Divorcing ARF and p53: an unsettled case (Q28258356)

Tumor suppression by Ink4a-Arf: progress and puzzles

Europe PubMed Central

title

Divorcing ARF and p53: an unsettled case (English)

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author name string

Charles J Sherr

series ordinal

1

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language of work or name

English

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publication date

September 2006

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published in

Nature Reviews Cancer

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volume

6

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issue

9

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page(s)

663-73

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cites work

1 reference

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

Absence of p16INK4a and truncation of ARF tumor suppressors in chickens.

21 January 2018

1 reference

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

1 reference

Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

21 January 2018

1 reference

p53-independent functions of the p19(ARF) tumor suppressor

21 January 2018

1 reference

The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development

21 January 2018

1 reference

Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye.

21 January 2018

1 reference

Human ARF binds E2F1 and inhibits its transcriptional activity.

21 January 2018

1 reference

p53-independent apoptosis is induced by the p19ARF tumor suppressor

21 January 2018

1 reference

Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis

21 January 2018

1 reference

p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice

21 January 2018

1 reference

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

21 January 2018

1 reference

P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.

21 January 2018

1 reference

MDM2-ARF complex regulates p53 sumoylation

21 January 2018

1 reference

p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase

21 January 2018

1 reference

Localization of phosphorylated forms of Bcl-2 in mitosis: co-localization with Ki-67 and nucleolin in nuclear structures and on mitotic chromosomes.

21 January 2018

1 reference

Sumoylation induced by the Arf tumor suppressor: a p53-independent function

21 January 2018

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Protein modification by SUMO

21 January 2018

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SUMO--nonclassical ubiquitin

21 January 2018

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Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

21 January 2018

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Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

21 January 2018

1 reference

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

21 January 2018

1 reference

Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

21 January 2018

1 reference

Major nucleolar proteins shuttle between nucleus and cytoplasm

21 January 2018

1 reference

21 January 2018

Nucleophosmin and cancer

1 reference

Nucleolar protein B23 has molecular chaperone activities

21 January 2018

1 reference

Role of nucleophosmin in embryonic development and tumorigenesis

21 January 2018

1 reference

Nucleophosmin is required for DNA integrity and p19Arf protein stability

21 January 2018

1 reference

Stability of nucleolar versus non-nucleolar forms of human p14(ARF).

21 January 2018

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N-terminal polyubiquitination and degradation of the Arf tumor suppressor

21 January 2018

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Protein degradation and protection against misfolded or damaged proteins

21 January 2018

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Human Arf tumor suppressor specifically interacts with chromatin containing the promoter of rRNA genes.

21 January 2018

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Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing

21 January 2018

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Nucleophosmin is essential for ribosomal protein L5 nuclear export

21 January 2018

1 reference

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

21 January 2018

1 reference

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

21 January 2018

1 reference

p53 represses ribosomal gene transcription

21 January 2018

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Repression of RNA polymerase I transcription by the tumor suppressor p53

21 January 2018

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Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

21 January 2018

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Regulation of p14ARF through subnuclear compartmentalization

21 January 2018

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Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

1 reference

Identification of a cryptic nucleolar-localization signal in MDM2

21 January 2018

1 reference

E2F target genes: unraveling the biology

21 January 2018

1 reference

Hitting their targets: an emerging picture of E2F and cell cycle control

21 January 2018

1 reference

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

21 January 2018

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Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

21 January 2018

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Distinct E2F-mediated transcriptional program regulates p14ARF gene expression

21 January 2018

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p19ARF targets certain E2F species for degradation.

21 January 2018

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Differential regulation of E2F1, DP1, and the E2F1/DP1 complex by ARF.

21 January 2018

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ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.

21 January 2018

1 reference

p19ARF directly and differentially controls the functions of c-Myc independently of p53.

21 January 2018

1 reference

Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.

21 January 2018

1 reference

Histone sumoylation is associated with transcriptional repression

21 January 2018

1 reference

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

21 January 2018

1 reference

The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

21 January 2018

1 reference

MYC recruits the TIP60 histone acetyltransferase complex to chromatin

21 January 2018

1 reference

p14ARF directly interacts with Myc through the Myc BoxII domain

21 January 2018

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p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress

21 January 2018

1 reference

p14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation

21 January 2018

1 reference

Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor

21 January 2018

1 reference

New and unexpected: forkhead meets ARF.

21 January 2018

1 reference

The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression

21 January 2018

1 reference

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

ATM activity contributes to the tumor-suppressing functions of p14ARF.

21 January 2018

1 reference

p14ARF is a component of the p53 response following ionizing irradiation of normal human fibroblasts

21 January 2018

1 reference

ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress.

21 January 2018

1 reference

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

1 reference

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

21 January 2018

1 reference

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

21 January 2018

1 reference

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

21 January 2018

1 reference

Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer

21 January 2018

1 reference

Efficient IgG-mediated suppression of primary antibody responses in Fcgamma receptor-deficient mice.

21 January 2018

1 reference

Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor

21 January 2018

1 reference

ARF the integrator: linking NF-kappaB, p53 and checkpoint kinases

21 January 2018

1 reference

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

21 January 2018

1 reference

DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF.

21 January 2018

1 reference

A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death

21 January 2018

1 reference

The role of autophagy in cancer development and response to therapy.

21 January 2018

1 reference

Autophagy in metazoans: cell survival in the land of plenty

21 January 2018

1 reference

What have animal models taught us about the p53 pathway?

21 January 2018

1 reference

Unleashing the power of p53: lessons from mice and men.

21 January 2018

1 reference

Oligomerization of the human ARF tumor suppressor and its response to oxidative stress

21 January 2018

1 reference

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

21 January 2018

1 reference

Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein

21 January 2018

1 reference

Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant

21 January 2018

1 reference

Identification of novel ARF binding proteins by two-hybrid screening

21 January 2018

1 reference

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

21 January 2018

1 reference

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling

21 January 2018

1 reference

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53

21 January 2018

1 reference

A novel putative collaborator of p19ARF

21 January 2018

1 reference

Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control

21 January 2018

1 reference

Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis

21 January 2018

1 reference

The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription

21 January 2018

1 reference

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

21 January 2018

1 reference

Inhibition of p63 transcriptional activity by p14ARF: functional and physical link between human ARF tumor suppressor and a member of the p53 family

21 January 2018

1 reference

Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition

21 January 2018

1 reference

Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway

21 January 2018

1 reference

The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein

21 January 2018

1 reference

Functional and physical interaction of the human ARF tumor suppressor with Tat-binding protein-1.

21 January 2018

1 reference

Human ARF protein interacts with topoisomerase I and stimulates its activity

21 January 2018

1 reference

Yin Yang 1 is a negative regulator of p53.

21 January 2018

1 reference

p53- and Mdm2-Independent Repression of NF-κB Transactivation by the ARF Tumor Suppressor

21 January 2018

1 reference

p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways

21 January 2018

1 reference

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

31 March 2020

1 reference

Mapping the functional domains of nucleolar protein B23

31 March 2020

1 reference

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

31 March 2020

1 reference

Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis

31 March 2020

1 reference

Antagonism of Myc functions by Arf

31 March 2020

1 reference

P19ARF inhibits the functions of the HPV16 E7 oncoprotein

31 March 2020

1 reference