ATP2B4

ATP2B4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1CFF, 2KNE
Dynodwyr
Cyfenwau	ATP2B4, ATP2B2, MXRA1, PMCA4, PMCA4b, PMCA4x, ATPase plasma membrane Ca2+ transporting 4
Dynodwyr allanol	OMIM: 108732 HomoloGene: 48034 GeneCards: ATP2B4
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • PDZ domain binding; • sodium channel regulator activity; • nitric-oxide synthase binding; • scaffold protein binding; • metal ion binding; • calmodulin binding; • nitric-oxide synthase inhibitor activity; • GO:0001948, GO:0016582 protein binding; • protein phosphatase 2B binding; • ATP binding; • hydrolase activity; • P-type calcium transporter activity; • protein kinase binding;
Cydrannau o'r gell	• integral component of membrane; • cell projection; • bilen; • intracellular membrane-bounded organelle; • T-tubule; • Cellbilen; • integral component of plasma membrane; • sperm flagellum; • sperm principal piece; • basolateral plasma membrane; • Z discdkac; • caveola; • neuron projection; • sarcolemma; • cilium; • motile cilium; • GO:0009327 protein-containing complex; • glutamatergic synapse; • integral component of presynaptic active zone membrane;
Prosesau biolegol	• negative regulation of nitric oxide mediated signal transduction; • flagellated sperm motility; • regulation of cardiac conduction; • negative regulation of nitric-oxide synthase activity; • negative regulation of calcineurin-NFAT signaling cascade; • negative regulation of citrulline biosynthetic process; • negative regulation of peptidyl-cysteine S-nitrosylation; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • calcium ion import across plasma membrane; • response to hydrostatic pressure; • cellular calcium ion homeostasis; • cludo ïon; • positive regulation of peptidyl-serine phosphorylation; • cellular response to epinephrine stimulus; • cludo transmembrane rhwng ïonau; • negative regulation of nitric oxide biosynthetic process; • calcium ion transmembrane transport; • GO:0060401 calcium ion transmembrane import into cytosol; • spermatogenesis; • positive regulation of cAMP-dependent protein kinase activity; • regulation of cell cycle G1/S phase transition; • regulation of sodium ion transmembrane transport; • calcium ion export; • hippocampus development; • GO:0100045 negative regulation of arginine catabolic process; • neural retina development; • negative regulation of the force of heart contraction; • calcium ion transport; • negative regulation of cardiac muscle hypertrophy in response to stress; • GO:0015915 transport; • regulation of cytosolic calcium ion concentration; • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; • urinary bladder smooth muscle contraction; • cellular response to acetylcholine;
	Sources:Amigo / QuickGO
Orthologau
	493
	n/a
	ENSG00000058668
	n/a
	P23634
	n/a
	NM_001684; NM_001001396; NM_001365783; NM_001365784
	n/a
	NP_001001396; NP_001675; NP_001352712; NP_001352713
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ATP2B4 yw ATP2B4 a elwir hefyd yn ATPase plasma membrane Ca2+ transporting 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q32.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ATP2B4.

MXRA1
PMCA4
ATP2B2
PMCA4b
PMCA4x

Llyfryddiaeth

"Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data. ". PLoS Genet. 2015. PMID 26448358.
"PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion. ". Brain Behav. 2015. PMID 25798335.
"Substrate trajectory through phospholipid-transporting P4-ATPases. ". Biochem Soc Trans. 2014. PMID 25233416.
"PMCA4 (ATP2B4) mutation in familial spastic paraplegia. ". PLoS One. 2014. PMID 25119969.
"A C-terminal di-leucine motif controls plasma membrane expression of PMCA4b.". Biochim Biophys Acta. 2013. PMID 23830917.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ATP2B4 - Cronfa NCBI

[1]

[2]