The role of tumour microenvironment: a new vision for cholangiocarcinoma (Q58610756)

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1 May 2020

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8 September 2020

The role of tumour microenvironment: a new vision for cholangiocarcinoma (English)

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1 May 2020

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8 September 2020

tumor microenvironment

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8 September 2020

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8 September 2020

4

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1 May 2020

author name string

Ziyan Chen

1

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1 May 2020

Pengyi Guo

2

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1 May 2020

Xiaozai Xie

3

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1 May 2020

Yi Wang

5

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1 May 2020

Gang Chen

6

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language of work or name

English

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publication date

5 November 2018

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30394682%20AND%20SRC:MED&resulttype=core&format=json

Journal of Cellular and Molecular Medicine

1 May 2020

1 January 2019

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8 September 2020

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8 September 2020

23

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issue

1

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1 May 2020

page(s)

59-69

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Creative Commons Attribution

1 May 2020

copyright license

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8 September 2020

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Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

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12 December 2020

Genetic instability induced by the tumor microenvironment.

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12 December 2020

Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.

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12 December 2020

Suppression of tumor growth through disruption of hypoxia-inducible transcription

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12 December 2020

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

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12 December 2020

Tumor hepatocytes and basement membrane-Producing cells specifically express two different forms of the endostatin precursor, collagen XVIII, in human liver cancers

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12 December 2020

Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis

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12 December 2020

Inflammation and cancer

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12 December 2020

Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study

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12 December 2020

Immunohistochemical and mutational analyses of Wnt signaling components and target genes in intrahepatic cholangiocarcinomas.

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12 December 2020

Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma

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12 December 2020

Hypoxia signalling in cancer and approaches to enforce tumour regression

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12 December 2020

Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma

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12 December 2020

Synemin expression is widespread in liver fibrosis and is induced in proliferating and malignant biliary epithelial cells

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12 December 2020

Cholangiocarcinoma: thirty-one-year experience with 564 patients at a single institution

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12 December 2020

Mast cells show their might

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12 December 2020

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

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12 December 2020

Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma

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12 December 2020

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

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12 December 2020

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

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12 December 2020

Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma

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12 December 2020

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase.

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12 December 2020

High lifetime risk of cancer in primary sclerosing cholangitis

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12 December 2020

Alpha-smooth muscle actin-positive fibroblasts promote biliary cell proliferation and correlate with poor survival in cholangiocarcinoma

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12 December 2020

Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression

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12 December 2020

Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis.

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12 December 2020

Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker

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12 December 2020

Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis

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12 December 2020

Tumor cell behaviour modulation by mesenchymal stromal cells.

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12 December 2020

Dying dangerously: Necrotic cell death and chronic inflammation promote tumor growth

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12 December 2020

Angiotensin II induces tumor progression and fibrosis in intrahepatic cholangiocarcinoma through an interaction with hepatic stellate cells

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12 December 2020

Hepatic stellate cells accelerate the malignant behavior of cholangiocarcinoma cells

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12 December 2020

Tissue invasive macrophage density is correlated with prognosis in cholangiocarcinoma

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12 December 2020

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway.

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12 December 2020

Hypoxia inducible factor expression in intrahepatic cholangiocarcinoma

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12 December 2020

E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma

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12 December 2020

Identification of CXCL5/ENA-78 as a factor involved in the interaction between cholangiocarcinoma cells and cancer-associated fibroblasts

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12 December 2020

Intratumoral IL-17⁺ cells and neutrophils show strong prognostic significance in intrahepatic cholangiocarcinoma

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12 December 2020

The immune contexture in human tumours: impact on clinical outcome

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12 December 2020

Periostin activates integrin α5β1 through a PI3K/AKT‑dependent pathway in invasion of cholangiocarcinoma

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12 December 2020

Tumor necrosis factor-α (TNF-α) stimulates the epithelial-mesenchymal transition regulator Snail in cholangiocarcinoma

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12 December 2020

The tumorigenic liver fluke Opisthorchis viverrini--multiple pathways to cancer

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12 December 2020

Mast cells and inflammation-associated colorectal carcinogenesis

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12 December 2020

Cholangiocarcinoma pathogenesis: Role of the tumor microenvironment

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12 December 2020

Mesenchymal stem cell 1 (MSC1)-based therapy attenuates tumor growth whereas MSC2-treatment promotes tumor growth and metastasis

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12 December 2020

Characterization of the erythropoietin/erythropoietin receptor axis in a rat model of liver damage and cholangiocarcinoma development

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12 December 2020

Interleukin-1β mediates metalloproteinase-dependent renal cell carcinoma tumor cell invasion through the activation of CCAAT enhancer binding protein β

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12 December 2020

Notch-driven carcinogenesis: the merging of hepatocellular cancer and cholangiocarcinoma into a common molecular liver cancer subtype

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12 December 2020

Bile acids affect the growth of human cholangiocarcinoma via NF-kB pathway

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12 December 2020

Hypoxia enhances aggressiveness of cholangiocarcinoma cells.

