Drugging in the absence of p53 (Q64107799)

Europe PubMed Central

8 February 2021

Europe PubMed Central

Ultraviolet hypermutability of a shuttle vector propagated in xeroderma pigmentosum variant cells

31 July 2022

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12 December 2020

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

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12 December 2020

p53 induced by ionizing radiation mediates DNA end-jointing activity, but not apoptosis of thyroid cells

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12 December 2020

Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53

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12 December 2020

A role for p53 in DNA end rejoining by human cell extracts

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12 December 2020

Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice.

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12 December 2020

Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

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12 December 2020

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

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12 December 2020

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis

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12 December 2020

Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant

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12 December 2020

p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts

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12 December 2020

Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.

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12 December 2020

ATM protein expression correlates with radioresistance in primary glioblastoma cells in culture

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12 December 2020

p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

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12 December 2020

The Y-family of DNA polymerases

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12 December 2020

Homologous recombination in extrachromosomal plasmid substrates is not suppressed by p53.

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12 December 2020

P53-dependent expression of the stress-induced protein (SIP).

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12 December 2020

Association of p53 and MSH2 with recombinative repair complexes during S phase

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12 December 2020

Wild-type p53 inhibits replication-associated homologous recombination

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12 December 2020

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.

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12 December 2020

BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

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12 December 2020

PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse

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12 December 2020

p53 Activation in Adipocytes of Obese Mice

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12 December 2020

Recapitulation of the cellular xeroderma pigmentosum-variant phenotypes using short interfering RNA for DNA polymerase H.

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12 December 2020

p53-deficient cells display increased sensitivity to anthracyclines after loss of the catalytic subunit of the DNA-dependent protein kinase

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12 December 2020

Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor

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12 December 2020

Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

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12 December 2020

p53's double life: transactivation-independent repression of homologous recombination.

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12 December 2020

The interaction of p53 with replication protein A mediates suppression of homologous recombination

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12 December 2020

Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53

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12 December 2020

p53: traffic cop at the crossroads of DNA repair and recombination

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12 December 2020

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

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12 December 2020

The coordinate regulation of the p53 and mTOR pathways in cells

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12 December 2020

The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme

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12 December 2020

p53 in recombination and repair

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12 December 2020

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

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12 December 2020

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway

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12 December 2020

DRAM links autophagy to p53 and programmed cell death

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12 December 2020

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

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12 December 2020

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

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12 December 2020

p53 suppression overwhelms DNA polymerase eta deficiency in determining the cellular UV DNA damage response

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12 December 2020

DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

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12 December 2020

Reversible compartmentalization of de novo purine biosynthetic complexes in living cells

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12 December 2020

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

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12 December 2020

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy

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12 December 2020

Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function

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12 December 2020

The combined status of ATM and p53 link tumor development with therapeutic response

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12 December 2020

Modulation of intracellular ROS levels by TIGAR controls autophagy

1 reference

12 December 2020

Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53.

1 reference

12 December 2020

GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress

1 reference

12 December 2020

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

1 reference

12 December 2020

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

1 reference

12 December 2020

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

1 reference

12 December 2020

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

1 reference

12 December 2020

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

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12 December 2020

ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress

1 reference

12 December 2020

p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2

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12 December 2020

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

1 reference

12 December 2020

p53 modulates homologous recombination at I-SceI-induced double-strand breaks through cell-cycle regulation

1 reference

12 December 2020

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

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12 December 2020

Interference between DNA replication and transcription as a cause of genomic instability

1 reference

12 December 2020

Seeking synergy in p53 transcriptional activation for cancer therapy

1 reference

12 December 2020

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

1 reference

12 December 2020

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

1 reference

12 December 2020

Drugging topoisomerases: lessons and challenges

1 reference

12 December 2020

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

1 reference

12 December 2020

Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model

1 reference

12 December 2020

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

1 reference

12 December 2020

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

1 reference

12 December 2020

Serine, glycine and one-carbon units: cancer metabolism in full circle

1 reference

12 December 2020

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

1 reference

12 December 2020

Chaperone-mediated autophagy degrades mutant p53.

1 reference

12 December 2020

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors

1 reference

12 December 2020

ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

1 reference

12 December 2020

Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism

1 reference

12 December 2020

Causes and consequences of replication stress

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12 December 2020

Unravelling mechanisms of p53-mediated tumour suppression

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12 December 2020

Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells.

1 reference

12 December 2020

Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation.

1 reference

12 December 2020

Modulation of the poly (ADP-ribose) polymerase inhibitor response and DNA recombination in breast cancer cells by drugs affecting endogenous wild-type p53.

1 reference

12 December 2020

Hexokinase 2-mediated Warburg effect is required for PTEN- and p53-deficiency-driven prostate cancer growth

1 reference

12 December 2020

Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ)

1 reference

12 December 2020

Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function

1 reference

12 December 2020

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

1 reference

12 December 2020

Hitting cancers' weak spots: vulnerabilities imposed by p53 mutation

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12 December 2020

Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities

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12 December 2020

Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations

1 reference

12 December 2020

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells.

1 reference

12 December 2020

Clinical Overview of MDM2/X-Targeted Therapies

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12 December 2020

Spatial colocalization and functional link of purinosomes with mitochondria.

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12 December 2020

p53 Maintains Genomic Stability by Preventing Interference between Transcription and Replication.

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12 December 2020

The DNA fibre technique - tracking helicases at work

1 reference

12 December 2020

Systematic Analysis Reveals that Cancer Mutations Converge on Deregulated Metabolism of Arachidonate and Xenobiotics.

1 reference

12 December 2020

DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression

1 reference

12 December 2020

The importance of serine metabolism in cancer

1 reference

12 December 2020

Serine and one-carbon metabolism in cancer

1 reference

12 December 2020

A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining

1 reference

12 December 2020

p53 Activity Results in DNA Replication Fork Processivity.

1 reference

12 December 2020

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.

1 reference

12 December 2020

Exploiting the p53 Pathway for Therapy.

1 reference

12 December 2020

Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapy: Progress and Challenges.

1 reference

12 December 2020

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

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12 December 2020

Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells.

1 reference

12 December 2020

From Krebs to clinic: glutamine metabolism to cancer therapy

1 reference

12 December 2020

Targeting autophagy in cancer

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12 December 2020

p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways.

1 reference

12 December 2020

High speed of fork progression induces DNA replication stress and genomic instability

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12 December 2020

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3

1 reference

12 December 2020

Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers

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12 December 2020

Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication

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12 December 2020