TGF-β/Smad signaling in renal fibrosis (Q26851198)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

review article

1 reference

title

TGF-β/Smad signaling in renal fibrosis (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Patrick Ming-Kuen Tang

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Hui Y Lan

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

author name string

Jun Li

series ordinal

3

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

language of work or name

1 reference

19 March 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

published in

Frontiers in Physiology

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

volume

6

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

page(s)

82

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

Macrophages promote renal fibrosis through direct and indirect mechanisms

4 March 2020

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

7 April 2017

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

7 April 2017

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The miR-200 and miR-221/222 microRNA families: opposing effects on epithelial identity

7 April 2017

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

7 April 2017

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High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells

7 April 2017

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

7 April 2017

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Signal transduction by the TGF-beta superfamily

7 April 2017

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

7 April 2017

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Role of the TGF-β/BMP-7/Smad pathways in renal diseases

7 April 2017

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Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

7 April 2017

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Mechanism of activation of the TGF-beta receptor

7 April 2017

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Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3

7 April 2017

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Transforming growth factor-beta regulates tubular epithelial-myofibroblast transdifferentiation in vitro

7 April 2017

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Mechanisms of fibrosis: therapeutic translation for fibrotic disease

7 April 2017

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Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

7 April 2017

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Transcriptional control by the TGF-beta/Smad signaling system

7 April 2017

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

7 April 2017

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Curtailing endothelial TGF-β signaling is sufficient to reduce endothelial-mesenchymal transition and fibrosis in CKD

7 April 2017

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GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-Induced Smad3 Phosphorylation

28 September 2017

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Inflammatory processes in renal fibrosis.

28 September 2017

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Potential approaches to reverse or repair renal fibrosis

28 September 2017

1 reference

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MicroRNA-29b inhibits diabetic nephropathy in db/db mice

28 September 2017

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MicroRNA and nephropathy: emerging concepts

28 September 2017

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Transforming growth factor-β1-mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b.

28 September 2017

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Transforming growth factor-β and the progression of renal disease

28 September 2017

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Origin and function of myofibroblasts in kidney fibrosis

28 September 2017

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Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis

28 September 2017

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Transforming growth factor-β1 (TGF-β1)-stimulated fibroblast to myofibroblast differentiation is mediated by hyaluronan (HA)-facilitated epidermal growth factor receptor (EGFR) and CD44 co-localization in lipid rafts

28 September 2017

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Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice.

28 September 2017

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miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes.

28 September 2017

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Smad7 suppresses renal fibrosis via altering expression of TGF-β/Smad3-regulated microRNAs

28 September 2017

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Transforming growth factor β-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis.

28 September 2017

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TGF-β/Smad signaling in kidney disease.

28 September 2017

1 reference

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Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21

28 September 2017

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miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice.

28 September 2017

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MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways

28 September 2017

1 reference

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Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy

28 September 2017

1 reference

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MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis

28 September 2017

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Role of TGF-β in chronic kidney disease: an integration of tubular, glomerular and vascular effects

28 September 2017

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Smad3-mediated upregulation of miR-21 promotes renal fibrosis

28 September 2017

1 reference

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TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29

28 September 2017

1 reference

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Diabetes complications: the microRNA perspective.

28 September 2017

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TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

28 September 2017

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Pirfenidone for diabetic nephropathy

28 September 2017

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A microRNA circuit mediates transforming growth factor-β1 autoregulation in renal glomerular mesangial cells

28 September 2017

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A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis

28 September 2017

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28 September 2017

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miR-200b precursor can ameliorate renal tubulointerstitial fibrosis

28 September 2017

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28 September 2017

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miR-200a Prevents renal fibrogenesis through repression of TGF-β2 expression

28 September 2017

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Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy

28 September 2017

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Identification of a microRNA signature of renal ischemia reperfusion injury

28 September 2017

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Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis.

28 September 2017

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Essential role for Smad3 in angiotensin II-induced tubular epithelial-mesenchymal transition.

