Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination (Q90721989)

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15 April 2020

title

Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination (English)

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15 April 2020

author name string

Jennifer L Crowe

1

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15 April 2020

Zhengping Shao

2

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15 April 2020

Xiaobin S Wang

3

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15 April 2020

Wenxia Jiang

5

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15 April 2020

Brian J Lee

6

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15 April 2020

Verna M Estes

7

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15 April 2020

Frederick W Alt

8

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publication date

2 August 2018

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15 April 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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volume

115

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15 April 2020

issue

34

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15 April 2020

page(s)

8615-8620

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Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

15 April 2020

cites work

1 reference

12 December 2020

Tumor spectrum analysis in p53-mutant mice

1 reference

12 December 2020

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

12 December 2020

A Prematurely Expressed Igκ Transgene, but Not a VκJκ Gene Segment Targeted into the Igκ Locus, Can Rescue B Cell Development in λ5-Deficient Mice

1 reference

12 December 2020

B cell development under the condition of allelic inclusion.

1 reference

12 December 2020

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

1 reference

12 December 2020

Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification

1 reference

12 December 2020

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

1 reference

12 December 2020

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

12 December 2020

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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12 December 2020

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

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12 December 2020

DNA-dependent protein kinase activity is not required for immunoglobulin class switching

1 reference

12 December 2020

Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions

1 reference

12 December 2020

An evolutionarily conserved target motif for immunoglobulin class-switch recombination

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12 December 2020

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

1 reference

12 December 2020

Influence of switch region length on immunoglobulin class switch recombination

1 reference

12 December 2020

Interallelic Class Switch Recombination Contributes Significantly to Class Switching in Mouse B Cells

1 reference

12 December 2020

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations

1 reference

12 December 2020

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

1 reference

12 December 2020

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice

1 reference

12 December 2020

Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T.

1 reference

12 December 2020

The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination

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12 December 2020

IgH class switching and translocations use a robust non-classical end-joining pathway

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12 December 2020

S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase

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12 December 2020

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination

1 reference

12 December 2020

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

1 reference

12 December 2020

Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice

1 reference

12 December 2020

Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes

1 reference

12 December 2020

Chromatin architecture and the generation of antigen receptor diversity

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12 December 2020

Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome

1 reference

12 December 2020

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.

1 reference

12 December 2020

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

1 reference

12 December 2020

Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions

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12 December 2020

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation

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12 December 2020

Double-strand break end resection and repair pathway choice

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12 December 2020

Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells

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12 December 2020

Spatial organization of the mouse genome and its role in recurrent chromosomal translocations

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12 December 2020

YAHA: fast and flexible long-read alignment with optimal breakpoint detection

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12 December 2020

Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining

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12 December 2020

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

1 reference

12 December 2020

DNA-PKcs Is Involved in Ig Class Switch Recombination in Human B Cells

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12 December 2020

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

1 reference

12 December 2020

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

1 reference

12 December 2020

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing

1 reference

12 December 2020

PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice

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12 December 2020

Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency

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12 December 2020

Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry.

1 reference

12 December 2020

DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions.

1 reference

12 December 2020

Plasticity of the Mre11-Rad50-Xrs2-Sae2 nuclease ensemble in the processing of DNA-bound obstacles

1 reference

12 December 2020

Physiological protein blocks direct the Mre11-Rad50-Xrs2 and Sae2 nuclease complex to initiate DNA end resection

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1808490115

1 reference

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15 April 2020

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15 April 2020

PubMed publication ID

30072430

1 reference