N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease (Q50101151)

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scientific article published on 10 January 2018

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English	N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease	scientific article published on 10 January 2018

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scholarly article

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PMC publication ID

24 February 2018

http://europepmc.org/abstract/PMC/5762728

N-domain of angiotensin-converting enzyme hydrolyzes human and rat amyloid-β(1-16) peptides as arginine specific endopeptidase potentially enhancing risk of Alzheimer's disease (English)

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PMC publication ID

24 February 2018

http://europepmc.org/abstract/PMC/5762728

Alzheimer's disease

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5

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3 June 2020

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3 June 2020

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3 June 2020

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Elena V Kugaevskaya

1

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3 June 2020

Alexander V Veselovsky

2

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3 June 2020

Maria I Indeykina

3

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3 June 2020

Nina I Solovyeva

4

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3 June 2020

Eugene N Nikolaev

7

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3 June 2020

Alexey B Mantsyzov

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3 June 2020

Alexander A Makarov

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10 January 2018

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Scientific Reports

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3 June 2020

8

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3 June 2020

1

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3 June 2020

298

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3 June 2020

copyright license

Creative Commons Attribution 4.0 International

10 January 2018

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MCPB.py: A Python Based Metal Center Parameter Builder

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22 May 2018

Interplay of histidine residues of the Alzheimer's disease Aβ peptide governs its Zn-induced oligomerization

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Intracerebral Injection of Metal-Binding Domain of Aβ Comprising the Isomerized Asp7 Increases the Amyloid Burden in Transgenic Mice

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Effects of Hypertension and Anti-Hypertensive Treatment on Amyloid-β (Aβ) Plaque Load and Aβ-Synthesizing and Aβ-Degrading Enzymes in Frontal Cortex

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22 May 2018

Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme.

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22 May 2018

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22 May 2018

Zinc-induced heterodimer formation between metal-binding domains of intact and naturally modified amyloid-beta species: implication to amyloid seeding in Alzheimer's disease?

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22 May 2018

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

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Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies

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Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

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22 May 2018

ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer's disease

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22 May 2018

Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia

1 reference

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22 May 2018

Catalytic mechanism of angiotensin-converting enzyme and effects of the chloride ion.

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22 May 2018

Peripherally applied synthetic peptide isoAsp7-Aβ(1-42) triggers cerebral β-amyloidosis

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22 May 2018

Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide

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22 May 2018

Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis.

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22 May 2018

Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides

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22 May 2018

NMR solution structure of rat aβ(1-16): toward understanding the mechanism of rats' resistance to Alzheimer's disease

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22 May 2018

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?

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22 May 2018

The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis

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22 May 2018

Inhibitor and substrate binding by angiotensin-converting enzyme: quantum mechanical/molecular mechanical molecular dynamics studies.

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22 May 2018

ACE variants and association with brain Aβ levels in Alzheimer's disease

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22 May 2018

Vascular basis for brain degeneration: faltering controls and risk factors for dementia

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22 May 2018

Structural Survey of Zinc-Containing Proteins and Development of the Zinc AMBER Force Field (ZAFF)

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22 May 2018

Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states

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Vascular risk factor detection and control may prevent Alzheimer's disease

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22 May 2018

Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes.

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22 May 2018

Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-beta peptides

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22 May 2018

The N-domain of angiotensin-converting enzyme specifically hydrolyzes the Arg-5-His-6 bond of Alzheimer's Abeta-(1-16) peptide and its isoAsp-7 analogue with different efficiency as evidenced by quantitative matrix-assisted laser [...]

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22 May 2018

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

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Update on hypertension and Alzheimer's disease

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Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

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Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease

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Crystal structure of the human angiotensin-converting enzyme-lisinopril complex

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Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

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Alzheimer's disease: genes, proteins, and therapy

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Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence

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Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact

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Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning

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The broad substrate specificity of human angiotensin I converting enzyme

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22 May 2018

Arginine specific endopeptidases modify the aggregation properties of a synthetic peptide derived from Alzheimer beta/A4 amyloid

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Effects of centrally acting angiotensin converting enzyme inhibitors on functional decline in patients with Alzheimer's disease.

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14 August 2018

Identification of the minimal zinc-binding center in natural isoforms of amyloid-beta domain 1-16 using ESI-MS

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14 August 2018

Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias

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14 August 2018

Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease.

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14 August 2018

Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease

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14 August 2018

Prevalence and impact of cerebrovascular lesions in Alzheimer and lewy body diseases

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14 August 2018

Angiotensin converting enzyme inhibitors and cognitive and functional decline in patients with Alzheimer's disease: an observational study.

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14 August 2018

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14 August 2018

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The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide.

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14 August 2018

Angiotensin Converting Enzyme in Alzheimer's Disease: Increased Activity in Caudate Nucleus and Cortical Areas

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14 August 2018

Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

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21 January 2018

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21 January 2018

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

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21 January 2018

Amyloid-β containing isoaspartate 7 as potential biomarker and drug target in Alzheimer's disease

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21 January 2018

ESI-MS identification of the minimal zinc-binding center in natural isoforms of β-amyloid domain 1–16

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21 January 2018

Capabilities of MS for Analytical Quantitative Determination of the Ratio of α- and βAsp7 Isoforms of the Amyloid-β Peptide in Binary Mixtures

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21 January 2018

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

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21 January 2018

Zinc Binding to Alzheimer's Aβ(1–16) Peptide Results in Stable Soluble Complex

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30 November 2018

Alzheimer's disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population

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https://api.crossref.org/works/10.1038%2FS41598-017-18567-5

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/S41598-017-18567-5

1 reference

Europe PubMed Central

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3 June 2020

PMC publication ID

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Europe PubMed Central

PMC publication ID

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3 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

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3 June 2020

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