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12 December 2020

Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma

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12 December 2020

miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF).

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12 December 2020

Suppression of cholangiocarcinoma cell growth by human umbilical cord mesenchymal stem cells: a possible role of Wnt and Akt signaling

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12 December 2020

Inhibition of Wnt signaling induces cell apoptosis and suppresses cell proliferation in cholangiocarcinoma cells

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12 December 2020

Isolation and characterization of biliary epithelial and stromal cells from resected human cholangiocarcinoma: a novel in vitro model to study tumor-stroma interactions

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12 December 2020

Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model

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12 December 2020

Inhibition of Wnt/β-catenin signaling downregulates P-glycoprotein and reverses multi-drug resistance of cholangiocarcinoma

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12 December 2020

A model of liver carcinogenesis originating from hepatic progenitor cells with accumulation of genetic alterations.

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12 December 2020

Diethyldithiocarbamate suppresses an NF-kappaB dependent metastatic pathway in cholangiocarcinoma cells.

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12 December 2020

Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway

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12 December 2020

Gankyrin promotes tumor growth and metastasis through activation of IL-6/STAT3 signaling in human cholangiocarcinoma.

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12 December 2020

Activation of Notch signaling is required for cholangiocarcinoma progression and is enhanced by inactivation of p53 in vivo

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12 December 2020

Stellate cells and the development of liver cancer: therapeutic potential of targeting the stroma

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12 December 2020

Activated macrophages promote Wnt/β-catenin signaling in cholangiocarcinoma cells

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12 December 2020

Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma.

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12 December 2020

Hedgehog signaling between cancer cells and hepatic stellate cells in promoting cholangiocarcinoma

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12 December 2020

EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition.

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12 December 2020

Role of desmoplasia in cholangiocarcinoma and hepatocellular carcinoma.

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12 December 2020

The cellular and molecular origin of tumor-associated macrophages

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12 December 2020

Proteomic identification of potential Clonorchis sinensis excretory/secretory products capable of binding and activating human hepatic stellate cells

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12 December 2020

Characterization of EGFR family gene aberrations in cholangiocarcinoma

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12 December 2020

BMP-7 blocks the effects of TGF-β-induced EMT in cholangiocarcinoma

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12 December 2020

STATs profiling reveals predominantly-activated STAT3 in cholangiocarcinoma genesis and progression

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12 December 2020

High expression of HIF-1α, BNIP3 and PI3KC3: hypoxia-induced autophagy predicts cholangiocarcinoma survival and metastasis

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12 December 2020

TGF-β isoforms induce EMT independent migration of ovarian cancer cells

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12 December 2020

Differential effects of targeting Notch receptors in a mouse model of liver cancer

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12 December 2020

Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates inflammation signaling in human hepatic stellate cells

1 reference

12 December 2020

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

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12 December 2020

Surgical procedure and long-term survival of hilar cholangiocarcinoma

1 reference

12 December 2020

DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status

1 reference

12 December 2020

Quantitative changes in tumor-associated M2 macrophages characterize cholangiocarcinoma and their association with metastasis

1 reference

12 December 2020

Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

1 reference

12 December 2020

Profiles of cancer stem cell subpopulations in cholangiocarcinomas.

1 reference

12 December 2020

Hypoxia enhances cholangiocarcinoma invasion through activation of hepatocyte growth factor receptor and the extracellular signal‑regulated kinase signaling pathway

1 reference

12 December 2020

Expression and activation of EGFR and STAT3 during the multistage carcinogenesis of intrahepatic cholangiocarcinoma induced by 3'-methyl-4 dimethylaminoazobenzene in rats

1 reference

12 December 2020

Underexpression of LKB1 tumor suppressor is associated with enhanced Wnt signaling and malignant characteristics of human intrahepatic cholangiocarcinoma

1 reference

12 December 2020

Proteomics profiling of cholangiocarcinoma exosomes: A potential role of oncogenic protein transferring in cancer progression

1 reference

12 December 2020

Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2α/androgen receptor signals

1 reference

12 December 2020

Tumor Microenvironment Versus Cancer Stem Cells in Cholangiocarcinoma: Synergistic Effects?

1 reference

12 December 2020

Prognostic significance of macrophage invasion in hilar cholangiocarcinoma

1 reference

12 December 2020

Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche.

1 reference

12 December 2020

Inhibition of Mast Cell-Derived Histamine Decreases Human Cholangiocarcinoma Growth and Differentiation via c-Kit/Stem Cell Factor-Dependent Signaling

1 reference

12 December 2020

Tumor Specific Recruitment and Reprogramming of Mesenchymal Stem Cells in Tumorigenesis

1 reference

12 December 2020

Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma

1 reference

12 December 2020

Immunosuppression of breast cancer cells mediated by transforming growth factor-β in exosomes from cancer cells

1 reference

12 December 2020

TGF-β Tumor Suppression through a Lethal EMT.

