Discovery of Small-Molecule Antibiotics against a Unique tRNA-Mediated Regulation of Transcription in Gram-Positive Bacteria (Q91304272)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

title

Discovery of Small-Molecule Antibiotics against a Unique tRNA-Mediated Regulation of Transcription in Gram-Positive Bacteria (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

author name string

Kyla M Frohlich

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Spencer F Weintraub

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Janeen T Bell

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Gabrielle C Todd

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Ville Y P Väre

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Ryan Schneider

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Zachary A Kloos

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Ebot S Tabe

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

William A Cantara

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Caren J Stark

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Urenna J Onwuanaibe

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Bryan C Duffy

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Maria Basanta-Sanchez

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Douglas B Kitchen

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Kathleen A McDonough

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

publication date

1 March 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

volume

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

page(s)

758-769

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

Targeting the bacteria-host interface: strategies in anti-adhesion therapy

21 April 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

The research agenda of the National Institute of Allergy and Infectious Diseases for antimicrobial resistance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Acquired inducible antimicrobial resistance in Gram-positive bacteria

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Origins and evolution of antibiotic resistance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Bacterial Adaptation to Antibiotics through Regulatory RNAs.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Role of aminoacyl-tRNA synthetases in infectious diseases and targets for therapeutic development

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Conservation of a transcription antitermination mechanism in aminoacyl-tRNA synthetase and amino acid biosynthesis genes in gram-positive bacteria

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

The T box and S box transcription termination control systems

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Antibiotics that target protein synthesis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Insights into the mechanism of inhibition of novel bacterial topoisomerase inhibitors from characterization of resistant mutants of Staphylococcus aureus

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

From ribosome to riboswitch: control of gene expression in bacteria by RNA structural rearrangements

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Riboswitches as antibacterial drug targets

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Selective small-molecule inhibition of an RNA structural element

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Biochemical features and functional implications of the RNA-based T-box regulatory mechanism

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Comparative genomic analysis of T-box regulatory systems in bacteria

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

The T box mechanism: tRNA as a regulatory molecule

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Riboswitch RNAs: regulation of gene expression by direct monitoring of a physiological signal

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

tRNA regulation of gene expression: interactions of an mRNA 5'-UTR with a regulatory tRNA.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

tRNA as a positive regulator of transcription antitermination in B. subtilis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Riboswitch RNAs: using RNA to sense cellular metabolism

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Analysis of the Bacillus subtilis tyrS gene: conservation of a regulatory sequence in multiple tRNA synthetase genes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

In vitro structure-function studies of the Bacillus subtilis tyrS mRNA antiterminator: evidence for factor-independent tRNA acceptor stem binding specificity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

T box RNA decodes both the information content and geometry of tRNA to affect gene expression

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Solution NMR determination of hydrogen bonding and base pairing between the glyQS T box riboswitch Specifier domain and the anticodon loop of tRNA(Gly).

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

NMR structure and dynamics of the Specifier Loop domain from the Bacillus subtilis tyrS T box leader RNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Early phase drug discovery: cheminformatics and computational techniques in identifying lead series

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Solution structure of the K-turn and Specifier Loop domains from the Bacillus subtilis tyrS T-box leader RNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Antimicrobial susceptibility testing: a review of general principles and contemporary practices

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

In vitro susceptibility testing of BMS-284756 by the BSAC standardized disc testing method

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Minimum inhibitory concentration determinations for various antimicrobial agents against 1570 bacterial isolates from turkey poults.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Tests for bactericidal effects of antimicrobial agents: technical performance and clinical relevance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Susceptibility of Bacillus anthracis, Bacillus cereus, Bacillus mycoides, Bacillus pseudomycoides and Bacillus thuringiensis to 24 antimicrobials using Sensititre automated microbroth dilution and Etest agar gradient diffusion methods

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Comparative pharmacodynamics of gentamicin against Staphylococcus aureus and Pseudomonas aeruginosa

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Antimicrobial drug resistance in Escherichia coli from humans and food animals, United States, 1950-2002.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

LIVE/DEAD BacLight : application of a new rapid staining method for direct enumeration of viable and total bacteria in drinking water

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Analysis of cell cycle and replication of mouse macrophages after in vivo and in vitro Cryptococcus neoformans infection using laser scanning cytometry

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Old and New Glycopeptide Antibiotics: Action and Resistance

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

The Search for 'Evolution-Proof' Antibiotics

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Transcriptional regulators: valuable targets for novel antibacterial strategies

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Drugging tRNA aminoacylation.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

The importance of being modified: an unrealized code to RNA structure and function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

A Bright Future for Antibiotics?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Potential and use of bacterial small RNAs to combat drug resistance: a systematic review.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Emerging applications of riboswitches - from antibacterial targets to molecular tools

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Identification of neomycin B-binding site in T box antiterminator model RNA

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Structure-activity studies of RNA-binding oxazolidinone derivatives

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Synthesis and stereospecificity of 4,5-disubstituted oxazolidinone ligands binding to T-box riboswitch RNA.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Anisotropy studies of tRNA-T box antiterminator RNA complex in the presence of 1,4-disubstituted 1,2,3-triazoles.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Ligand-induced changes in T box antiterminator RNA stability.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Interfacing medicinal chemistry with structural bioinformatics: implications for T box riboswitch RNA drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Codon-Anticodon Recognition in the Bacillus subtilis glyQS T Box Riboswitch: RNA-DEPENDENT CODON SELECTION OUTSIDE THE RIBOSOME.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Direct modulation of T-box riboswitch-controlled transcription by protein synthesis inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Sequence-based design of bioactive small molecules that target precursor microRNAs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Bacterial Transcription Inhibitor of RNA Polymerase Holoenzyme Formation by Structure-Based Drug Design: From in Silico Screening to Validation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Synthesis and biological activity of novel mono-indole and mono-benzofuran inhibitors of bacterial transcription initiation complex formation.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Principles of early drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Physicochemical properties of antibacterial compounds: implications for drug discovery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Drugging the RNA World

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Cationic Branched Polyethylenimine (BPEI) Disables Antibiotic Resistance in Methicillin-Resistant Staphylococcus epidermidis (MRSE)

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Microbiology of secondary infections in Buruli ulcer lesions; implications for therapeutic interventions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Method of reliable determination of minimal lethal antibiotic concentrations

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Determination of minimum bactericidal concentrations of oxacillin for Staphylococcus aureus: influence and significance of technical factors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Resistance studies with daptomycin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Methods for determining spontaneous mutation rates

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Determining mutation rates in bacterial populations

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

On fluctuation analysis: a new, simple and efficient method for computing the expected number of mutants

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Fluctuation analysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Inhibitory effects of archetypical nucleic acid ligands on the interactions of HIV-1 nucleocapsid protein with elements of Psi-RNA.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Analyzing real-time PCR data by the comparative C(T) method

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201800744

7 January 2021

Identifiers

DOI

10.1002/CMDC.201800744

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30707489%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

1 reference