoforms vary in their ability to activate Raf-1 and phosphoinositide 3-kinase

31 March 2020

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Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility

31 March 2020

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Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo

31 March 2020

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Endogenous c-N-Ras provides a steady-state anti-apoptotic signal

31 March 2020

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Differential activation of the Rac pathway by Ha-Ras and K-Ras

31 March 2020

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The p21 ras C-terminus is required for transformation and membrane association

31 March 2020

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All ras proteins are polyisoprenylated but only some are palmitoylated

31 March 2020

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p21ras is modified by a farnesyl isoprenoid

31 March 2020

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Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

31 March 2020

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Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

31 March 2020

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Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

31 March 2020

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Cloning and characterization of a mammalian prenyl protein-specific protease

31 March 2020

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Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum

31 March 2020

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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

31 March 2020

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

31 March 2020

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A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

31 March 2020

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H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway

31 March 2020

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Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

31 March 2020

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Isoprenylcysteine carboxyl methyltransferase deficiency in mice

31 March 2020

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Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

31 March 2020

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Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae

31 March 2020

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Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae.

31 March 2020

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Erf4p and Erf2p form an endoplasmic reticulum-associated complex involved in the plasma membrane localization of yeast Ras proteins

31 March 2020

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Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins

31 March 2020

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Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi

31 March 2020

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Mutational and biochemical analysis of plasma membrane targeting mediated by the farnesylated, polybasic carboxy terminus of K-ras4B

31 March 2020

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Prenylation-dependent association of Ki-Ras with microtubules. Evidence for a role in subcellular trafficking

31 March 2020

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The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules

31 March 2020

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A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65

31 March 2020

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S-Nitrosocysteine increases palmitate turnover on Ha-Ras in NIH 3T3 cells.

31 March 2020

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S-Acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-ras in mammalian fibroblasts

31 March 2020

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Activation and depalmitoylation of Gs alpha

31 March 2020

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Inhibition of brain Gz GAP and other RGS proteins by palmitoylation of G protein alpha subunits

31 March 2020

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Lipid rafts and signal transduction

31 March 2020

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Separation of "glycosphingolipid signaling domain" from caveolin-containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling

31 March 2020

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Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated.

31 March 2020

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Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane

31 March 2020

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Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK).

31 March 2020

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Unexpectedly strong binding of a large metal ion (Bi3+) to human serum transferrin

31 March 2020

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Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae

31 March 2020

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GTP-dependent segregation of H-ras from lipid rafts is required for biological activity

31 March 2020

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Activation of mitogen-activated protein kinase by membrane-targeted Raf chimeras is independent of raft localization

31 March 2020

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The linker domain of the Ha-Ras hypervariable region regulates interactions with exchange factors, Raf-1 and phosphoinositide 3-kinase

31 March 2020

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The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes

31 March 2020

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Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

31 March 2020

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Direct visualization of Ras proteins in spatially distinct cell surface microdomains

31 March 2020

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Kinetics of interaction of the myristoylated alanine-rich C kinase substrate, membranes, and calmodulin

31 March 2020

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Electrostatic properties of membranes containing acidic lipids and adsorbed basic peptides: theory and experiment

31 March 2020

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Lateral sequestration of phosphatidylinositol 4,5-bisphosphate by the basic effector domain of myristoylated alanine-rich C kinase substrate is due to nonspecific electrostatic interactions

31 March 2020

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Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling

31 March 2020

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Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts

31 March 2020

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Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation

31 March 2020

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Rab proteins as membrane organizers

31 March 2020

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Galectin-1 Augments Ras Activation and Diverts Ras Signals to Raf-1 at the Expense of Phosphoinositide 3-Kinase

31 March 2020

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The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases

31 March 2020

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The complex of Arl2-GTP and PDE delta: from structure to function

31 March 2020

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A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation

31 March 2020

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Transient palmitoylation supports H-Ras membrane binding but only partial biological activity

31 March 2020

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Mutation of Ha-Ras C Terminus Changes Effector Pathway Utilization

31 March 2020

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Inhibition of lipid raft-dependent signaling by a dystrophy-associated mutant of caveolin-3.

31 March 2020

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Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

31 March 2020

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Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation

31 March 2020

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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

31 March 2020

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Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells

31 March 2020

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NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway

31 March 2020

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Agonist-dependent traffic of raft-associated Ras and Raf-1 is required for activation of the mitogen-activated protein kinase cascade

31 March 2020

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Spatio-temporal images of growth-factor-induced activation of Ras and Rap1.

31 March 2020

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Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1.

31 March 2020

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Mechanism of the spatio-temporal regulation of Ras and Rap1.

31 March 2020

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Ras signalling on the endoplasmic reticulum and the Golgi

31 March 2020

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Regulation of RasGRP via a phorbol ester-responsive C1 domain.

31 March 2020

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RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

31 March 2020

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CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway

31 March 2020

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N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization

31 March 2020

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Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes

31 March 2020

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Derivatives of activated H-ras lacking C-terminal lipid modifications retain transforming ability if targeted to the correct subcellular location

31 March 2020

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

31 March 2020

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Activation of Raf as a result of recruitment to the plasma membrane

31 March 2020

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Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment

31 March 2020

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The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.

31 March 2020

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Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking

31 March 2020

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Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts

31 March 2020

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Associations of B- and C-Raf with cholesterol, phosphatidylserine, and lipid second messengers: preferential binding of Raf to artificial lipid rafts.

31 March 2020

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Control of EGF receptor signaling by clathrin-mediated endocytosis.

31 March 2020

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Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways

31 March 2020

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Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase

31 March 2020

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Signal transduction and endocytosis: close encounters of many kinds

31 March 2020

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H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis

31 March 2020

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A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1

31 March 2020

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Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

31 March 2020

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

31 March 2020

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Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry

31 March 2020

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Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo

31 March 2020

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Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor

31 March 2020

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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

31 March 2020

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Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

31 March 2020

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Dephosphorylation of Ser-259 regulates Raf-1 membrane association

31 March 2020

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

31 March 2020

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14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

31 March 2020

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Interactions of c-Raf-1 with phosphatidylserine and 14-3-3.

31 March 2020

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Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

31 March 2020

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Activation of phosphoinositide 3-kinase gamma by Ras.

31 March 2020

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Structure and origin of ordered lipid domains in biological membranes.

31 March 2020

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A detergent-free method for purifying caveolae membrane from tissue culture cells

31 March 2020

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Regulating c-Ras function. cholesterol depletion affects caveolin association, GTP loading, and signaling

31 March 2020

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Lipid domain structure of the plasma membrane revealed by patching of membrane components

31 March 2020

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Cross-correlation analysis of inner-leaflet-anchored green fluorescent protein co-redistributed with IgE receptors and outer leaflet lipid raft components

31 March 2020

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High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT.

31 March 2020

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Caveolin and ras function

31 March 2020

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Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies.

31 March 2020

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Structural determinants of Ras-Raf interaction analyzed in live cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1105

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6 August 2017

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