28 September 2017

1 reference

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miR-192 mediates TGF-beta/Smad3-driven renal fibrosis

28 September 2017

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E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta

28 September 2017

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Renal medullary microRNAs in Dahl salt-sensitive rats: miR-29b regulates several collagens and related genes

28 September 2017

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Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression.

28 September 2017

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Mechanism of chronic aristolochic acid nephropathy: role of Smad3.

28 September 2017

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Loss of MicroRNA-192 promotes fibrogenesis in diabetic nephropathy

28 September 2017

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New insights into epithelial-mesenchymal transition in kidney fibrosis

28 September 2017

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Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling

28 September 2017

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Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis

28 September 2017

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Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition

28 September 2017

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Mice overexpressing latent TGF-beta1 are protected against renal fibrosis in obstructive kidney disease

28 September 2017

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Latent TGF-beta1 protects against crescentic glomerulonephritis

28 September 2017

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Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition

28 September 2017

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Fibrocytes: a new insight into kidney fibrosis

28 September 2017

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MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.

28 September 2017

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IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy

28 September 2017

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Accurate measurement and clinical significance of urinary transforming growth factor-beta1.

28 September 2017

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Essential role of Smad3 in angiotensin II-induced vascular fibrosis

28 September 2017

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The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFbeta1 responses in human proximal-tubule epithelial cells.

28 September 2017

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The endogenous ratio of Smad2 and Smad3 influences the cytostatic function of Smad3.

28 September 2017

1 reference

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Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney.

28 September 2017

1 reference

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Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

28 September 2017

1 reference

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Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

28 September 2017

1 reference

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Hierarchical model of gene regulation by transforming growth factor beta

28 September 2017

1 reference

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Role of TGF-beta signaling in extracellular matrix production under high glucose conditions.

28 September 2017

1 reference

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Role of Smad4 on TGF-beta-induced extracellular matrix stimulation in mesangial cells

28 September 2017

1 reference

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TGF-beta1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins

28 September 2017

1 reference

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TGF-beta signaling in renal disease

28 September 2017

1 reference

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Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways

28 September 2017

1 reference

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SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.

28 September 2017

1 reference

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Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4365692

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4365692

Fibrosis: the source of myofibroblasts in kidney fibrosis

28 September 2017

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Chronic kidney disease progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Smad7 gene therapy ameliorates an autoimmune crescentic glomerulonephritis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Smad3 mediates ANG II-induced hypertensive kidney disease in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Pentoxifylline inhibits transforming growth factor-beta signaling and renal fibrosis in experimental crescentic glomerulonephritis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Inhibition of TGF-β1-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts involves Smad3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Pirfenidone Slows Renal Function Decline in Patients with Focal Segmental Glomerulosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Renal Bone Morphogenetic Protein-7 Protects against Diabetic Nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Renal Fibrosis and Glomerulosclerosis in a New Mouse Model of Diabetic Nephropathy and Its Regression by Bone Morphogenic Protein-7 and Advanced Glycation End Product Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3389%2FFPHYS.2015.00082

Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4365692

Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension

28 November 2018

1 reference

12 December 2020

The miR-200 family regulates TGF-β1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression

1 reference

12 December 2020

Downregulation of Smad transcriptional corepressors SnoN and Ski in the fibrotic kidney: an amplification mechanism for TGF-beta1 signaling

1 reference

12 December 2020

Expression of transforming growth factor-beta isoforms in human glomerular diseases

1 reference

12 December 2020

Evidence that TGF-beta should be a therapeutic target in diabetic nephropathy

1 reference

12 December 2020

Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease

1 reference

12 December 2020

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

1 reference

12 December 2020

Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease

1 reference

12 December 2020

Urinary transforming growth factor-beta in patients with glomerular diseases

1 reference

12 December 2020

Effect of miR-21 on renal fibrosis by regulating MMP-9 and TIMP1 in kk-ay diabetic nephropathy mice

1 reference

12 December 2020

Identifiers

DOI

10.3389/FPHYS.2015.00082

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

PubMed publication ID

25852569

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25852569%20AND%20SRC:MED&resulttype=core&format=json