The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy (Q24316726)

GOA release 2020-03-11

author

Henry Houlden

10

0 references

Helene Plun-Favreau

16

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David E Nelson

David E Nelson

2

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Alvaro Sanchez-Martinez

Alvaro Sanchez-Martinez

3

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Selina Wray

Selina Wray

8

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Patrick A. Lewis

Patrick A Lewis

9

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Alexander J. Whitworth

Alexander J Whitworth

14

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Andrey Y. Abramov

Andrey Y Abramov

11

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Nicholas W. Wood

Nicholas W Wood

13

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John Anthony Hardy

12

John Hardy

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Victoria S Burchell

1

Victoria S Burchell

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author name string

Marta Delgado-Camprubi

4

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Rachael M Ivatt

5

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Joe H Pogson

6

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Suzanne J Randle

7

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Heike Laman

Guidelines for the use and interpretation of assays for monitoring autophagy

15

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language of work or name

English

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publication date

September 2013

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published in

Nature Neuroscience

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volume

16

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issue

9

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page(s)

1257-65

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cites work

1 reference

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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

19 March 2017

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

19 March 2017

1 reference

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

19 March 2017

1 reference

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

19 March 2017

1 reference

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Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor

19 March 2017

1 reference

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Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region

19 March 2017

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Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells

19 March 2017

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A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins

19 March 2017

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Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin

19 March 2017

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FBXO7 mutations cause autosomal recessive, early-onset parkinsonian-pyramidal syndrome

19 March 2017

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The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination

19 March 2017

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Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

19 March 2017

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F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

19 March 2017

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

19 March 2017

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

7 April 2017

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Computational method to predict mitochondrially imported proteins and their targeting sequences

7 April 2017

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Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

7 April 2017

1 reference

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Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

7 April 2017

1 reference

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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

7 April 2017

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Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

7 April 2017

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

7 April 2017

1 reference

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

7 April 2017

1 reference

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

7 April 2017

1 reference

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

A knowledge base for predicting protein localization sites in eukaryotic cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin

7 April 2017

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Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila

7 April 2017

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Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.

27 September 2017

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A conserved F box regulatory complex controls proteasome activity in Drosophila

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Mitophagy and Parkinson's disease: the PINK1-parkin link.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Early-onset L-dopa-responsive parkinsonism with pyramidal signs due to ATP13A2, PLA2G6, FBXO7 and spatacsin mutations

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

A novel F-box protein is required for caspase activation during cellular remodeling in Drosophila

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3827746

Predotar: A tool for rapidly screening proteomes for N-terminal targeting sequences

27 September 2017

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNN.3489

21 January 2018

Identifiers

DOI

10.1038/NN.3489

1 reference

Dimensions Publication ID

1031900501

0 references

1 reference

1 reference

PubMed publication ID

23933751

1 reference