Adenovirus-5 E1A: paradox and paradigm (Q34131278)

31 July 2017

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title

Adenovirus-5 E1A: paradox and paradigm (English)

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31 July 2017

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Steven M Frisch

1

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31 July 2017

Joe S Mymryk

series ordinal

2

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31 July 2017

publication date

1 June 2002

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Nature Reviews Molecular Cell Biology

31 July 2017

published in

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31 July 2017

volume

3

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31 July 2017

issue

6

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31 July 2017

page(s)

441-452

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Adenovirus E1A protein paradigm viral transactivator

31 July 2017

cites work

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Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA.

31 March 2020

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Size and location of the transforming region in human adenovirus type 5 DNA

31 March 2020

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Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

31 March 2020

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Adenovirus E1A: remodelling the host cell, a life or death experience

31 March 2020

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Characteristics of a human cell line transformed by DNA from human adenovirus type 5

31 March 2020

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Antioncogenic effect of adenovirus E1A in human tumor cells

31 March 2020

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Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene

31 March 2020

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The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins

31 March 2020

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Induction of apoptosis in fibroblasts by c-myc protein

31 March 2020

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Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo.

31 March 2020

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Transformation-defective adenovirus 5 E1A mutants exhibit antioncogenic properties in human BLM melanoma cells

31 March 2020

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Development of clinical trial of E1A gene therapy targeting HER-2/neu-overexpressing breast and ovarian cancer

31 March 2020

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The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

31 March 2020

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E-cadherin downregulation in cancer: fuel on the fire?

31 March 2020

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Carcinogenesis: A balance between β-catenin and APC

31 March 2020

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E1a induces the expression of epithelial characteristics

31 March 2020

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Evidence for a function of CtBP in epithelial gene regulation and anoikis

31 March 2020

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Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP.

31 March 2020

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Analysis of DNA binding by the adenovirus type 5 E1A oncoprotein

31 March 2020

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Functional interaction of adenovirus E1A with holo-TFIID

31 March 2020

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TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein

31 March 2020

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The zinc finger region of the adenovirus E1A transactivating domain complexes with the TATA box binding protein

31 March 2020

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Transcription factor TFIID is a direct functional target of the adenovirus E1A transcription-repression domain.

31 March 2020

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Subregions of the adenovirus E1A transactivation domain target multiple components of the TFIID complex

31 March 2020

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Transcriptional activation by the adenovirus larger E1a product is mediated by members of the cellular transcription factor ATF family which can directly associate with E1a

31 March 2020

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Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains.

31 March 2020

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Adenovirus E1A functions as a cofactor for retinoic acid receptor beta (RAR beta) through direct interaction with RAR beta

31 March 2020

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Regulation of the 26S proteasome by adenovirus E1A

31 March 2020

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RACK1 Interacts with E1A and Rescues E1A-induced Yeast Growth Inhibition and Mammalian Cell Apoptosis

31 March 2020

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Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A

31 March 2020

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A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity

31 March 2020

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Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A.

31 March 2020

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A novel Rb- and p300-binding protein inhibits transactivation by MyoD

31 March 2020

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A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

31 March 2020

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E1A directly binds and regulates the P/CAF acetyltransferase

31 March 2020

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

31 March 2020

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DNA damage activates p53 through a phosphorylation-acetylation cascade

31 March 2020

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Differential roles of p300 and PCAF acetyltransferases in muscle differentiation

31 March 2020

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Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program

31 March 2020

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Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5

31 March 2020

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Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis

31 March 2020

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E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products

31 March 2020

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Interactions between cell growth-regulating domains in the products of the adenovirus E1A oncogene

31 March 2020

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Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

31 March 2020

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The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.

31 March 2020

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TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

31 March 2020

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Antisense-mediated depletion of p300 in human cells leads to premature G1 exit and up-regulation of c-MYC.

31 March 2020

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Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling.

31 March 2020

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CBP/p300 histone acetyl-transferase activity is important for the G1/S transition

31 March 2020

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Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300

31 March 2020

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Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells

31 March 2020

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Mutations truncating the EP300 acetylase in human cancers

31 March 2020

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Suppression of tumor growth through disruption of hypoxia-inducible transcription

31 March 2020

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The epithelial cell default-phenotype hypothesis and its implications for cancer

31 March 2020

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The CtBP family: enigmatic and enzymatic transcriptional co-repressors

31 March 2020

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CtBP, an unconventional transcriptional corepressor in development and oncogenesis

31 March 2020

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Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation

31 March 2020

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A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor

31 March 2020

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Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

31 March 2020

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31 March 2020

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Disruption of epithelial cell-matrix interactions induces apoptosis

31 March 2020

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Indication of hypoxic areas in tumours from in vivo NADH fluorescence

31 March 2020

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Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides.

