Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53 (Q24299024)

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30 December 2019

title

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53 (English)

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Ubiquitin conjugating enzyme E2 D1

30 December 2019

main subject

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Ubiquitin conjugating enzyme E2 E1

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TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase

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Ubiquitin conjugating enzyme E2 D2

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protein K48-linked ubiquitination

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protein ubiquitination

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7

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30 December 2019

author name string

Rajeev Rajendra

1

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30 December 2019

Diptee Malegaonkar

2

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30 December 2019

Pooja Pungaliya

3

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30 December 2019

Henderson Marshall

4

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30 December 2019

Zeshaan Rasheed

5

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30 December 2019

James Brownell

6

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30 December 2019

Stuart Lutzker

8

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30 December 2019

Ahamed Saleem

9

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30 December 2019

Eric H Rubin

10

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30 December 2019

language of work or name

English

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publication date

9 July 2004

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Journal of Biological Chemistry

30 December 2019

published in

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30 December 2019

volume

279

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30 December 2019

issue

35

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30 December 2019

page(s)

36440-36444

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Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein

30 December 2019

cites work

1 reference

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Identification of a novel gene encoding a p53-associated protein

21 January 2018

1 reference

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Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence

21 January 2018

1 reference

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The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor

21 January 2018

1 reference

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The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies

21 January 2018

1 reference

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

1 reference

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The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.

21 January 2018

1 reference

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Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein

21 January 2018

1 reference

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The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation

21 January 2018

1 reference

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Mapping of the p53 and mdm-2 Interaction Domains

21 January 2018

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

1 reference

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

21 January 2018

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Role for nucleolin/Nsr1 in the cellular localization of topoisomerase I.

21 January 2018

1 reference

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Herpes simplex virus type 1 immediate-early protein ICP0 and is isolated RING finger domain act as ubiquitin E3 ligases in vitro

21 January 2018

1 reference

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

21 January 2018

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Structure and function of ubiquitin conjugating enzyme E2-25K: the tail is a core-dependent activity element.

21 January 2018

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Control of biochemical reactions through supramolecular RING domain self-assembly

21 January 2018

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A proteomics approach to understanding protein ubiquitination

21 January 2018

1 reference

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Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.

21 January 2018

1 reference

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Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 January 2018

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Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

21 January 2018

1 reference

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Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches.

21 January 2018

1 reference

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Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression

21 January 2018

1 reference

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

1 reference

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

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Regulation of p53 stability by Mdm2

21 January 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

21 January 2018

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Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

21 January 2018

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The ubiquitin ligase COP1 is a critical negative regulator of p53

21 January 2018

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Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

21 January 2018

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PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

21 January 2018

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PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

21 January 2018

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PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

21 January 2018

1 reference

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An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.C400300200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15247280%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference