Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair (Q24297983)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

0 references

Sung-Hwan Moon

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Lin Lin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Yolanda Darlington

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Alan S Waldman

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Xiongbin Lu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Lawrence A Donehower

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

English

0 references

publication date

29 January 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

17 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

17

1 reference

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17 January 2020

page(s)

12935-12947

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

17 January 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2857113/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Common mechanisms of PIKK regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication

19 March 2017

1 reference

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The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

19 March 2017

1 reference

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MDC1 is a mediator of the mammalian DNA damage checkpoint

19 March 2017

1 reference

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Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

19 March 2017

1 reference

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p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

19 March 2017

1 reference

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

19 March 2017

1 reference

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Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

19 March 2017

1 reference

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PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Substrate specificity of the human protein phosphatase 2Cdelta, Wip1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Chromosomal stability and the DNA double-stranded break connection

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Substrate specificities and identification of putative substrates of ATM kinase family members

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Modulation of error-prone double-strand break repair in mammalian chromosomes by DNA mismatch repair protein Mlh1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Genomic instability in mice lacking histone H2AX

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

ATR: an essential regulator of genome integrity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

7 April 2017

1 reference

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

7 April 2017

1 reference

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Cell cycle checkpoint signaling through the ATM and ATR kinases

7 April 2017

1 reference

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53BP1: function and mechanisms of focal recruitment

7 April 2017

1 reference

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Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

27 September 2017

1 reference

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An oncogene-induced DNA damage model for cancer development

27 September 2017

1 reference

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The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

27 September 2017

1 reference

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Accurate homologous recombination is a prominent double-strand break repair pathway in mammalian chromosomes and is modulated by mismatch repair protein Msh2.

27 September 2017

1 reference

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A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

The life and death of DNA-PK.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Phosphatases join kinases in DNA-damage response pathways.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

Molecular reactions of protein phosphatases--insights from structure and chemistry

27 September 2017

1 reference

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DNA repair: spot(light)s on chromatin.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857113

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

27 September 2017

1 reference

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Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

27 September 2017

1 reference

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Molecular mechanisms of the protein serine/threonine phosphatases

27 September 2017

1 reference

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Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.

27 September 2017

1 reference

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The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071696

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071696

Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.071696

Analysis of the p53 gene in human uterine carcinoma cell lines

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20118229

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20118229

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.071696

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20118229%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

20118229

2 references