1 reference

12 December 2020

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

1 reference

12 December 2020

Aspirin use and the risk of cholangiocarcinoma

1 reference

12 December 2020

WAVE3 Induces EMT and Promotes Migration and Invasion in Intrahepatic Cholangiocarcinoma

1 reference

12 December 2020

Characterizing the activation of the Wnt signaling pathway in hilar cholangiocarcinoma using a tissue microarray approach

1 reference

12 December 2020

Program Death 1 Immune Checkpoint and Tumor Microenvironment: Implications for Patients With Intrahepatic Cholangiocarcinoma

1 reference

12 December 2020

Cholangiocarcinoma-derived exosomes inhibit the antitumor activity of cytokine-induced killer cells by down-regulating the secretion of tumor necrosis factor-α and perforin

1 reference

12 December 2020

Impact of the Tumor Microenvironment on the Expression of Inflammatory Mediators in Cancer Cells.

1 reference

12 December 2020

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers

1 reference

12 December 2020

Protein tyrosine phosphatase PTP4A1 promotes proliferation and epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma via the PI3K/AKT pathway

1 reference

12 December 2020

Notch3 drives development and progression of cholangiocarcinoma.

1 reference

12 December 2020

Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans

1 reference

12 December 2020

Molecular Checkpoint Decisions Made by Subverted Vascular Niche Transform Indolent Tumor Cells into Chemoresistant Cancer Stem Cells

1 reference

12 December 2020

The tumor microenvironment promotes cancer progression and cell migration

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12 December 2020

Expression and clinical relevance of epithelial and mesenchymal markers in circulating tumor cells from colorectal cancer

1 reference

12 December 2020

The microenvironment in primary cutaneous melanoma with associated spontaneous tumor regression: evaluation for T-regulatory cells and the presence of an immunosuppressive microenvironment.

1 reference

12 December 2020

miR-21 and KLF4 jointly augment epithelial‑mesenchymal transition via the Akt/ERK1/2 pathway

1 reference

12 December 2020

MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression

1 reference

12 December 2020

PD-L1 expression in extrahepatic cholangiocarcinoma

1 reference

12 December 2020

PD-L1 expression in perihilar and intrahepatic cholangiocarcinoma.

1 reference

12 December 2020

Bu Fei Decoction attenuates the tumor associated macrophage stimulated proliferation, migration, invasion and immunosuppression of non-small cell lung cancer, partially via IL-10 and PD-L1 regulation

1 reference

12 December 2020

Berberine Induces Cell Cycle Arrest in Cholangiocarcinoma Cell Lines via Inhibition of NF-κB and STAT3 Pathways

1 reference

12 December 2020

aPKC-ι/P-Sp1/Snail signaling induces epithelial-mesenchymal transition and immunosuppression in cholangiocarcinoma

1 reference

12 December 2020

Macrophage colony stimulating factor enhances non-small cell lung cancer invasion and metastasis by promoting macrophage M2 polarization

1 reference

12 December 2020

Growth inhibitory effect of β-eudesmol on cholangiocarcinoma cells and its potential suppressive effect on heme oxygenase-1 production, STAT1/3 activation, and NF-κB downregulation

1 reference

12 December 2020

Magnolol suppresses the proliferation and invasion of cholangiocarcinoma cells via inhibiting the NF-κB signaling pathway

1 reference

12 December 2020

TGF-β signaling is an effective target to impair survival and induce apoptosis of human cholangiocarcinoma cells: A study on human primary cell cultures

1 reference

12 December 2020

Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma

1 reference

12 December 2020

Mesenchymal stem cells in inflammatory microenvironment potently promote metastatic growth of cholangiocarcinoma via activating Akt/NF-κB signaling by paracrine CCL5.

1 reference

12 December 2020

Tumour-infiltrating inflammatory and immune cells in patients with extrahepatic cholangiocarcinoma

1 reference

12 December 2020

Elevated TRIM44 promotes intrahepatic cholangiocarcinoma progression by inducing cell EMT via MAPK signaling.

1 reference

12 December 2020

Prognostic value of CD8CD45RO tumor infiltrating lymphocytes in patients with extrahepatic cholangiocarcinoma.

1 reference

12 December 2020

Inhibiting the proliferation and metastasis of hilar cholangiocarcinoma cells by blocking the expression of vascular endothelial growth factor with small interfering RNA

1 reference

12 December 2020

Isolation of cancer-associated fibroblasts and its promotion to the progression of intrahepatic cholangiocarcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1111/JCMM.13953

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30394682%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30394682%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

PubMed publication ID

30394682

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