31 March 2020

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Effects of Ad5 E1A mutant viruses on the cell cycle in relation to the binding of cellular proteins including the retinoblastoma protein and cyclin A

31 March 2020

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The p400 complex is an essential E1A transformation target

31 March 2020

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Recruitment of TRRAP required for oncogenic transformation by E1A.

31 March 2020

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The Swi/Snf family nucleosome-remodeling complexes and transcriptional control

31 March 2020

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Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

31 March 2020

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The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

31 March 2020

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The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

31 March 2020

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Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression

31 March 2020

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Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

31 March 2020

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Sibling rivalry in the E2F family

31 March 2020

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31 March 2020

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p107 and p130: versatile proteins with interesting pockets

31 March 2020

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Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

31 March 2020

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Identification of distinct roles for separate E1A domains in disruption of E2F complexes

31 March 2020

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

31 March 2020

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The retinoblastoma gene: a prototypic and multifunctional tumor suppressor

31 March 2020

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Rb targets histone H3 methylation and HP1 to promoters

31 March 2020

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Cyclin A is a functional target of retinoblastoma tumor suppressor protein-mediated cell cycle arrest

31 March 2020

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Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins

31 March 2020

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Role of the LXCXE binding site in Rb function

31 March 2020

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Establishment of irreversible growth arrest in myogenic differentiation requires the RB LXCXE-binding function

31 March 2020

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RB regulates the stability and the apoptotic function of p53 via MDM2

31 March 2020

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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

31 March 2020

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Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins

31 March 2020

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Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase

31 March 2020

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Suppression of a yeast cyclic AMP-dependent protein kinase defect by overexpression of SOK1, a yeast gene exhibiting sequence similarity to a developmentally regulated mouse gene

31 March 2020

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minibrain: a new protein kinase family involved in postembryonic neurogenesis in Drosophila

31 March 2020

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Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases

31 March 2020

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Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells.

31 March 2020

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Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII

31 March 2020

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Localisation of a human homologue of the Drosophila mnb and rat Dyrk genes to chromosome 21q22.2

31 March 2020

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Interaction of the E1A oncoprotein with Yak1p, a novel regulator of yeast pseudohyphal differentiation, and related mammalian kinases

31 March 2020

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Differentially expressed genes identified in human melanoma cell lines with different metastatic behaviour using high density oligonucleotide arrays

31 March 2020

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Identification of genes involved in epithelial-mesenchymal transition and tumor progression

31 March 2020

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Adenovirus E1A proteins inhibit activation of transcription by p53.

31 March 2020

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Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.

31 March 2020

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Recruitment of p300/CBP in p53-dependent signal pathways

31 March 2020

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Binding and modulation of p53 by p300/CBP coactivators

31 March 2020

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The adenoviral E1A oncoproteins interfere with the growth-inhibiting effect of the cdk-inhibitor p21(CIP1/WAF1).

31 March 2020

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E1A can provoke G1 exit that is refractory to p21 and independent of activating cdk2

31 March 2020

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Deregulation of p53/p21Cip1/Waf1 pathway contributes to polyploidy and apoptosis of E1A+cHa-ras transformed cells after gamma-irradiation

31 March 2020

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Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells

31 March 2020

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p21 and retinoblastoma protein control the absence of DNA replication in terminally differentiated muscle cells

31 March 2020

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Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFbeta-treated cells

31 March 2020

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Interaction of p27 with E1A and its effect on CDK kinase activity

31 March 2020

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A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1).

31 March 2020

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Transformation of rat cells by DNA of human adenovirus 5

31 March 2020

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Cellular targets for transformation by the adenovirus E1A proteins

31 March 2020

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Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor

31 March 2020

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Intracellular localization of adenovirus type 5 tumor antigens in productively infected cells

31 March 2020

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7 January 2021

Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes

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7 January 2021

Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth

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7 January 2021

Inhibition of p53-mediated transactivation and cell cycle arrest by E1A through its p300/CBP-interacting region

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7 January 2021

The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.

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7 January 2021

Acetylation control of the retinoblastoma tumour-suppressor protein

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7 January 2021

Identifiers

DOI

10.1038/NRM827

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Dimensions Publication ID

31 July 2017

1040445267

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