The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. (Q51565310)

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1 February 2020

title

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling (English)

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Richard Houlston

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Jian Yan

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Jukka-Pekka Mecklin

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Philip East

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Heikki Järvinen

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Ian Tomlinson

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author name string

Sari Tuupanen

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Outi Hallikas

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Sakari Vanharanta

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Teemu Kivioja

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Iina Niittymäki

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Ari Ristimäki

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Mariachiara Di-Bernardo

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Luis Carvajal-Carmona

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Jussi Taipale

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language of work or name

English

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publication date

28 June 2009

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volume

41

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issue

8

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page(s)

885-890

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Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

1 February 2020

cites work

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12 December 2020

Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen

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Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge

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A common genetic risk factor for colorectal and prostate cancer

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Patched acts catalytically to suppress the activity of Smoothened

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Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk

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Linking colorectal cancer to Wnt signaling

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Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing

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Genetic variation in 8q24 associated with risk of colorectal cancer

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Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry

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Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity

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Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during development

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Investigation of the colorectal cancer susceptibility region on chromosome 8q24.21 in a large German case-control sample

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High-throughput assay for determining specificity and affinity of protein-DNA binding interactions

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Requirement for beta-catenin in anterior-posterior axis formation in mice

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Modelling Myc inhibition as a cancer therapy

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Allelic Imbalance at rs6983267 Suggests Selection of the Risk Allele in Somatic Colorectal Tumor Evolution

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Genome-wide analysis of transcript isoform variation in humans

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The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

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Population-based molecular detection of hereditary nonpolyposis colorectal cancer

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Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers

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Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube

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Beta-catenin signaling is required for neural differentiation of embryonic stem cells

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Diversity and complexity in DNA recognition by transcription factors

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Functional analysis of cis-regulatory elements controlling initiation and maintenance of early Cdx1 gene expression in the mouse

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Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer

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Haploview: analysis and visualization of LD and haplotype maps

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Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

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Serial analysis of chromatin occupancy identifies beta-catenin target genes in colorectal carcinoma cells

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12 December 2020

The Intestinal Wnt/TCF Signature.

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Locating potential enhancer elements by comparative genomics using the EEL software

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Myc deletion rescues Apc deficiency in the small intestine

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Genome-wide association. Closing the net on common disease genes

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Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk

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Cumulative association of five genetic variants with prostate cancer

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Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

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A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

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Wnt signaling as a therapeutic target for cancer

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Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

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Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease

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A common 8q24 variant and the risk of colon cancer: a population-based case-control study.

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A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3

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Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

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Selective use of multiple vitamin D response elements underlies the 1 alpha,25-dihydroxyvitamin D3-mediated negative regulation of the human CYP27B1 gene

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